Modulating the Electronic Structure of MnNi2S3 Nanoelectrodes to Activate Pyroptosis for Electrocatalytic Hydrogen‐Immunotherapy
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 14, 2024
Abstract
Hydrogen
(H
2
)
therapy
has
demonstrated
antitumor
effect,
but
the
therapeutic
efficacy
is
restricted
by
low
solubility
and
nontarget
delivery
of
H
.
Electrolysis
O
electrocatalysts
sustainably
releases
enormous
amounts
inspires
precise
for
tumor
therapy.
Herein,
manganese‐doped
Ni
S
3
nanoelectrodes
(MnNi
NEs)
are
designed
electrocatalytic
activation
immunity
to
effectively
potentiate
‐immunotherapy.
atoms
featuring
empty
3d
orbitals
reduce
initial
energy
barrier
hydrogen
evolution
reaction
(HER)
promoting
adsorption
O.
Moreover,
Mn
with
different
electronegativity
modulate
electronic
structure
facilitate
desorption
generated
,
thus
enhancing
HER
activity
MnNi
NEs.
Based
on
high
activity,
controllable
(EHT)
achieved
in
a
voltage‐dependent
manner.
Mechanistically,
NE‐mediated
EHT
induces
mitochondrial
dysfunction
oxidative
stress,
which
subsequently
activates
pyroptosis
through
typical
ROS/caspase‐1/GSDMD
signaling
pathway.
Furthermore,
enhances
infiltration
CD8
+
T
lymphocytes
into
tumors
reverses
immunosuppressive
microenvironment.
This
work
demonstrates
an
electrocatalyst
synergistic
gas‐immunotherapy,
may
spark
electrocatalyst‐based
strategies.
Язык: Английский
Dual functional nanoplatforms potentiate osteosarcoma immunotherapy via microenvironment modulation
National Science Review,
Год журнала:
2025,
Номер
12(3)
Опубликована: Янв. 10, 2025
Osteosarcoma
(OS),
a
highly
aggressive
bone
tumor,
presents
significant
challenges
in
terms
of
effective
treatment.
We
identified
that
cellular
autophagy
was
impaired
within
OS
by
comparing
clinical
samples
through
bioinformatic
analyses
and
further
validated
the
inhibition
mitochondrial
at
transcriptomic
level.
Based
on
this
finding,
we
investigated
therapeutic
potential
dual
functional
metal
nanoplatform
(MnSx)
to
facilitate
transition
from
protective
effect
low-level
killing
high-level
OS.
MnSx
facilitated
intracellular
H2S
generation
via
endocytosis,
leading
S-sulfhydration
ubiquitin-specific
peptidase
8
(USP8)
subsequent
promotion
vitro.
Additionally,
activated
cyclic
guanosine
monophosphate-adenosine
monophosphate
synthase
(cGAS)-stimulator
interferon
genes
(STING)
pathway,
enhancing
autophagic
response
accelerating
tumor
cell
death.
Moreover,
it
demonstrated
vivo
MnSx,
one
hand,
mediated
activation
USP8
H2S,
while
Mn2+
promoted
maturation
dendritic
cells,
cytotoxic
T
lymphocytes
contributed
eradication.
Such
could
be
suppressed
inhibitor
chloroquine.
Importantly,
synergistic
combination
therapy
with
immune
checkpoint
inhibitors
showed
promise
for
achieving
complete
remission
This
study
highlights
as
dual-functional
platform
treatment
offers
novel
directions
future
research
field.
Язык: Английский
Nanosensitizer-assisted sonodynamic therapy for breast cancer
Jing Yu,
Jun-Rui Hu,
Yi Tian
и другие.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Апрель 7, 2025
Abstract
Breast
cancer
is
the
most
commonly
diagnosed
worldwide.
Despite
advancements
in
therapeutic
modalities,
its
prognosis
remains
poor
owing
to
complex
clinical,
pathological,
and
molecular
characteristics.
Sonodynamic
therapy
(SDT)
a
promising
approach
for
tumor
elimination,
using
sonosensitizers
that
preferentially
accumulate
tissues
are
activated
by
low-intensity
ultrasound
produce
reactive
oxygen
species.
However,
clinical
translation
of
SDT
faces
challenges,
including
limited
efficiency
resistance
posed
microenvironment.
The
emergence
nanomedicine
offers
innovative
strategies
address
these
obstacles.
This
review
discusses
enhancing
efficacy
sonosensitizers,
rational
structural
modifications,
improved
tumor-targeted
enrichment,
microenvironment
remodeling,
imaging-guided
therapy.
Additionally,
SDT-based
multimodal
therapies,
such
as
sono-chemotherapy,
sono-immunotherapy,
sono-photodynamic
therapy,
their
potential
applications
breast
treatment
summarized.
underlying
mechanisms
briefly
outlined.
Finally,
this
highlights
current
challenges
prospects
SDT,
providing
insights
into
future
may
improve
outcomes
cancer.
Graphical
abstract
Язык: Английский
Microbial Photosynthetic Oxygenation and Radiotherapeutic Sensitization Enables Pyroptosis Induction for Combinatorial Cancer Therapy
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 26, 2025
Abstract
Rectal
cancer
surgery
is
challenging
due
to
the
complex
anatomy,
making
it
difficult
achieve
clear
surgical
margins.
