Pt–PtTe₂ Nanoparticles with Heterojunction-Based Accelerated Electron Transfer for Efficient Tumor Therapy

ACS Applied Nano Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

Язык: Английский

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Interpretable Active Learning Identifies Iron‐Doped Carbon Dots With High Photothermal Conversion Efficiency for Antitumor Synergistic Therapy

Aggregate, Год журнала: 2025, Номер unknown

Опубликована: Май 21, 2025

ABSTRACT Active learning (AL) is a powerful method for accelerating novel materials discovery but faces huge challenges extracting physical meaning. Herein, we novelly apply an interpretable AL strategy to efficiently optimize the photothermal conversion efficiency (PCE) of carbon dots (CDs) in therapy (PTT). An equivalent value (SHapley Additive exPlanations [SHAP‐EV]) proposed which explicitly quantifies linear contributions experimental variables PCE, derived from joint SHAP values. The SHAP‐EV, with R 2 0.960 correlated feature's SHAP, integrated into utility functions enhance evaluation during optimization. Using this approach, successfully synthesized iron‐doped CDs (Fe‐CDs) PCE exceeding 78.7% after only 16 trials over four iterations. This achievement significantly advances previously low values typically reported CDs. Furthermore, Fe‐CDs demonstrated multienzyme‐like activities, could respond tumor microenvironment (TME). In vitro and vivo experiments demonstrate that ferroptosis through synergistic PTT chemodynamic (CDT), thereby achieving remarkable antitumor efficacy. Our offers new insights bio‐functional development treatments.

Язык: Английский

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Towards precision medicine: design considerations for nanozymes in tumor treatment

Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)

Опубликована: Ноя. 16, 2024

Since the discovery of Fe3O4 nanoparticles with enzyme-like activity in 2007, nanozymes have emerged as a promising class catalysts, offering advantages such high catalytic efficiency, low cost, mild reaction conditions, and excellent stability. These properties make highly suitable for large-scale production. In recent years, convergence nanomedicine nanocatalysis has highlighted potential diagnostic therapeutic applications, particularly tumor therapy. Despite these advancements, clinical translation remains hindered by lack designs tailored to specific characteristics, limiting their effectiveness targeted This review addresses mechanisms which induce cell death various types emphasizes key design considerations needed enhance potential. By identifying challenges opportunities field, this study aims provide foundation future nanozyme development, ultimately contributing more precise effective cancer treatments.

Язык: Английский

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Porous Fe/Cu Nanoreactor with Dual Insurance Design for Precision Chemotherapy and Chemodynamic Therapy

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

Abstract Poor prognosis and chemotherapy response stem from difficulties in precise targeting the lack of effective synergistic treatments. Nanozymes show promising potential tumor chemodynamic therapy (CDT) by catalyzing hydrogen peroxide (H₂O₂) decomposition glutathione depletion microenvironment (TME). However, integrating with CDT remains challenging. In this study, a porous Fe/Cu bimetallic nanozyme carrier (FeCuNPs) is developed for co‐loading humanized 3F8 anti‐GD2 disialoganglioside antibody (3F8) novel pyridazinone‐based chemotherapeutic agent (IMB), forming nanoreactor (3F8@FeCuNPs@IMB) targeted CDT. The responds specifically to acidic TME as primary insurance, allowing controlled release IMB at site. coating on surface acts secondary minimizing drug leakage during delivery process ensuring chemotherapy. Furthermore, FeCuNPs act peroxidase‐like (POD) oxidase‐like (GSHOX) enzymes, hydroxyl radical (•OH) generation depleting excess GSH, enhancing results vitro vivo indicate that dual insurance designed 3F8@FeCuNPs@IMB offers prospect targeted, precise, combination against melanoma.

Язык: Английский

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Bioinspired O₂‐Evolution Catalysts with Proton‐Coupled Electron Transfer Pathway for Portable Oxygen Generation

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 16, 2025

Abstract Producing high‐purity oxygen (O 2 ) has a wide range of applications across diverse sectors, such as medicine, tunnel construction, the chemical industry, and fermentation. However, current O production methods are burdened by complexity, heavy equipment, high energy consumption, limited adaptability to harsh environments. Here, address this grand challenge, de novo design Ru‐doped metal hydroxide is proposed serve bioinspired ‐evolution catalysts with proton‐coupled electron transfer (PCET) pathway for low‐energy, environmentally friendly, cost‐effective, portable generation. The comprehensive studies confirm that lattice H species in Ru‐Co(OH) x ‐based catalyst can trigger PCET optimize Ru‐oxygen intermediates interactions, thus ultimately reducing reaction barriers improving activities durabilities. Consequently, prepared ‐loaded membrane exhibit rapid long‐term stable capabilities. Furthermore, material strategy H‐species shows remarkable universality broad hydroxides. This efficient, portable, cost‐effective generation technique suggested ensure an uninterrupted supply during emergencies regions availability or air pollution, offering significant societal benefits applications.

