Size Effect-based Improved Antioxidant Activity of Selenium Nanoparticles Regulating Anti-PI3K-mTOR and Ras-MEK Pathways for Treating Spinal Cord Injury to Avoid Hormone Shock-induced Immunosuppression DOI Creative Commons
Peixin Liu, Xiaodong Liu, Zihao Wu

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 6, 2024

Abstract Spinal cord injury (SCI) is a critical condition affecting the central nervous system that often has permanent and debilitating consequences, including secondary injuries. Oxidative damage inflammation are factors in pathological processes. Selenium nanoparticles have demonstrated significant antioxidative anti-inflammatory properties via non-immunosuppressive pathway; however, their clinical application been limited by inadequate stability functionality to cross blood-spinal barrier (BSCB). This study proposed synthesis method for ultra-small-diameter lentinan Se (LNT-UsSeNPs) with significantly superior reactive oxygen species (ROS) scavenging capabilities compared conventional (LNT-SeNPs). These compounds effectively protected PC-12 cells from oxidative stress-induced cytotoxicity, alleviated mitochondrial dysfunction, reduced apoptosis. In vivo studies indicated LNT-UsSeNPs efficiently penetrated BSCB inhibited apoptosis of spinal neurons. Ultimately, directly regulated PI3K-AKT-mTOR Ras-Raf-MEK-ERK signaling pathways regulating selenoproteins achieve therapy. Owing ultra-small size, exhibited strong penetration potent effects without compromising immune function. findings suggest promising candidates further development nanomedicine effective treatment SCI.

Язык: Английский

Advances of Selenium in Poultry Nutrition and Health DOI
Zijian Xu, Fazheng Ren, Ziwei Zhang

и другие.

Journal of Nutrition, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Maintaining cardiac homeostasis by translational selenium nanoparticles with rapid selenoproteins regulation to achieve radiation-induced heart prevention DOI

Ke-wei Jin,

Sujiang Shi,

Dina Huang

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160005 - 160005

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Biomaterials for Modulating the Immune Microenvironment in Rheumatoid Arthritis DOI Creative Commons

Qiaoxuan Wang,

Juan Ji,

Ding Huang

и другие.

BME Frontiers, Год журнала: 2025, Номер 6

Опубликована: Янв. 1, 2025

Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease characterized by joint swelling and bone destruction. Despite an incomplete understanding of its genesis, RA tightly linked to the intricate immunological milieu, involving disruptions in molecular signaling imbalance between innate adaptive immune systems. With advancements biomaterials science, role treatment has evolved from mere drug delivery systems therapeutic microenvironment modulators, providing drug-independent strategies for RA. In this review, we will delve into RA, focusing on contributions immunity, damage-associated patterns (DAMPs), cytokines, pathways disease’s pathogenesis inflammation. We provide detailed analysis applications novel nonpharmaceutical treatment, categorized 3 key mechanisms: biofactor pathway regulation, endogenous gas adjustment, cell modulation. The composition, form, principles, efficacy these be explored. thorough discussion topics offer fresh viewpoint guide future research directions.

Язык: Английский

Процитировано

0
Selenium nanomedicine: From basic science to clinical applications DOI
Lizhen He,

Zushuang Xiong,

Tianfeng Chen

и другие.

Chem, Год журнала: 2025, Номер unknown, С. 102493 - 102493

Опубликована: Март 1, 2025

Процитировано

0
Translational Selenium Nanoparticles Promotes Clinical Non‐small‐cell Lung Cancer Chemotherapy via Activating Selenoprotein‐driven Immune Manipulation DOI Open Access

Yanzi Yu,

Bin Xie, Jinlin Wang

и другие.

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 17, 2025

Abstract Reconstructing the tumor immune microenvironment is an effective strategy to enhance therapeutic efficacy limited by immunosuppression in non‐small‐cell lung cancer (NSCLC). In this study, it found that selenium (Se) depletion and dysfunction are present patients with advanced NSCLC compared healthy volunteers. Surprisingly, Se deficiency resulted decreased immunity accelerated rapid growth mice model, which further reveals correlation between micronutrient progression. This pioneering work achieves 500‐L scale production of nanoparticles (SeNPs) at GMP level utilizes reveal how why trace element can clinical immune‐mediated treatment against NSCLC. The results translational SeNPs promote proliferation NK cells its cytotoxicity activating mTOR signaling pathway driven GPXs regulate secretion cytokines achieve antitumor response. Moreover, a study Investigator‐initiated Trial shows supplementation combination bevacizumab/cisplatin/pemetrexed exhibits enhanced objective response rate 83.3% disease control 100%, through potentiating selenoprotein‐driven immunity. Taken together, for first time, highlights SeNPs‐enhanced

Язык: Английский

Процитировано

0
Translational selenium nanoparticles enhance NKG2D-mediated cytotoxicity of NK cells against malignant pleural mesothelioma cells through the TrxR1-pSTAT3 pathway DOI
Shaowei Liu, Xue Li, Weifeng Wei

и другие.

