Recent advances on biomedical applications of zirconium-based Nanozymes: A review

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 159464 - 159464

Опубликована: Янв. 1, 2025

Язык: Английский

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Inverse Oxide/Alloy‐Structured Nanozymes with NIR‐Triggered Enzymatic Cascade Regulation of ROS Homeostasis for Efficient Wound Healing

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

The precise spatiotemporal control of reactive oxygen species (ROS) generation and scavenging remains pivotal for infected wound healing. However, conventional nanozymes fail to adaptively regulate ROS dynamics across inflammatory proliferative phases. A near-infrared (NIR)-activated inverse oxide/alloy-structured nanozyme (Co7Fe3/ZnO@C) is developed, featuring enzymatic cascade activities tune homeostasis through synergistic chemodynamic (CDT), photodynamic (PDT), photothermal (PTT) therapies. orchestrates a self-regulated cascade: peroxidase (POD)-like activity initially generates bactericidal hydroxyl radicals in acidic wounds, while subsequent NIR triggers hot electron transfer from Co7Fe3 ZnO, facilitating synchronized superoxide dismutase (SOD)-like, catalase (CAT)-like radical antioxidant capacity (HORAC) scavenge residual ROS. This cascaded network dynamically balances production (POD) (NIR-driven SOD/CAT/HORAC), eradicating bacteria resolving inflammation. In vitro/vivo studies have shown that the proposed method maintaining can markedly enhance rate healing by regulation environment within injured tissue facilitation rapid re-epithelialization. work provides an intelligent platform simulates function natural enzymes constructs reaction strategy balance antibacterial anti-inflammatory demands microenvironment.

Язык: Английский

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Hollow FeNi Prussian blue nanocages with enhanced peroxidase-mimicking activity for colorimetric detection of mercury ions and L-cysteine

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161080 - 161080

Опубликована: Фев. 1, 2025

Язык: Английский

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Nanozymes: a bibliometrics review

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Ноя. 13, 2024

As novel multifunctional materials that merge enzyme-like capabilities with the distinctive traits of nanomaterials, nanozymes have made significant strides in interdisciplinary research areas spanning science, bioscience, and beyond. This article, for first time, employed bibliometric methods to conduct an in-depth statistical analysis global demonstrate progress, hotspots trends. Drawing on data from Web Science Core Collection database, we comprehensively retrieved publications 2004 2024. The burgeoning interest across various nations indicated a growing widespread trend. article further systematically elaborated activities, matrix, properties, catalytic mechanisms applications nanozymes, field encounters challenges. Despite notable requires deeper exploration guide future directions. harbors broad potential developments, promising impact aspects technology society.

Язык: Английский

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Spatiotemporally Guided Single‐Atom Bionanozyme for Targeted Antibiofilm Treatment

Small, Год журнала: 2024, Номер unknown

Опубликована: Окт. 6, 2024

Abstract The heterogeneous and dynamic microenvironment of biofilms complicates bacterial infection treatment. Nanozyme catalytic therapy has recently been promising in treating biofilm infections. However, active nanozymes designed with the required precision targeting are lacking. This work proposes a spatiotemporally guided single‐atom bionanozyme (BioSAzyme) for targeted antibiofilm based on protein engineering copper nanozyme (Cu SAzyme). Cu SAzyme, synthesized via novel mechanochemistry‐assisted method, features highly accessible Cu–N 4 sites exposed 2D N‐doped carbon, exhibiting excellent triple enzyme‐like activities according to experimental results density functional theory calculations. Inheriting biofunctionality from both glucose oxidase concanavalin A, BioSAzyme can localize glycocalyx catalyze endogenous into H₂O₂ gluconic acid, thus triggering multiplex cascade reactions pH self‐adaption consume glutathione generate •OH radicals. bionanocatalytic agent effectively inhibits E. coli O157: H7 methicillin‐resistant S. aureus vitro vivo. Taking together, this opens up new avenues rational design precise therapy.

Язык: Английский

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Efficiently selective inactivation of Gram-positive bacteria by MCM-41 molecular sieve-supported copper-based self-cascading nanozymes

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160948 - 160948

Опубликована: Фев. 1, 2025

Язык: Английский

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Nose-to-brain delivery of gold nanozyme with cascade effect for bacterial meningitis therapy

Rare Metals, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

Язык: Английский

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Co-assembly of antimicrobial polypeptoids/carbon dots for internal-external cooperated sterilization

Journal of Colloid and Interface Science, Год журнала: 2025, Номер 690, С. 137292 - 137292

Опубликована: Март 10, 2025

Язык: Английский

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Synthesis of bimetallic compounds derived from Polyvinylpyrrolidone modified-FeMo2S3 and ZnMo2S3 Mo-clusters and their antibacterial application against water-borne microorganisms

Tungsten, Год журнала: 2025, Номер unknown

Опубликована: Март 18, 2025

Язык: Английский

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Reshaping bacterial microenvironments: Hybrid biomimetic membrane-coated copper nanosystems combat bacterial biofilm infections by inhibiting bacterial quorum sensing systems

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 162088 - 162088

Опубликована: Апрель 1, 2025

Язык: Английский

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