bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Авг. 6, 2024
Radionuclides used for imaging and therapy can show high molecular specificity in the body with appropriate targeting ligands. We hypothesized that local energy delivered by molecularly targeted radionuclides could chemically activate prodrugs at disease sites while avoiding activation off-target of toxicity. As proof-of-principle, we tested whether this strategy "
Язык: Английский
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Фев. 6, 2025
Abstract Localized liquid secretion, being an important process in nature such as the secretion of tears or mucus, has been attractive point developing biomimetic materials. However, precise localization remains challenging due to cohesive and mobile liquids. In this paper, light‐induced localized is demonstrated on scale tens micrometers by a crystal polymer coating with alternating homeotropic‐planar alignment. The light responsiveness achieved incorporation azobenzene derivative. applying regional through‐thickness electric fields monomeric crystals before polymerization. polymerized preserves both homeotropic planar Upon actuation, can be locally secreted from region while suppressed area. This method allows control over various patterns based different pre‐designed electrodes, which paves way for development responsive devices multitude fields, targeted drug delivery, tissue engineering, microfluidic devices.
Язык: Английский
Процитировано
1
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Фев. 27, 2025
Benefiting from the unique properties of ionizing radiation, such as high tissue penetration, spatiotemporal resolution, and clinical relevance compared with other external stimuli, radiotherapy-induced drug release strategies are showing great promise in developing effective personalized cancer treatments. However, requirement doses X-ray irradiation to break chemical bonds for limits application prodrug activation clinics. Recent advances nanomaterials offer a promising approach radiotherapy sensitization well integrating multiple modalities improved therapy outcomes. In particular, catalytic radiosensitization that utilizes electrons energy generated by upon has demonstrated excellent potential enhanced radiotherapy. this Review, we summarize design principles X-ray-responsive controlled release, radiosensitization, recent progress nanoradiosensitizers integration chemotherapy, chemodynamic therapy, photodynamic photothermal gas immunotherapy. Finally, discuss challenges heading toward possible translation. We expect emerging based on radiotherapy-triggered will facilitate frontier accurate near future.
Язык: Английский
Процитировано
0
Molecular Cancer, Год журнала: 2025, Номер 24(1)
Опубликована: Март 6, 2025
Clinical cancer treatment modalities include radiation as one of the first-line therapies used for treating almost two-thirds patients. Combinational therapy is becoming extremely popular, with multiple and their pharmacological effects expected to provide a synergistic outcome. The nanotechnology-based combinational therapeutic approach emerging more effective strategy, its advantages simultaneous loading drugs, on-demand drug delivery controlled by external or internal stimulus, targeting particular site, potential combine physical (like radiation, thermal therapies, etc.) chemical interventions chemotherapy, immunotherapy, etc.). We report combination radiotherapy chemotherapy mediated multifunctional lipo-polymeric hybrid nanosystem coated gold, demonstrating three different functionalities using single nanosystem: a) radio sensitization, b) radiation-triggered c) application an X-ray/CT contrast agent. nanoparticles, synthesized modified hydrogel isolation method, were loaded natural plant-derived anti-cancer agent "Caflanone." These nanoparticles further subjected in-situ reduction surface coating which provided enhanced radiosensitivity, triggered imaging. This leverages biocompatibility system precise spatiotemporal controllability release, cytotoxicity A significant efficacy in vitro against breast (p = 0.0002), pancreatic < 0.0001), glioblastoma 0.0001) was demonstrated approach. has been shown vivo tumor-bearing mice safety profile histopathology evaluated healthy showed no adverse effects. increase 0.01) survival treated also demonstrated. engineered release at tumor triggering action encapsulated chemotherapeutic agents while providing image guidance.
Язык: Английский
Процитировано
0
Coordination Chemistry Reviews, Год журнала: 2025, Номер 535, С. 216630 - 216630
Опубликована: Март 30, 2025
Язык: Английский
Процитировано
0
Nanoenergy Advances, Год журнала: 2025, Номер 5(2), С. 4 - 4
Опубликована: Март 31, 2025
Nowadays, due to improvements in living standards, more attention is reserved all-around disease prevention and health care. In particular, research efforts have been made for developing novel methods treatments anti-cancer therapy. Self-powered nanogenerators emerged recent years as an attractive cost-effective technology harvest energy or biosensing applications. Bioelectronic can be used inducing tissue recovery treating human illness through electrical stimulation. However, there still a lack of comprehensive cognitive assessment these devices platforms, especially regarding which requirements must satisfied working principles transduction adopted effectively the body. This review covers most advances bioelectronic therapy, based on different transducing strategies (photodynamic drug delivery, stimulation, atomic nanogenerators, etc.), potential mechanisms repair promotion are discussed. The prospective challenges finally summarized with indication future outlook.
Язык: Английский
Процитировано
0
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Апрель 17, 2025
Abstract The efficacy of radiotherapy (RT) is often limited by insufficient tumor selectivity and suboptimal therapeutic responses. To overcome these problems, a new kind selenium‐doped Ag/Ag 2 S Janus nanoparticles (Ag/Ag Se x y JNPs) presented as radio‐responsive molecular probes for precise imaging enhanced radiosensitization. By adjusting the selenium precursor input, heterojunction with tunable doping ratios are synthesized, optimizing X‐ray absorption energy storage properties. Upon irradiation, JNPs interact overexpressed hydrogen peroxide (H O ) in cells, generating highly toxic hydroxyl radicals (·OH), which effectively induce cell apoptosis. Additionally, Selenium incorporation improves electron–hole pair separation efficiency enhances photocurrent response, promoting increased electron transfer ·OH generation, thus amplifying reactive oxygen species (ROS) production enhancing Furthermore, fluorescence “OFF‐ON” mechanism, triggered H ‐induced etching silver allows real‐time monitoring levels via second near‐infrared window (NIR‐II) (FL) “Turn On”, delineates boundaries RT reduce side effects to normal tissue. This dual‐functional platform not only enables tracking but also outcomes, offering promising approach precision cancer treatment.
Язык: Английский
Процитировано
0
Nature Reviews Materials, Год журнала: 2024, Номер 9(4), С. 228 - 228
Опубликована: Март 27, 2024
Язык: Английский
Процитировано
1
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Авг. 6, 2024
Radionuclides used for imaging and therapy can show high molecular specificity in the body with appropriate targeting ligands. We hypothesized that local energy delivered by molecularly targeted radionuclides could chemically activate prodrugs at disease sites while avoiding activation off-target of toxicity. As proof-of-principle, we tested whether this strategy "
Язык: Английский
Процитировано
0