Nano Today, Год журнала: 2025, Номер 62, С. 102720 - 102720

Опубликована: Март 28, 2025

Язык: Английский

Процитировано

0
Triple-Functional Probiotics with Intracellularly Synthesized Selenium Nanoparticles for Colitis Therapy by Regulating the Macrophage Phenotype and Modulating Gut Microbiota DOI

Puze Li,

Lichong Zhu, Cheng Song

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

The dysregulated macrophage phenotype, as the main cause of colitis, not only enhanced oxidative stress to exacerbate inflammatory responses but was closely related with gut microbial dysbiosis. It needed simultaneously address three issues for effective treatment it satisfied. Here, we developed "three-birds-one-stone" probiotics, named Se@EcN-C2/A2, colitis treatment. Escherichia coli Nissle 1917 (EcN), a clinically approved probiotic, used intracellularly synthesize selenium (Se) nanoparticles by biomineralization, giving Se@EcN. Coating glycol chitosan and sodium alginate on surface Se@EcN (Se@EcN-C2/A2) endowed probiotics high resistance harsh gastrointestinal tract environment strong adhesion targeting ability inflamed site colon facilitate uptake M1 macrophages. Se@EcN-C2/A2 metabolized SeCys2 MetSeCys be involved in synthesis GPX2 TXNRD1, which led reaction oxygen species clearance inhibit Toll-like receptor nuclear factor κB signaling pathways suppress response polarize macrophages M2 phenotypes activating PI3K/AKT pathways. In DSS-induced mice, exerted satisfactory therapeutic prophylactic effects, including scavenging regulating restore barrier functions. Moreover, living probiotic EcN effectively regulated dysbiosis decreasing abundance Escherichia-Shigella increasing Lactobacillus Bifidobacterium.

Язык: Английский

Процитировано

0
Nanomaterials‐Based Drug Delivery Systems for Therapeutic Applications in Osteoporosis DOI

Donghong Shi,

Yuling Li,

Meng Tian

и другие.

Advanced Biology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 8, 2025

Abstract The etiology of osteoporosis is rooted in the disruption intricate equilibrium between bone formation and resorption processes. Nevertheless, conventional anti‐osteoporotic medications hormonal therapeutic regimens currently employed clinical practice are associated with a multitude adverse effects, thereby constraining their overall efficacy potential. Recently, nanomaterials have emerged as promising alternative due to minimal side efficient drug delivery, ability enhance formation, aiding restoring balance. This review delves into fundamental principles remodeling microenvironment, well current treatment approaches for osteoporosis. It subsequently explores research status nanomaterial‐based delivery systems treatment, encompassing inorganic nanomaterials, organic cell‐mimicking carriers exosomes mimics emerging therapies targeting microenvironment. Finally, discusses potential nanomedicine treating outlines future trajectory this burgeoning field. aim provide comprehensive reference application strategies therapy, fostering further advancements innovations critical area medical

Язык: Английский

Процитировано

0
GPx-Mimetic Selenium-Enriched Yeast Nanozymes Ameliorate Diabetic Bone Disease via Dual-Targeting of ROS Scavenging and Angiogenesis-Osteogenesis Coupling DOI Creative Commons
Zimei Wu,

Qiaodan Hou,

Lang Qin

и другие.

Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101836 - 101836

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Ultrasound-Driven Selenium Nanoparticles Realize Bone Defect Repair through Activating Selenoproteins to Regulate PI3K/AKT Signaling Pathway DOI
Yu‐Fan Chen, Renhao Xu, Bin Xie

и другие.

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Май 8, 2025

Excessive and variable inflammation in bone defects is a key factor that impedes effective repair. Herein, an ultrasound-controlled composite hydrogel (LNT-SeNPs@Gel) integrating gelatin-methacryloyl lentinan-decorated selenium nanoparticles (LNT-SeNPs) developed, exhibiting strong antioxidant anti-inflammatory properties to remodel the inflammatory microenvironment of defects. This serves as platform for bifunctional ultrasound (ultrasound modulation, USc repairing, USr), facilitating cascade treatment reducing overall period. During phase repair, remotely modulates LNT-SeNPs@Gel hydrogel, regulating release LNT-SeNPs inhibit overproduction reactive oxygen species (ROS) factors, ultimately remodeling microenvironment. Subsequently, USr could activate phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathway regulated by selenoproteins enhance osteogenesis MC3T3-E1 cells, thereby accelerating repair process. Consequently, combination significantly improves outcomes reduces period rats. In conclusion, this study implies coordinated integration dual effects promising strategy handling complex lengthy

Язык: Английский

Процитировано

0