Journal of Tissue Engineering,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 1, 2025
Osteonecrosis
of
the
femoral
head
(ONFH)
is
a
prevalent
orthopedic
disorder
characterized
primarily
by
compromised
blood
supply.
This
vascular
deficit
results
in
cell
apoptosis,
trabecular
bone
loss,
and
structural
collapse
at
late
stage,
significantly
impairing
joint
function.
While
MRI
highly
effective
tool
for
diagnosing
ONFH
its
early
stages,
challenges
remain
due
to
limited
availability
high
cost
MRI,
as
well
absence
routine
screening
asymptomatic
patients.
.
In
addition,
current
therapeutic
strategies
predominantly
only
relieve
symptoms
while
disease-modifying
drugs
are
still
under
investigation/development.
Considering
that
supply
plays
key
role
pathology
ONFH,
angiogenic
therapies
have
been
put
forward
promising
treatment
options.
Emerging
bioengineering
interventions
targeting
angiogenesis
hold
potential
treatment.
this
review,
we
introduce
advances
research
into
summarize
novel
angiogenesis.
review
sheds
light
upon
new
directions
future
ONFH.
Advanced Materials,
Год журнала:
2025,
Номер
37(2)
Опубликована: Янв. 1, 2025
This
special
issue
spans
a
diverse
array
of
topics,
including
nanomedicine,
tissue
engineering,
regenerative
medicine,
organs-on-chips,
biosensing,
soft
robotics,
smart
devices,
nanofabrication,
energy
saving
and
storage,
catalysis,
spintronics,
electronics,
neuromorphic
computing.
It
showcases
the
breadth
depth
advanced
materials
research
at
Chinese
University
Hong
Kong
(CUHK),
highlighting
innovation,
collaboration,
excellence
CUHK's
scientists.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
Metastasis
is
the
leading
cause
of
death
in
patients
with
lung
cancer.
Multidisciplinary
comprehensive
treatments
(MDT),
including
surgery,
chemotherapy,
radiotherapy,
gene-targeted
therapy,
immunotherapy,
antibody-drug
conjugate
(ADC),
natural
products,
etc.,
have
been
currently
used
for
cancer
metastasis.
The
MDT
model
has
shown
promising
efficacy
against
metastasis
clinical
practice.
However,
these
therapies
some
limitations,
such
as
unusual
toxic
side
effects,
drug
resistance,
limited
indications,
and
high
costs.
Therefore,
emerging
technological
platforms
are
imperative
to
overcome
bottlenecks.
Nanomedicine
can
be
prepare
efficient
delivery
systems
owing
its
good
biocompatibility,
targeting,
responsive
release,
multidrug
codelivery
plays
an
important
role
synergistic
antimetastasis
because
optical,
acoustic,
electrical,
thermal,
magnetic
functions.
This
review
analyses
limitations
model,
briefly
outlines
advantages
nanotechnology,
introduces
nanodrug
systems,
summarizes
nanostrategies
based
on
invasion-metastasis
cascade
process,
provides
a
summary
prospects
challenges
translation
nanomedicines.
Materials Today Bio,
Год журнала:
2025,
Номер
32, С. 101773 - 101773
Опубликована: Апрель 17, 2025
Bone
and
joint
diseases
are
debilitating
conditions
that
can
result
in
significant
functional
impairment
or
even
permanent
disability.
Multiscale
metal-based
nanocomposites,
which
integrate
hierarchical
structures
ranging
from
the
nanoscale
to
macroscale,
have
emerged
as
a
promising
solution
this
challenge.
These
materials
combine
unique
properties
of
nanoparticles
(MNPs),
such
enzyme-like
activities,
stimuli
responsiveness,
photothermal
conversion,
with
advanced
manufacturing
techniques,
3D
printing
biohybrid
systems.
The
integration
MNPs
within
polymer
ceramic
matrices
offers
degree
control
over
mechanical
strength,
antimicrobial
efficacy,
manner
drug
delivery,
whilst
concomitantly
promoting
processes
osteogenesis
chondrogenesis.
This
review
highlights
breakthroughs
stimulus-responsive
(e.g.,
photo-,
magnetically-,
pH-activated
systems)
for
on-demand
therapy
their
biocomposite
hybrids
containing
cells
extracellular
vesicles
mimic
native
tissue
microenvironment.
applications
these
composites
extensive,
bone
defects,
infections,
tumors,
degenerative
diseases.
emphasizes
enhanced
load-bearing
capacity,
bioactivity,
be
achieved
through
designs.
Notwithstanding
potential
applications,
barriers
progress
persist,
including
challenges
related
long-term
biocompatibility,
regulatory
hurdles,
scalable
manufacturing.
Finally,
we
propose
future
directions,
machine
learning-guided
design
patient-specific
biomanufacturing
accelerate
clinical
translation.
bridge
innovations
macroscale
functionality,
revolutionary
force
field
biomedical
engineering,
providing
personalized
regenerative
solutions
Cyborg and Bionic Systems,
Год журнала:
2025,
Номер
6
Опубликована: Янв. 1, 2025
With
its
remarkable
adaptability,
energy
efficiency,
and
mechanical
compliance,
skeletal
muscle
is
a
powerful
source
of
inspiration
for
innovations
in
engineering
robotics.
Originally
driven
by
the
clinical
need
to
address
large
irreparable
defects,
tissue
(SMTE)
has
evolved
into
versatile
strategy
reaching
beyond
medical
applications
field
biorobotics.
This
review
highlights
recent
advancements
SMTE,
including
scaffold
design,
cell
sourcing,
usage
external
physicochemical
cues,
bioreactor
technologies.
Furthermore,
this
article
explores
emerging
synergies
between
SMTE
robotics,
focusing
on
use
robotic
systems
enhance
performance
development
biohybrid
devices
integrating
engineered
tissue.
These
interdisciplinary
approaches
aim
improve
functional
recovery
outcomes
while
inspiring
novel
technologies
at
intersection
regenerative
medicine.
Polymers,
Год журнала:
2025,
Номер
17(9), С. 1263 - 1263
Опубликована: Май 6, 2025
For
organ-on-a-chip
(OoC)
engineering,
the
use
of
biocompatible
coatings
and
materials
is
not
only
recommended
but
essential.
Extracellular
matrix
(ECM)
components
are
commonly
used
as
due
to
their
effects
on
cell
orientation,
protein
expression,
differentiation,
adhesion.
Among
most
frequently
collagen,
fibronectin,
Matrigel,
according
specific
type
intended
OoC
application.
Additionally,
such
polydimethylsiloxane
(PDMS),
thermoplastics,
chitosan,
alginate
serve
scaffolding
biomechanical
properties
biocompatibility.
Here,
we
discuss
some
employed
coating
techniques,
including
SAMs,
dip
coating,
spin
microcontact
printing,
3D
bioprinting,
each
offering
advantages
drawbacks.
Current
challenges
comprise
enhancing
biocompatibility,
exploring
novel
materials,
improving
scalability
reproducibility.
