Recent advances in nanomaterials and their mechanisms for infected wounds management

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101553 - 101553

Опубликована: Фев. 5, 2025

Wounds infected by bacteria pose a considerable challenge in the field of healthcare, particularly with increasing prevalence antibiotic-resistant pathogens. Traditional antibiotics often fail to achieve effective results due limited penetration, resistance development, and inadequate local concentration at wound sites. These limitations necessitate exploration alternative strategies that can overcome drawbacks conventional therapies. Nanomaterials have emerged as promising solution for tackling bacterial infections facilitating healing, thanks their distinct physicochemical characteristics multifunctional capabilities. This review highlights latest developments nanomaterials demonstrated enhanced antibacterial efficacy improved healing outcomes. The mechanisms are varied, including ion release, chemodynamic therapy, photothermal/photodynamic electrostatic interactions, delivery drugs, which not only combat but also address challenges posed biofilms antibiotic resistance. Furthermore, these create an optimal environment tissue regeneration, promoting faster closure. By leveraging unique attributes nanomaterials, there is significant opportunity revolutionize management wounds markedly improve patient

Язык: Английский

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Semiconducting Perylene Diimide J‐aggregates Cross‐linked Hydrogel Enables High‐Efficiency Photothermal Controlled Release of Nitric Oxide for Antibiofilm Therapy

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 9, 2025

Antibiofilm treatment, particularly drug-containing wound healing dressings, does not typically penetrate the robust protective extracellular polymeric substance of biofilm and eradicate bacteria. Here, a rational design nitric oxide (NO) donor N,N'-di-sec-butyl-N,N'-dinitroso-1,4-phenylenediamine (BNN6)-based injectable hydrogel, is reported in which NO release can be triggered by photothermal effect owing to semiconducting perylene diimide (PDI) J-aggregation fibers. The synthetic PDI derivatives self-assembling into 0D nanoparticles then aggregating 1D J fiber accompanied absorbance red-shifting from 700 790 nm 852 nm. After encapsulating BNN6, "sandwich roll" (SR) like structure evenly crosslinked an hydrogel (SRH) exhibiting high convenience efficiency 72%, enables SRH achieve highly efficient photocontrol release. shows excellent injectability, shape adaptability, effective antibacterial efficacy over 99% E.coli S. aureus. remarkable vivo antibiofilm 99.58% laser irradiation. Furthermore, synergistic treatment displays ability eliminate inflammation, facilitate angiogenesis, promote collagen deposition, thereby significantly stimulating process wounds. versatile strategy for biofilm.

Язык: Английский

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Polyphenol‐Modified Mg−Zn Layered Hydroxide‐Contained Microneedle Patch Enhance Mucosal Repair by Remolding Diabetic Oral Microenvironment

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 10, 2025

Abstract Diabetic oral ulcers pose a significant challenge in healing due to persistent inflammation. Despite local therapeutic interventions remaining the primary mode of treatment, dynamic nature cavity, characterized by continuous muscular activity and salivary secretion, poses barriers sustained drug retention thereby limits efficacy. To address this issue, an approach has been devised that aims facilitate transdermal delivery bioactive components promote diabetic ulcers. A multifunctional soluble microneedle (MN) patch is prepared using γ‐polyglutamic acid (γ‐PGA), which loaded with quercetin (Qu)‐modified Mg−Zn layered hydroxide salt (LHS) nanosheets (LHSQ) anti‐inflammatory, antimicrobial pro‐angiogenic bioactivities combat These findings demonstrate LHSQ‐loaded MN (LHSQ‐MN) patches are capable effectively penetrating mucosa. In rat model ulcers, application LHSQ‐MN found establishment regeneration sites, regulate inflammatory microenvironment damaged tissues, exhibit potent antibacterial effects, expedite reconstitution mucosal epithelium, accelerate ulcer through promotion angiogenesis. outcomes highlight potential as promising strategy for management patients.