Язык: Английский

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Biosynthesized Calcium Peroxide Nanoparticles as a Multifunctional Platform for Liver Cancer Therapy

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(10), С. 4696 - 4696

Опубликована: Май 14, 2025

To overcome the limitations associated with chemically synthesized nanoparticles in cancer therapy, researchers have increasingly focused on developing superior biocompatibility and prolonged tumor retention using biosynthetic methods. In this study, we first identified presence of calcium peroxide (CaO2 NPs) blood individuals who had ingested gluconate. Furthermore, dropwise addition gluconate to human serum resulted spontaneous self-assembly CaO2 NPs. Next, following tail vein injection fluorescently labeled NPs into subcutaneous tumor-bearing nude mice, observed that exhibited accumulation at sites compared other organs through visible-light imaging. Immunofluorescence staining demonstrated co-localized vesicular transport-associated proteins, such as PV-1 Caveolin-1, well albumin-binding-associated protein SPARC, suggesting their transport from vessels site is mediated by Caveolin-1- SPARC-dependent active pathways. Additionally, analysis various normal mice injected concentrations significantly higher than experimental dose showed no apparent organ damage. Hemolysis assays indicated hemolysis occurred only 300 µg/mL, whereas concentration remained below threshold detectable hemolytic activity. a mouse model, treatment docetaxel-loaded 68.5% reduction volume free docetaxel (DTX) alone. These novel excellent biocompatibility, site, safety, drug-loading capability.

Язык: Английский

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Bimetallic Plasmonic Nanozyme‐Based Microneedle for Synergistic Ferroptosis Therapy of Melanoma

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Май 19, 2025

Abstract Melanoma is the most common malignant skin tumor, characterized by complexity, invasiveness, and heterogeneity. Conventional therapies often yield poor outcomes, posing significant clinical challenges. Here, a microneedle (MN) patch that integrates nanozyme traditional Chinese medicine (TCM) for ferroptosis pathway‐dependent combined therapy of melanoma designed. To amplify therapeutic activity, novel Au@MoS 2 bimetallic plasmonic (BPNzyme) prepared through simple aqueous synthesis strategy involving two‐step process. Owing to synergy between heterostructures, this rationally designed BPNzyme exhibits significantly enhanced characteristics, including near‐infrared (NIR) photothermal effect, peroxidase‐like glutathione property, which can effectively reshape tumor microenvironment disrupt redox homeostasis. Under action TCM β‐elemene (β‐ELE) NIR light, further enhancement oxidative damage, lipid peroxidation, peroxidase 4 expression downregulation are observed cells, validating synergistic amplification ferroptosis. Moreover, transdermal delivery β‐ELE using soluble hyaluronic acid MN achieves 99.8% growth suppression without systemic toxicity in vivo. These findings highlight potential BPNzyme‐based system as promising innovative non‐invasive, efficient, safe combination melanoma.

Язык: Английский

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Synergistic Pt-Mo pair sites on molybdenum carbides for bionic and portable oxygen production

Materials Science and Engineering R Reports, Год журнала: 2025, Номер 165, С. 101026 - 101026

Опубликована: Июнь 2, 2025

Язык: Английский

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2D manganese-doped calcium carbonate nanosheets as activable MRI/US imaging Guided enhanced calcium influx for Boosted regulatory cell death

Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 158309 - 158309

Опубликована: Дек. 1, 2024

Язык: Английский

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A Precision Mo₄VC₄‐Based Nanomedicine for Effective Cancer Elimination by Harnessing Senescence Induction and Immunogenic Response

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 27, 2024

Abstract Interest in therapies that influence cell senescence to regulate cancer is increasing. However, the understanding of prolonged state senescent cells and interactions involved when utilizing promote alongside other techniques suppress progression limited. This study introduces an innovative artificial nanozyme named MVPR, constructed from vanadium MXene (Mo 4 VC ) combined with cyclin‐dependent kinase inhibitors Palbociclib Arg‐Gly‐Asp, for precise targeting membranes. Within tumor environment, MVPR initiates a cascade catalytic reactions, boosting glutathione consumption, generating reactive oxygen species (ROS). When damage ROS exceeds cellular repair capabilities, redox balance disrupted, resulting apoptosis. Alternatively, can be triggered under different circumstances. Senescent impede their own nearby growth by releasing cytokines, thereby effectively curtail uncontrolled proliferation. Furthermore, immune response recruitment evoked metal ions together enhance immunotherapeutic effect, system activity augmenting CD4 + /CD8 T Cancer are eliminated through actions pro‐senescence, enzyme catalysis, immunogenic response. proposes pro‐senescence strategy anti‐tumor therapy.

Язык: Английский

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