Journal of Radiation Research and Applied Sciences,
Год журнала:
2024,
Номер
17(3), С. 101043 - 101043
Опубликована: Июль 29, 2024
Amide
proton
transfer
(APT)
magnetic
resonance
imaging
(MR)
is
a
new
technology
that
has
shown
promise
in
the
non-invasive
characterization
of
brain
malignancies,
particularly
meningiomas
and
glioblastomas.
Th
works
aims
to
evaluate
existing
literature
explore
efficacy
APT
MR
glioblastomas
tumors.
The
review
gives
an
overview
principles,
examines
its
potential
benefits
limits,
highlights
important
findings
from
selected
research.
To
discover
relevant
research
published
up
current
day,
search
was
undertaken
electronic
databases
such
as
PubMed
Google
Scholar.
based
on
keywords
medical
terms
related
imaging,
meningiomas,
It
showed
majority
studies
found
encouraging
results
distinguishing
surrounding
normal
tissue
using
imaging.
For
tumor
characterization,
signal
intensity
assessments
asymmetry
analysis
ratio
were
used.
work
concluded
be
method
for
diagnosis
provides
useful
information
about
metabolism
cellular
composition,
which
can
help
with
diagnosis,
therapy
planning,
prognosis.
Theranostics,
Год журнала:
2024,
Номер
14(10), С. 4127 - 4146
Опубликована: Янв. 1, 2024
Biomarker-driven
molecular
imaging
has
emerged
as
an
integral
part
of
cancer
precision
radiotherapy.
The
use
probes,
including
nanoprobes,
have
been
explored
in
radiotherapy
to
precisely
and
noninvasively
monitor
spatiotemporal
distribution
biomarkers,
potentially
revealing
tumor-killing
mechanisms
therapy-induced
adverse
effects
during
radiation
treatment.
Biomacromolecules,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 11, 2024
Glioblastoma
multiforme
(GBM)
is
a
highly
malignant
brain
tumor
with
poor
prognosis
and
limited
treatment
options.
Drug
delivery
by
stimuli-responsive
nanocarriers
holds
great
promise
for
improving
the
modalities
of
GBM.
At
beginning
review,
we
highlighted
stimuli-active
polymeric
carrying
therapies
that
potentially
boost
anti-GBM
responses
employing
endogenous
(pH,
redox,
hypoxia,
enzyme)
or
exogenous
stimuli
(light,
ultrasonic,
magnetic,
temperature,
radiation)
as
triggers
controlled
drug
release
mainly
via
hydrophobic/hydrophilic
transition,
degradability,
ionizability,
etc.
Modifying
these
target
ligands
further
enhanced
their
capacity
to
traverse
blood-brain
barrier
(BBB)
preferentially
accumulate
in
glioma
cells.
These
unique
features
lead
more
effective
cancer
minimal
adverse
reactions
superior
therapeutic
outcomes.
Finally,
review
summarizes
existing
difficulties
future
prospects
treating
Overall,
this
offers
theoretical
guidelines
developing
intelligent
versatile
facilitate
precise
GBM
clinical
settings.
Analytical Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 3, 2025
The
challenge
of
"false
positive"
signals
significantly
complicates
tumor
localization
and
surgical
resection,
which
are
pivotal
for
successful
surgeries.
Therefore,
the
development
a
method
preoperative
intraoperative
margin
determination
holds
considerable
promise
improving
outcomes.
In
this
study,
zero-crosstalk
ratiometric
tumor-targeting
near-infrared
(NIR)
fluorescent
probe
was
developed
precise
cancer
diagnosis
navigation
via
NIR
fluorescence
imaging.
This
integrates
moiety
that
selectively
homes
in
on
hepatocellular
carcinoma
cells
exhibits
highly
sensitive
response
to
γ-glutamyltranspeptidase
(GGT),
characterized
by
substantial
emission
shift
from
830
650
nm.
unique
property
enhances
its
effectiveness
early
imaging-guided
surgery
resection.
Furthermore,
successfully
monitors
GGT
activity
blood,
cells,
vivo,
endowing
potential
clinic.
Due
efficient
targeting
situ
both
subcutaneous
tumors
orthotopic
hepatic
tumors,
accurate
detection
capability
tumors.
Additionally,
leveraging
imaging,
can
serve
as
sprayable
tool
delineating
margins
with
precision,
thereby
furnishing
real-time
imaging
guidance
during
resection
surgery.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 24, 2025
Abstract
Glioblastoma
(GBM)
stands
as
the
most
aggressive
malignant
brain
tumor,
characterized
by
poor
prognosis,
high
recurrence
rate,
and
resistance
to
multiple
therapies,
posing
a
significant
clinical
challenge.
