Small, Год журнала: 2024, Номер unknown

Опубликована: Окт. 29, 2024

Abstract Altered redox homeostasis has long been observed in cancer cells, which can be exploited for therapeutic benefits. However, reactive oxygen species (ROS) pleiotropy coupling with reductive adaptation cells poses a formidable challenge dyshomeostasis‐based therapy. Herein, AuPd alloying nanozyme‐glutathione (GSH) biosynthesis inhibitor co‐delivery system (B‐BMES) is developed using dendritic SiO 2 as matrix to target homeostasis. By optimizing element composition, the nanozyme B‐BMES exhibits potent peroxidase (POD)‐like activity trigger ROS insults‐mediated dyshomeostasis. Such POD functionality attributed optimized electronic structure and catalytic activity. Simultaneously, abrogates by exerting its molecule‐targeted GSH suppression, thereby achieving dual‐disruption on Camouflaging tumor‐homologous cytomembrane, hybrid nanosystem biological stability tumor‐targeting ability further fabricated, initiates safe, precise disruption‐based therapy sensibilizes standard chemotherapy.

Язык: Английский