A Pyroptosis Radiosensitizer Facilitates Hypoxic Tumor Necrosis

Small, Год журнала: 2025, Номер unknown

Опубликована: Фев. 24, 2025

Hypoxia-related tumor radioresistance markedly impairs the efficacy of radiotherapy. Herein, a targeted radiosensitization strategy is introduced, leveraging upregulation gasdermin C (GSDMC) in hypoxic cells, aiming to induce pyroptosis through application cobalt-containing polyoxometalate-based radiosensitizer. This novel radiosensitizer designed for precisely controlled release cobalt ions upon X-ray irradiation, thereby activating caspase-8 and prompting cleavage GSDMC. sequence events selectively triggers directly addressing radioresistance. The ensuing results highlight enhanced radiotherapy necrosis both vitro vivo models. Overall, findings confirm effectiveness this targeting high GSDMC expression tumors precise Such encourage further exploration hypoxia-driven improve cancer treatment outcomes.

Язык: Английский

A Caspase 3‐Hijacking Nanosystem Enhances Cancer Radiotherapy by Suppressing Tumor Repopulation

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Окт. 18, 2024

Abstract Radiotherapy is used in the treatment of ≈50% patients with cancer. However, tumor repopulation a major cause failure after radiotherapy. It observed that apoptotic following ionizing radiation (IR) accelerated growth surviving cells. Here G asdermin E and T annic acid‐based nanoassembly (GT) loaded manganese tetroxide (Mn 3 O 4 ) (termed as Mn @GT) developed to suppress improve outcome @GT enables an increase reactive oxygen species accumulation cells, enhancing radiotherapy‐mediated killing. What's more, it can hijack activated caspase induce pyroptosis, reversing apoptosis‐mediated repopulation. In vivo results shows significantly reduced IR induced by 2.7 fold, resulting 92% complete regression tumors. addition, sensitize tumors anti‐PD‐L1 therapy inducing immunogenic pyroptosis 85% distant The 3‐hijacking nanosystem holds great potential for improving clinical benefits

Язык: Английский

Fullerenol reduces vascular injury caused by ischemia-reperfusion

Carbon, Год журнала: 2024, Номер unknown, С. 119949 - 119949

Опубликована: Дек. 1, 2024

Язык: Английский