Here,
hierarchical
targeting
platform
is
presented
for
NIR‐II
photoacoustic
(PA)
imaging‐guided
photo‐chemo
synergistic
immunotherapy
of
GBM.
A
new
molecular
probe
developed
with
exceptional
light‐harvesting
capabilities
enhanced
motion,
boosting
both
photothermal
conversion
PA
signal.
This
probe,
combined
thermo‐responsive
prodrug,
assembled
into
nanoparticles
that
are
further
camouflaged
tumor
cell
membranes
bioorthogonally
modified
transferrin‐mimicking
peptide,
facilitating
blood‐brain
barrier
penetration
GBM
targeting.
High‐contrast
imaging
allows
precise
detection
delineation
GBM,
providing
accurate
guidance
subsequent
treatment.
The
light‐triggered
effect,
coupled
hyperthermia‐activated
significantly
induces
immunogenic
death,
enhancing
tumor‐killing
efficiency
amplifying
anti‐tumor
immune
response.
self‐synergistic
not
only
stimulates
robust
immunity
inhibits
primary
growth
but
also
prevents
post‐surgical
recurrence,
prolonging
survival
time.
work
exemplifies
novel
paradigm
tackling
diagnostic
therapeutic
challenges
posed
deeply
seated
poorly
tumors.
Advances in Wound Care,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 18, 2025
Significance:
Osteoarthritis
(OA),
one
of
the
most
prevalent
joint
diseases
affecting
more
than
240
million
people,
strongly
influences
human
health
and
reduces
life
quality.
This
review
aims
to
fill
current
research
gap
regarding
application
potential
mitochondrial
quality
control
(MQC)
based
therapies
in
treatment
OA,
thereby
providing
guidance
for
future
clinical
practice.
Recent
Advances:
Chondrocytes
respond
inflammatory
microenvironment
via
an
array
signaling
pathways
thus
are
critical
cartilage
degeneration
OA
progression.
Mitochondria,
as
important
metabolic
center
chondrocytes,
play
a
vital
role
responding
stimuli.
Multiple
MQC
mechanisms,
including
antioxidant
defense,
protein
control,
DNA
repair,
dynamics,
mitophagy,
biogenesis,
sustain
homeostasis
under
pathological
conditions.
Critical
Issues:
Despite
extensive
research,
effective
remain
limited.
Elucidating
mechanisms
disease
progression
post-traumatic
repair
is
crucial.
While
preclinical
studies
demonstrate
potential,
translation
requires
addressing
protocol
standardization,
patient
stratification,
long-term
efficacy,
well
safety
validation.
Future
Directions:
should
focus
on
developing
personalized
MQC-based
guided
by
biomarker
profiling
pathway
modulation.
However,
translational
challenges
persist,
particularly
pervasive
off-target
effects,
inadequate
OA-specific
targeting
capacity,
interpatient
heterogeneity,
reliable
evaluation
therapeutic
efficacy.
Strategic
prioritization
targets
coupled
with
delivery
system
optimization
may
significantly
improve
both
translatability
outcomes.
Advanced Materials,
Год журнала:
2024,
Номер
36(35)
Опубликована: Авг. 1, 2024
Bacterial-derived
micro-/nanomedicine
has
garnered
considerable
attention
in
anticancer
therapy,
owing
to
the
unique
natural
features
of
bacteria,
including
specific
targeting
ability,
immunogenic
benefits,
physicochemical
modifiability,
and
biotechnological
editability.
Besides,
bacterial
components
have
also
been
explored
as
promising
drug
delivery
vehicles.
Harnessing
these
features,
cutting-edge
biotechnologies
applied
attenuated
tumor-targeting
bacteria
with
properties
or
functions
for
potent
effective
cancer
treatment,
strategies
gene-editing
genetic
circuits.
Further,
advent
bacteria-inspired
micro-/nanorobots
mimicking
artificial
systems
furnished
fresh
perspectives
formulating
developing
highly
efficient
systems.
Focusing
on
advantages
this
review
delves
into
advances
bacteria-derived
treatment
recent
years,
which
experienced
a
process
from
living
entities
Meanwhile,
summary
relative
clinical
trials
is
provided
primary
challenges
impeding
their
application
are
discussed.
Furthermore,
future
directions
suggested
combat
cancer.
