“Thermal bubbles”: Photothermally triggered by a carbon monoxide nanocontainer for antibiosis and immune modulation therapy

Nano Today, Год журнала: 2025, Номер 63, С. 102758 - 102758

Опубликована: Апрель 14, 2025

Язык: Английский

---

A dynamically phase-adaptive regulating hydrogel promotes ultrafast anti-fibrotic wound healing

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Апрель 20, 2025

Achieving rapid and scar-free wound repair is a key goal in the field of regenerative medicine. Herein, dynamically Schiff base-crosslinked hydrogel (F/R gel) with phase-adaptive regulating functions constructed to integratedly promote re-epithelization suppressed scars on chronic infected wounds. Specifically, gel effectively eliminates multidrug-resistant bacterial biofilm at infection stage via antimicrobial activity ε-polylysine firstly dissociated from matrix infectious microenvironment, interrupts severe oxidative stress-inflammation cycle site by released ceria nanozyme, thus stimulating pro-regenerative environment ensure tissue repair. Subsequently, fibroblast growth factor/c-Jun siRNA co-loaded microcapsules gradually disintegrate release drugs, facilitating neoangiogenesis cell proliferation but simultaneously blocking c-Jun overexpression for fibrotic scar suppression. Notably, F/R facilitates normal-like skin regeneration no perceptible formed male mouse female rabbit ear models. Our work offers promising strategy emphasizing immunomodulatory subtype modulation scarless

Язык: Английский

---

Hybrid Hydrogel with Photothermal Stimulation Elicits Immunomodulation‐Mediated Wound Healing

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 27, 2024

Abstract It is of paramount importance to maintain the thermal environment wounds in order facilitate optimal tissue repair and regeneration. Nevertheless, their potential as a hyperthermia regenerative therapy remains be fully elucidated. In this study, photothermal hybrid hydrogel constructed through simple “one‐step” activation process that elicits mild stimulation presented, thereby providing stable cycling capability activating immune response, accelerating restoration redox homeostasis, ultimately promoting wound healing. The results demonstrate application HGBM an impaired healing model, which exhibited elevated levels reactive oxygen species, enhanced responses, promotion macrophage polarization M2/M1, inducing pro‐regenerative response. RNA‐sequencing data at 45 °C enhances response respiratory burst process, regulating microenvironment injured tissues. Furthermore, transition from inflammatory state anti‐inflammatory pro‐healing state, promoted by production factors such interleukin‐10 interleukin‐4. This work therefore provides effective strategy for context skin

Язык: Английский

---

Overheated Self‐Managing Cellulose Nanocage Dressing by Reconstructing Hydrogen Bonds Networks

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Дек. 13, 2024

Abstract Interfacing intelligent responsive molecules with biocompatible nanofibers is a promising strategy for developing overheated self‐managing photothermal dressings convenient and cost‐effective clinical applications. Here, an anisotropic staggered cellulose nanocage dressing properties constructed by temperature‐responsive flexible triblock copolymer Pluronic ® F‐127 interpenetrating smart nanofiber network skeleton, which interfaced white light (635 nm) protoporphyrin IX, NIR‐I (808 dopamine, NIR‐II (980 upconversion nanoparticles. Ingeniously, the can release 1 O 2 produce heat energy under stimulation continuous natural laser during anti‐inflammation phase, respectively, further promote formation of new capillaries producing NO epithelial stage laser. Interestingly, dressing, resembled water droplets, penetrate adapt to irregular wounds via sol–gel transformation at 32 °C, while also facilitating management self‐cooling regulation reconstruction its hydrogen bond driven overheating temperatures (>50 °C). The proposed method overcomes shortcoming requiring auxiliary strategies temperature monitoring, providing insights guiding design practical dressings.

Язык: Английский

---

Surface-Functionalized Bacteria: Frontier Explorations in Next-Generation Live Biotherapeutics

Biomaterials, Год журнала: 2024, Номер 317, С. 123029 - 123029

Опубликована: Дек. 15, 2024

Язык: Английский

---