Broad‐Spectrum Detoxification of Snake Venoms With Supramolecular Materials Integrated via Molecular Recognition and Coassembly DOI
Mengmeng Chen,

Han‐Wen Tian,

Yuan‐Qiu Cheng

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 4, 2024

Abstract Snakebite is a medical emergency that often leads to high mortality and morbidity in tropical subtropical regions. The diversity venom composition between various types of snakes necessitates the use different specific antivenom treatments, which presents clinical financial challenges management snakebites. Therefore, developing broad‐spectrum antidote neutralize complex diverse snake venoms has assumed critical importance. Herein, developed through molecular recognition coassembly four kinds toxins, those are three‐finger toxin (3FTx), metalloproteinase (SVMP), phospholipase A 2 (PLA ), serine protease (SVSP), have abundance toxicity. sulfonate‐modified amphiphilic calixarene (SCA) cyclodextrin (CD) employed toxicity 3FTx, 1,2‐dodecanedithiol (DDT) thioetheramide phosphorylcholine (TEAPC) introduced SVMP PLA , respectively, nafamostat (NT), can be loaded host‐guest complexation, SVSP. antidote, NT@SCA/CD/DDT/TEAPC, effectively neutralizes key toxins from most medically important cobra vipers, significantly improving survival rates poisoned mice. This study conceptually validated feasibility detoxification also offers conveniently integrated supramolecular strategy.

Язык: Английский

Nanoscale drug formulations for the treatment of Alzheimer's disease progression DOI Creative Commons

Liu Liqin,

Haini He,

Bert N. La Du

и другие.

RSC Advances, Год журнала: 2025, Номер 15(6), С. 4031 - 4078

Опубликована: Янв. 1, 2025

Alzheimer's disease (AD) is a devastating neurodegenerative disorder with no effective disease-modifying treatments.

Язык: Английский

Процитировано

2
Codelivery of fibronectin and rapamycin via bioactive phosphorus dendrimers to ameliorate Alzheimer’s disease through macrophage autophagy, oxidative stress alleviation and polarization modulation DOI
Mengsi Zhan,

Waicong Dai,

Huxiao Sun

и другие.

Nano Today, Год журнала: 2025, Номер 61, С. 102664 - 102664

Опубликована: Фев. 12, 2025

Язык: Английский

Процитировано

1
Amphiphilic Acyclic Cucurbit[n]uril: Synthesis, Self-Assembly, and Chemotherapeutic Delivery to Overcome Multidrug Resistance DOI
Zizhen Zhao,

Danying Ma,

Shuyi Wang

и другие.

Molecular Pharmaceutics, Год журнала: 2025, Номер unknown

Опубликована: Фев. 26, 2025

A new amphiphilic acyclic cucurbit[n]uril (CB[n]) is designed and synthesized. This CB[n] could encapsulate pharmaceutical drugs via a host–guest interaction. Self-assembly of this forms spherical nanoparticles with diameters 91 nm in water. The self-assembled are capable delivering doxorubicin high efficiency. Cell experiments show that the doxorubicin-loaded can improve cellular uptake cytotoxicity by using MCF-7/ADR cell line. A549 tumor-bearing mouse model shows help overcome multidrug resistance vivo. study histological assays confirm biocompatibility nanoparticles.

Язык: Английский

Процитировано

0
Fight Aβ Aggregation with Molecular Aggregates DOI Open Access
Cheng Wang, Dingxin Zhang, Ming Hu

и другие.

Macromolecular Chemistry and Physics, Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

Abstract Alzheimer's disease (AD) is the most common form of neurodegenerative disease. Aggregation amyloid‐β peptides (Aβ), a characteristic molecular event AD, may produce neurotoxic aggregates, notably oligomers that can induce series pathogenic change, finally leading to AD. Suppression Aβ aggregates‐induced neurotoxicity via intervention aggregation or removal toxic aggregates are considered as an effective approach for AD treatment. Notably, formed by assembly organic molecules have demonstrated promising potential fight due their advantages, such high binding affinity, blood‐brain barrier permeability, well synergistic effect between multiple functionalities, resulting from unique physicochemical properties in aggregate state. This review focuses on recent progress fighting terms inhibition aggregation, redirection into non‐toxic disassembly and clearance aggregates. Representative examples categorized block manner. Their structural design, working mechanism, anti‐AD highlighted. Finally, perspectives challenges aggregation‐oriented future research also proposed.

Язык: Английский

Процитировано

0
Microenvironments‐Targeted Nanomaterials for Atherosclerosis Therapy DOI
Chunli Song, Hao Ling, Guanqing Yang

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 26, 2025

Abstract Atherosclerosis significantly contributes to cardiovascular disease. Traditional treatments for atherosclerosis, such as pharmacological interventions and surgical procedures, have demonstrated limited efficacy often yield unsatisfactory results. Consequently, safe effective therapeutic strategies are urgently needed. The atherosclerotic microenvironments, characterized by inflammation driven foam cells, damaged endothelial recruited leukocytes, lipoproteins, inflammatory mediators, play a key role in disease progression. By leveraging the biological components physicochemical properties of these researchers developed microenvironments‐targeted nanomaterials promising approach treat atherosclerosis. These aim address eliminate processes. Their functions include repairing damage, reducing lipoprotein accumulation, inhibiting leukocyte chemotaxis, suppressing cell formation, delaying plaque rupture, preventing thrombosis within plaque. This review highlights mechanisms effects targeting processes microenvironments. Finally, challenges prospects nanomaterial‐based therapies atherosclerosis discussed inspire development that modulate potentially leading clinical applications.

