Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Июль 1, 2024

The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements potential therapeutic applications, focusing primarily on two areas: emerging cell-based therapies promising non-cell modalities. Within context cell therapy, discuss capacity overcome existing translational challenges faced by mainstream therapy paradigms, provide a detailed discussion advantages principal design considerations for boosting efficacy as well list specific examples different disease scenarios. We then explore drug delivery, physical intervention therapies, other areas (e.g., bioadhesives, artificial tissues, biosensors), emphasizing utility beyond mere delivery vehicles. Additionally, complement our latest progress clinical application outline future research directions, particularly terms integration with advanced biomanufacturing This review aims present comprehensive view critical insights into selection both tailored meet requirements diverse diseases situations.

Язык: Английский

---

Self‐Growing Hydrogel Bioadhesives for Chronic Wound Management

Advanced Materials, Год журнала: 2024, Номер 36(41)

Опубликована: Авг. 16, 2024

Hydrogel bioadhesives have emerged as a promising alternative to wound dressings for chronic management. However, many existing do not meet the functional requirements efficient management through dynamically mechanical modulation, due reduced contractibility, frequent recurrence, incapability actively adapt external microenvironment variation, especially those gradually-expanded wounds. Here, self-growing hydrogel bioadhesive (sGHB) patch that exhibits instant adhesion biological tissues but also gradual increase in strength and interfacial adhesive within 120-h application is presented. The gradually increased mechanics of sGHB could effectively mitigate stress concentration at edge, resist expansion various stages, thus mechanically contracting wounds programmable manner. demonstrated enhanced healing efficacy mouse diabetic model, by regulating inflammatory response, promoting faster re-epithelialization angiogenesis modulation. Such kind potential clinical utility variety where dynamic modulation indispensable.

Язык: Английский

---

Innovations in Tactile Sensing: Microstructural Designs for Superior Flexible Sensor Performance

Advanced Functional Materials, Год журнала: 2024, Номер 34(44)

Опубликована: Июнь 22, 2024

Abstract Tactile sensors have garnered considerable interest for their capacity to detect and quantify tactile information. The incorporation of microstructural designs into flexible has emerged as a potent strategy augment sensitivity pressure variations, thereby enhancing linearity, response spectrum, mechanical robustness. This review underscores the imperative progress in microstructured sensors. Subsequently, discourse transitions prevalent materials employed fabrication sensor electrodes, encapsulation layers, active sensing mediums, elucidating merits limitations. In‐depth discussions are devoted adorned with microstructures, including but not limited to, micropyramids, microhemispheres, micropillars, microporous configurations, microcracks, topological interconnections, multilevel constructs, random roughness, biomimetic microstructures inspired by flora fauna, accompanied exemplar studies from each category. Moreover, utility within realm intelligent environments is explicated, highlighting application monitoring physiological signals, detection sliding motions, discernment surface textures. culminates critical examination paramount challenges predicaments that must be surmounted further development enhance functional performance sensors, paving way integration advanced sensory systems.

Язык: Английский

---

Progress in hydrogel toughening: addressing structural and crosslinking challenges for biomedical applications

Discover Materials, Год журнала: 2025, Номер 5(1)

Опубликована: Янв. 9, 2025

Achieving the ideal replacement for robust biological tissues requires biocompatible materials with a nuanced blend of characteristics, including organ specific toughness, durability, self-repairing capability, and well-defined structure. Hydrogels, structured high water containing 3D-crosslinked polymeric networks, present promising avenue in biomedical applications due to their close resemblance natural tissues. However, mechanical performance often falls short, limiting clinical applications. Recent research has been focused on developing hydrogel therapeutic advancements have spurred researchers develop hydrogels having acceptable toughness. While it is now possible tailor properties synthetic gels mimic those tissues, critical aspects such as biocompatibility crosslinking strategies are frequently neglected. This review scrutinizes structural techniques designed improve toughness hydrogels, focusing especially innovative efforts integrate these enhancements into natural-based hydrogels. By thoroughly examining methodologies, sheds light complexities strengthening will propose valuable insights development next-generation tissue substitutes.

