Calcium‐Dependent Signaling in Astrocytes: Downstream Mechanisms and Implications for Cognition

Journal of Neurochemistry, Год журнала: 2025, Номер 169(2)

Опубликована: Фев. 1, 2025

Astrocytes are glial cells recognized for their diverse roles in regulating brain circuit structure and function. They can sense adapt to changes the microenvironment due unique structural biochemical properties. A key aspect of astrocytic function involves calcium (Ca2+)-dependent signaling, which serves as a fundamental mechanism interactions with neurons other brain. However, while significant progress has been made understanding spatio-temporal properties Ca2+ signals, downstream molecular pathways exact mechanisms through astrocytes decode these signals regulate homeostatic physiological processes remain poorly understood. To address this topic, we review here available literature on sources intracellular Ca2+, well its signaling pathways. We well-studied Ca2+-dependent exocytosis but draw attention additional that less understood are, most likely, highly influential many cellular functions. Finally, how is thought underlie neuron-astrocyte regions involved cognitive processing.

Язык: Английский

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Coupled magneto-mechanical growth in hyperelastic materials: Surface patterns modulation and shape control in bio-inspired structures

Journal of the Mechanics and Physics of Solids, Год журнала: 2025, Номер 200, С. 106089 - 106089

Опубликована: Март 3, 2025

Язык: Английский

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Study on the stiffness and damping properties of magnetorheological elastomers subjected to biaxial loads and a magnetic field

Polymer Testing, Год журнала: 2025, Номер unknown, С. 108777 - 108777

Опубликована: Март 1, 2025

Язык: Английский

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Magneto-mechanically derived diffusion processes in ultra-soft biological hydrogels

Journal of the Mechanics and Physics of Solids, Год журнала: 2024, Номер 192, С. 105791 - 105791

Опубликована: Июль 22, 2024

Magneto-active hydrogels (MAHs) consist of a polymeric network doped with magnetic particles that enable the material to mechanically respond stimuli. This multifunctionality allows for modulation mechanical properties in remote and dynamic manner. These characteristics combined biocompatibility hydrogels, make MAHs excellent drug delivery biological scaffolds. In this work, ultra-soft strong magnetostriction are fabricated from human blood plasma (∼20 Pa). The is experimentally tested using novel in-house device precise control actuation conditions, enabling hydrogel terms deformation stiffness. We study impact on solvent expulsion diffusion dynamics within network. To further elucidate mechanisms driving processes, computational framework modeling process two different species magneto-responsive proposed. experimental outcomes open exciting new opportunities use bioengineering applications.

Язык: Английский

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Astrocyte regulation of extracellular space parameters across the sleep-wake cycle

Frontiers in Cellular Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Июнь 26, 2024

Multiple subfields of neuroscience research are beginning to incorporate astrocytes into current frameworks understanding overall brain physiology, neuronal circuitry, and disease etiology that underlie sleep sleep-related disorders. Astrocytes have emerged as a dynamic regulator activity through control extracellular space (ECS) volume composition, both which can vary dramatically during different levels arousal. also an attractive target due their prominent role in the glymphatic system, method by toxic metabolites generated wakefulness cleared away. In this review we assess literature surrounding glial influences on fluctuations ECS composition across sleep-wake cycle. We examine mechanisms astrocyte regulation solute clearance wake states. Overall, findings highlight importance research.

Язык: Английский

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Impact of Magneto‐Mechanical Actuation on Cell Differentiation: A Study Using Wireless, 3D‐Printed Device and a Porous Ferrogel

Small, Год журнала: 2025, Номер unknown

Опубликована: Янв. 7, 2025

Abstract Cells perceive external and internally generated forces of different kinds, significantly impacting their cellular biology. In the relatively nascent field mechanobiology, impact such is studied further utilized to broaden knowledge developmental pathways, disease progression, tissue engineering, developing novel regenerative strategies. However, extensive considerations mechanotransduction pathways for biomedical applications are still broadly limited due a lack affordable technologies in terms devices simple magnetic actuatable materials. Herein, synthesizing monophasic, macroporous, situ‐fabricated gelatin‐based ferrogel reported using polyethylene glycol (PEG) coated‐iron oxide (magnetite) particles with high magnetization. Developing 3D printed, compact, wireless device capable providing wide range magneto‐mechanical actuation susceptible materials noncontact manner reported. Using ferrogel, C2C12 myoblast differentiation under actuation, significant differences myogenin, marker, expression behavior observed. Due careful design considerations, robust component selection, easy availability low‐cost precursor responsive material fabrication, device‐ferrogel combination can be easily adapted routine biological studies, thereby helping mechanobiology exciting new

Язык: Английский

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In-silico platform for the multifunctional design of 3D printed conductive components

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 4, 2025

Abstract The effective electric resistivity of conductive thermoplastics manufactured by filament extrusion methods is determined both the material constituents and printing parameters. former determines multifunctional nature composite, whereas latter dictates mesostructural characteristics such as adhesion void distribution. This work provides a multi-scale computational framework to evaluate thermo-electro-mechanical behaviour printed polymers. A full-field homogenisation model first influence features (i.e., orientations, voids between filaments). Then, macroscopic continuum elucidates effects mixed boundary conditions. in-silico methodology validated with extensive original multi-physical experiments functional application consisting an electro-heatable cartridge. Overall, this establishes foundations virtually break gap mesoscopic responses in components additive manufacturing techniques.

Язык: Английский

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Multiscale measurement of brain tissue and cell biomechanics using a mouse model

Biophysics Reports, Год журнала: 2025, Номер 11, С. 1 - 1

Опубликована: Янв. 1, 2025

Язык: Английский

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Deep learning accelerates reverse design of Magnetorheological elastomer

Composites Science and Technology, Год журнала: 2025, Номер unknown, С. 111148 - 111148

Опубликована: Март 1, 2025

Язык: Английский

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TNF-α mediates activation of neuronal necroptotic signaling in rat with syringomyelia

Experimental Neurology, Год журнала: 2025, Номер 388, С. 115214 - 115214

Опубликована: Март 9, 2025

Язык: Английский

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