Язык: Английский

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Advanced biomaterials for targeting mature biofilms in periodontitis therapy

Bioactive Materials, Год журнала: 2025, Номер 48, С. 474 - 492

Опубликована: Фев. 27, 2025

Язык: Английский

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Construction of CeO2/Ti3C2Tx heterojunction with antibacterial and antioxidant capabilities for diabetic wound healing

Journal of Colloid and Interface Science, Год журнала: 2025, Номер 689, С. 137247 - 137247

Опубликована: Март 4, 2025

Язык: Английский

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A Tailored Hydrogel With Local Glycemia Management, Antioxidant Activity, and Photothermal Antibacterial Properties for Diabetic Wound Healing

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

The management of chronic diabetic wounds is a complex challenge requiring local glycemic regulation, modulation inflammation levels, and prevention bacterial infections. Therefore, multifunctional wound dressing with antioxidant, glycocontrol, antibacterial properties developed to promote healing. This constructed by co-loading gold-cerium oxide (AuCeO2) dumbbells glucose oxidase (GOx) into reactive oxygen species (ROS)-sensitive hydrogel matrix (ACG gels). In this system, Au-CeO2 effectively eliminate ROS, protecting cells from oxidative stress-induced damage while exhibiting significant near-infrared photothermal activity. Additionally, the controlled release GOx decreases blood levels in microenvironment, alleviating stress inhibiting growth proliferation, thereby expediting healing process. ACG gels demonstrated excellent healing-promoting two vivo models, providing promising effective platform for management.

Язык: Английский

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Tailoring Versatile Nanoheterojunction-Incorporated Hydrogel Dressing for Wound Bacterial Biofilm Infection Theranostics

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Wound-infected bacterial biofilms are protected by self-secreted extracellular polymer substances (EPS), which can confer them with formidable resistance to the host's immune responses and antibiotics, thus delays in diagnosis treatment cause stubborn infections life-threatening complications. However, tailoring an integrated theranostic platform capability promptly diagnose treat wound biofilm infection still remains a challenge. Herein, versatile erbium-doped carbon dot-encapsulated zeolitic imidazolate framework-8 (Er:CDs@ZIF-8) nanoheterojunction (C@Z nano-HJ) is tailored incorporated into gelatin methacrylate/poly(N-hydroxyethyl acrylamide) (GelMA/PHEAA)-based tough sticky hydrogel dressing (GH-C@Z) achieve infection-integrated application. Stimulated acidic microenvironment of biofilm, turn-on response C@Z assists monitoring exhibiting cyan fluorescence. Meanwhile, effectively destroy EPS barrier accomplish photothermal-photodynamic-ion interference synergistic antibacterial therapy under near-infrared light. Furthermore, after effective eradication potent antioxidant properties released Er:CDs allow attenuate reactive oxygen species mitigate inflammatory responses, finally promote collagen deposition neovascularization accelerate healing. Overall, this provides insight development diagnostic therapeutic platforms for infections.

Язык: Английский

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Vacancies-Rich Z-Scheme VdW Heterojunction as H2S-Sensitized Synergistic Therapeutic Nanoplatform against Refractory Biofilm Infections

Biomaterials, Год журнала: 2025, Номер 320, С. 123258 - 123258

Опубликована: Март 13, 2025

Язык: Английский

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Mild photothermal-driven nanorobots for infected wound healing through effective photodynamic therapy and wound microenvironment remodeling

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 162255 - 162255

Опубликована: Апрель 1, 2025

Язык: Английский

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One‐End‐Opened Yolk–Shell Copper Single‐Atom Microrobots for Enhanced Penetration and Eradication of Bacterial Biofilms

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 11, 2025

Abstract Single‐atom catalysts (SACs) hold remarkable potential for antibacterial and multidrug‐resistant Staphylococcus aureus (MRSA) biofilm eradication, but passive diffusion often restricts their effectiveness. In contrast, microrobots can harness various energy sources highly autonomous movement. Herein, a one‐end‐opened yolk–shell microrobot with Cu single atoms anchored on carbon nitride (Y‐CuSA/CN) is designed to enhance MRSA penetration effects. The Y‐CuSA/CN achieves single‐atom‐driven propulsion by generating an H 2 O gradient via Fenton‐like reaction. Furthermore, UV‐LED light (365 nm) excitation produces photogenerated electrons, which promotes the valence cycling of single‐atom reacts , thereby further boosting microrobot's mobility catalytic activity. exhibits vigorous movement velocity 17.2 µm s −1 rate 7.2 significantly enhancing its into bacterial biofilms. During motion, reactive oxygen species (·OH, ·O − 1 ) are released oxidation. vitro in vivo experiments demonstrate that effectively eradicates biofilms wound healing infected mice. This study presents efficient strategy eradicating highlights SACs developing advanced biomedical applications.

Язык: Английский

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