Язык: Английский

---

Advancements in Passive Wireless Sensing Systems in Monitoring Harsh Environment and Healthcare Applications

Nano-Micro Letters, Год журнала: 2025, Номер 17(1)

Опубликована: Янв. 9, 2025

Abstract Recent advancements in passive wireless sensor technology have significantly extended the application scope of sensing, particularly challenging environments for monitoring industry and healthcare applications. These systems are equipped with battery-free operation, connectivity, designed to be both miniaturized lightweight. Such features enable safe, real-time industrial support high-precision physiological measurements confined internal body spaces on wearable epidermal devices. Despite exploration into diverse environments, development a systematic comprehensive research framework system architecture remains elusive, which hampers further optimization these systems. This review, therefore, begins an examination scenarios, progresses evaluate current architectures, discusses function each component—specifically, module, communication model, readout module—within context key implementations target sensing Furthermore, we present case studies that demonstrate feasibility proposed classified components derived from this approach. By outlining trajectory technologies, paper aims establish foundation more advanced, user-friendly

Язык: Английский

---

All 3D-printed high-sensitivity adaptive hydrogel strain sensor for accurate plant growth monitoring

Soft Science, Год журнала: 2025, Номер 5(1)

Опубликована: Янв. 16, 2025

Highly sensitive strain sensors are crucial for monitoring subtle plant growth changes and show diverse applications in sensing. However, the prevailing integrated fabrication methods such tend to be costly complex, impeding their fundamental design practical usage. Herein, we develop a simple effective multimaterial all-3D printing technique manufacture with multilayered structure. Such an all-3D-printed sensor exhibits excellent sensing performance enabling precise detection of minor strains growth, including high stretchability (> 300%), sensitivity (~12.78) good linearity (0.98), long-term stability over 3,000 loading/unloading cycles. We further validate potential our 3D-printed accurate continuous bamboo both horizontal vertical directions 14 days. Our offers promising avenue systems toward monitoring.

Язык: Английский

---

Recent progress of soft and bioactive materials in flexible bioelectronics

Cyborg and Bionic Systems, Год журнала: 2025, Номер 6

Опубликована: Янв. 1, 2025

Materials that establish functional, stable interfaces to targeted tissues for long-term monitoring/stimulation equipped with diagnostic/therapeutic capabilities represent breakthroughs in biomedical research and clinical medicine. A fundamental challenge is the mechanical chemical mismatch between implants ultimately results device failure corrosion by biofluids associated foreign body response. Of particular interest development of bioactive materials at level chemistry mechanics high-performance, minimally invasive function, simultaneously tissue-like compliance vivo biocompatibility. This review summarizes most recent progress these purposes, an emphasis on material properties such as response, integration schemes biological tissues, their use bioelectronic platforms. The article begins overview emerging classes platforms bio-integration proven utility live animal models, high performance different form factors. Subsequent sections various flexible, soft materials, ranging from self-healing hydrogel/elastomer bio-adhesive composites materials. Additional discussions highlight examples active systems support electrophysiological mapping, stimulation, drug delivery treatments related diseases, spatiotemporal resolutions span cellular organ-scale dimension. Envisioned applications involve advanced brain, cardiac, other organ systems, offer stability human subjects models. Results will inspire continuing advancements functions benign thus yielding therapy diagnostics healthcare.

Язык: Английский

---

Conducting Hydrogel‐Based Neural Biointerfacing Technologies

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Abstract Neural biointerfacing, enabling direct communication between neural systems and external devices, holds great promises for applications in brain machine interfaces, prosthetics, neuromodulation. However, current electronics made of conventional rigid materials are challenged by their inherent mechanical mismatch with the tissues. Hydrogel bioelectronics, properties compatible tissues, represent an alternative to these limitations enable next‐generation biointerfacing technology. Here, overview cutting‐edge research on conducting hydrogels (CHs) bioelectronics development, emphasizing material design principles, manufacturing techniques, essential requirements, corresponding application scenarios is presented. Future challenges potential directions regarding CHs‐based technologies, including long‐term reliability, multimodal hydrogel closed‐loop system wireless power supply system, raised. It believed that this review will serve as a valuable resource further advancement implementation

Язык: Английский

---

Highly Conductive and Stretchable Hydrogel Nanocomposite Using Whiskered Gold Nanosheets for Soft Bioelectronics

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Авг. 11, 2024

Abstract The low electrical conductivity of conductive hydrogels limits their applications as soft conductors in bioelectronics. This originates from the high water content hydrogels, which impedes facile carrier transport between fillers. study presents a highly and stretchable hydrogel nanocomposite comprising whiskered gold nanosheets. A dry network nanosheets is fabricated then incorporated into wet matrices. preserve tight interconnection despite content, providing high‐quality percolation even under stretched states. Regardless type matrix, gold‐hydrogel nanocomposites exhibit ≈520 S cm −1 stretchability ≈300% without requiring dehydration process. reaches maximum ≈3304 when density controlled. gold‐adhesive nanocomposite, can achieve conformal adhesion to moving organ surfaces, for bioelectronics demonstrations. adhesive electrode outperforms elastomer‐based electrodes vivo epicardial electrogram recording, pacing, sciatic nerve stimulation.

Язык: Английский

---

Preparation of environmental resistance and anti-swelling hydrogel through solvent displacement for monitoring human health and movement in amphibious environment

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159838 - 159838

Опубликована: Янв. 1, 2025

Язык: Английский

---