Язык: Английский

Процитировано

0
Hybrid Lipoplex Boosts Neuron‐Microglia Crosstalk for Treatment of Alzheimer's Disease through Aβ‐Targeted‐Autophagy and ApoE2 Gene Supplementation DOI
Yiyao Pu, Xufang Dai,

Yichun Wang

и другие.

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 29, 2025

Abstract Efficient clearance of amyloid‐ β (A ) is vital but challenging in Alzheimer's disease (AD) treatment due to its complicated regulation mechanisms during generation and metabolism. It necessitates a multidimensional synergistic strategy based on ingenious delivery system design. Herein, guanidine‐rich lipids (metformin‐inspired MLS arginine‐contained RLS) are devised trigger selective chaperone‐mediated autophagy for amyloid precursor protein degradation neurons. They further co‐assembled with oleic acid‐modified cerium dioxide (OA@CeO 2 form RMC assembly pApoE2 (RMC/pApoE2 lipoplex). The OA@CeO boosts macro‐autophagy, alleviates oxidative stress inflammatory microenvironment, promotes the neurons‐microglia crosstalk A elimination. Concurrently, both benefit transfection neurons, enabling transport into microglia, facilitating enzymatic hydrolysis cellular digestion extracellular . lipoplex‐boosted neuron–microglia interactions ultimately eliminate intra‐ extra‐cellular aggregates. Consequently, RMC/pApoE2 lipoplex eliminates ≈86.9% plaques hippocampus APP/PS1 mice restored synaptic function neuronal connectivity. Moreover, it recovers spatial memory nearly level WT control. presented hybrid showcases an advanced gene system, offers promising AD treatment.

Язык: Английский

Процитировано

0
Aβ aggregation inhibition via peptide-conjugated gold nanoclusters: Mechanistic insights and therapeutic potential DOI Creative Commons
Yecheng Wang,

Si‐Cong Bai,

Xueying Hu

и другие.

Materials & Design, Год журнала: 2025, Номер unknown, С. 114032 - 114032

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Multifunctional natural chlorogenic acid based nanocarrier for Alzheimer's disease treatment DOI
Chenchen Wang, Xiaolei Song, Xiaowan Zhang

и другие.

Materials Today Bio, Год журнала: 2025, Номер 32, С. 101841 - 101841

Опубликована: Май 8, 2025

Язык: Английский

Процитировано

0
Nanoimmunomodulation of the Aβ-STING feedback machinery in microglia for Alzheimer’s disease treatment DOI Creative Commons
Limin Tian,

Guangyu Long,

Siqi Zhu

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2025, Номер 122(22)

Опубликована: Май 28, 2025

Imbalanced production and clearance of amyloid-β (Aβ) is a hallmark pathological feature Alzheimer’s disease (AD). While several monoclonal antibodies targeting Aβ have shown reductions in amyloid burden, their impact on cognitive function remains controversial, with the added risk inflammatory side effects. Dysregulated stimulator interferon genes (STING) signaling implicated neurodegenerative disorders, yet biological interaction between this pathway Aβ, as well combined influence AD progression, poorly understood. Here, we show that while microglia play protective role clearing extracellular excessive engulfment triggers cytosolic leakage mitochondrial DNA for cGAS–STING cascade. This creates negative feedback loop not only exacerbates neuroinflammation but also impairs further clearance. To address this, present nanomedicine approach termed “Aβ-STING Synergistic ImmunoSilencing Therapy (ASSIST)”. ASSIST comprises STING inhibitors encapsulated within blood–brain barrier (BBB)-permeable polymeric micelle serves an scavenger. Through multivalent mechanism, efficiently destabilizes plaques prevents monomer aggregation, subsequently promoting dissociated by rather than neurocytes. Furthermore, induced uptake blocked, reducing inflammation restoring microglial homeostatic functions involved Intravenous administration significantly reduces burden improves cognition mice, minimal cerebral angiopathy or microhemorrhages. We provide proof-of-concept nanoengineering strategy to target maladaptive immune arising from conventional immunotherapy treatment.

Язык: Английский

Процитировано

0
Inhibitory Effects of Gliadin Hydrolysates on BACE1 Expression and APP Processing to Prevent Aβ Aggregation DOI Open Access
Chin‐Yu Lin,

Cheng-Hong Hsieh,

Paul B.S. Lai

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 13212 - 13212

Опубликована: Дек. 9, 2024

Alzheimer's disease (AD), a leading neurodegenerative disorder, is closely associated with the accumulation of amyloid-beta (Aβ) peptides in brain. The enzyme β-secretase (BACE1), pivotal Aβ production, represents promising therapeutic target for AD. While bioactive derived from food protein hydrolysates have neuroprotective properties, their inhibitory effects on BACE1 remain largely unexplored. In this study, we evaluated potential gliadin, whey, and casein proteins prepared using bromelain, papain, thermolysin. Through vitro cellular assays, bromelain-hydrolyzed gliadin (G-Bro) emerged as most potent inhibitor, an IC

Язык: Английский

Процитировано

1