Radiotherapy
(RT)
plays
a
crucial
role,
especially
in
treating
locally
recurrent
rectal
and
preserving
anal
function.
However,
its
effectiveness
often
limited
by
tumor
hypoxia,
particularly
prevalent
hypoxic
regions
near
bowel
wall
colorectal
cancer.
Hypoxia
contributes
both
radiation
resistance
apoptosis
resistance,
compromising
RT
outcomes.
To
overcome
hypoxia‐driven
radiotherapy
this
work
designs
engineers
radiotherapy‐sensitizing
bioplatform
for
efficient
RT.
It
combines
lanthanum
oxide
nanoparticles
(La
2
O
3
NPs)
with
cyanobacteria,
which
produces
oxygen
through
photosynthesis.
This
uniquely
reduces
enhances
deposition,
improves
efficacy.
La
NPs
further
enhance
reactive
species
(ROS)
production
induced
radiation,
triggering
pyroptosis
via
ROS‐NLRP3‐GSDMD
pathway,
while
amplifies
GSDME,
circumventing
resistance.
The
integrated
thermosensitive
hydrogels
ensure
precise
localization
of
bioplatform,
reducing
systemic
toxicity
improving
therapeutic
specificity.
Compared
conventional
therapies,
dual‐action
system
addresses
more
effectively.
In
vivo
vitro
hypoxia
models
validate
potent
anti‐tumor
efficacy,
offering
valuable
insights
refining
clinical
treatment
paradigms.
Язык: Английский
Zinc–Nickel Bimetallic Hydroxide Nanosheets Activate the Paraptosis–Pyroptosis Positive Feedback Cycle for Enhanced Tumor Immunotherapy
ACS Nano,
Год журнала:
2024,
Номер
18(43), С. 29913 - 29929
Опубликована: Окт. 15, 2024
Immunotherapy
holds
significant
promise
for
cancer
treatment.
However,
the
highly
immunosuppressive
nature
of
solid
tumors
limits
its
effectiveness.
Herein,
we
developed
bioactive
zinc–nickel
hydroxide
(ZnNi(OH)4)
nanosheets
(NSs)
that
can
effectively
initiate
paraptosis–pyroptosis
positive
feedback
cycle
through
synergistic
ionic
effect,
thereby
mitigating
immunosuppression
and
enhancing
efficacy
immunotherapy.
The
acid-sensitive
ZnNi(OH)4
NSs
releases
Ni2+
Zn2+
in
weakly
acidic
tumor
microenvironment.
released
alleviated
pyroptosis
inhibition
by
inducing
paraptosis
inhibiting
autophagic
flux.
Concurrently,
triggered
release
endogenous
within
cell
a
coordination
competition
mechanism,
further
amplifying
zinc
overload-mediated
pyroptosis.
Interestingly,
pyroptosis-associated
oxidative
stress
endoplasmic
reticulum
promote
Ni2+-mediated
paraptosis,
forming
loop
between
paraptosis.
This
process
not
only
kills
cells
but
also
stimulates
strong
inflammatory
response,
antitumor
immune
response
immunotherapy
efficacy.
Overall,
this
study
proposes
an
effective
induction
strategy
based
on
metal
ions
demonstrates
effectiveness
potentiating
Язык: Английский
Antimony Component Schottky Nanoheterojunctions as Ultrasound‐Heightened Pyroptosis Initiators for Sonocatalytic Immunotherapy
Angewandte Chemie,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 21, 2024
Abstract
Pyroptosis,
an
inflammatory
modality
of
programmed
cell
death
associated
with
the
immune
response,
can
be
initiated
by
bioactive
ions
and
reactive
oxygen
species
(ROS).
However,
ion‐induced
pyroptosis
lacks
specificity,
further
exploration
other
that
induce
in
cancer
cells
is
needed.
Sonocatalytic
therapy
(SCT)
holds
promise
due
to
its
exceptional
penetration
depth;
however,
rapid
recombination
electron‐hole
(e
−
‐h
+
)
pairs
complex
tumor
microenvironment
(TME)
impede
broader
application.
Herein,
we
discovered
antimony
(Sb)‐based
nanomaterials
induced
cells.
Therefore,
Schottky
heterojunctions
containing
Sb
component
(Sb
2
Se
3
@Pt)
were
effectively
designed
constructed
via
situ
growth
platinum
(Pt)
nanoparticles
(NPs)
on
semiconductor
narrow
band
gaps,
which
utilized
as
US‐heightened
initiators
highly
effective
boost
SCT‐immunotherapy.
Under
US
irradiation,
excited
electrons
transferred
from
nanorods
(NRs)
co‐catalyst
Pt
junctions,
bending
prevented
electron
backflow
achieved
efficient
ROS
generation.
Moreover,
pores
oxidized
depleted
overexpressed
GSH
TME,
potentially
amplifying
The
biological
effects
@Pt
nanoheterojunction
itself
combined
sonocatalytic
amplification
oxidative
stress
significantly
Caspase‐1/GSDMD‐dependent
SCT
treatment
not
only
restrained
proliferation
but
also
potent
memory
responses
suppressed
recurrence.
Furthermore,
integration
this
innovative
strategy
checkpoint
blockade
(ICB)
elicited
a
systemic
augmenting
therapeutic
impeding
abscopal
tumors.
Overall,
study
provides
opportunities
explore
pyroptosis‐mediated
Язык: Английский