Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 158569 - 158569
Опубликована: Дек. 1, 2024
Язык: Английский
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Март 5, 2025
MXene-based materials have attracted significant interest due to their distinct physical and chemical properties, which are relevant fields such as energy storage, environmental science, biomedicine. MXene has shown potential in the area of tissue regenerative medicine. However, research on its applications regeneration is still early stages, with a notable absence comprehensive reviews. This review begins detailed description intrinsic properties MXene, followed by discussion various nanostructures that can form, spanning from 0 3 dimensions. The focus then shifts biomaterials engineering, particularly immunomodulation, wound healing, bone regeneration, nerve regeneration. MXene's physicochemical including conductivity, photothermal characteristics, antibacterial facilitate interactions different cell types, influencing biological processes. These highlight modulating cellular functions essential for Although developing, versatile structural attributes suggest role advancing
Язык: Английский
Процитировано
6
Clinical Orthopaedics and Related Research, Год журнала: 2025, Номер unknown
Опубликована: Фев. 19, 2025
Background Rotator cuff tears are common, affecting more than 60% of individuals older 80 years, and they have been implicated in 70% patients with shoulder pain. M1 polarization-related inflammation has reported to be associated poor healing outcomes rotator injury, leptin, an adipokine, a potential activator inflammation. However, whether leptin affects repair remains unknown. Questions/purposes Using vitro cell experiments vivo rat tear model, we therefore asked: (1) Does promote the polarization macrophages vivo? (2) impair biomechanical strength, histologic structure tendon-bone interface, bone mineral density (BMD), or gait scenario? (3) by upregulating tumor necrosis factor (TNF) pathway? Methods The impact on macrophage was determined reverse transcription–polymerase chain reaction (RT-PCR), Western blot test, immunofluorescence staining. effect assessed model comparing group suture terms gait, tensile BMD. In experiments, 8-week-old male Sprague Dawley rats were used, adapting previously developed model. supraspinatus tendon resected from greater tuberosity bilaterally, then secured its anatomical footprint using transosseous single-row technique. total, 30 randomized into two groups (suture, leptin) drawing lots (15 each group). They at 2, 4, 8 weeks after surgery. group, 100 µL normal saline injected subacromial space deltoid muscle restitched original position. solution (200 ng/mL) Biomechanical properties including maximal failure load, stiffness, stress assess strength 4 Histologic staining conducted compare interface between treatment groups. Micro-MRI micro-CT assessments overall outcome BMD Gait analysis stride length Finally, explore underlying mechanism effects Necrostatin-1 (Nec-1) used block TNF signaling pathway study, RT-PCR mechanism. Results Leptin enhanced LPS-induced vitro, showing increased gene expression CD86, Nos2, TNF-α as well protein TNF-α, interleukin-6 (IL-6), inducible NO synthase (iNOS). showed that promoted. At 2 postoperatively, there cells (53 ± 5 versus 77 8, mean difference 24 [95% confidence interval (CI) 11 37]; p = 0.002), although proportion (ratio number total macrophages) not higher (18.6% 2.9% 21.5% 1.7%, CI -2.8% 8.7%]; 0.36). exhibited (31 50 6, 19 6 32]; 0.008) (16.4% 2.6% 23.0% 3.0%, 6.6% 0.8% 12.4%]; 0.03). impaired healing. both different load (12.7 1.6 N 12.4 1.8 N, -0.3 -2.6 1.8]; 0.91), stiffness (5.1 0.7 N/mm 4.6 0.8 N/mm, -0.5 -1.3 0.5]; 0.44), (2.0 0.3 2.0 , 0.0 -0.4 0.4]; 0.99). worse (17.6 1.4 14.1 -3.5 -5.7 -1.3]; (7.0 0.6 5.2 -1.8 -2.7 -0.9]; < 0.001), (3.4 2.8 0.4 -0.6 -1.0 -0.2]; 0.007). staining, image assessments, also demonstrated process. upregulated molecules pathway, CCL2 receptor-interacting kinase 1 (RIPK1), markers, such Nos2; addition Nec-1 neutralized polarization, reducing blocking RIPK. similar trends. Conclusion Based results this appears tear, upregulate polarization. Clinical Relevance Obesity fatty infiltration tears. adipose factor, explored. Future studies might focus developing novel approaches improve obesity targeting aid biomaterials.
Язык: Английский
Процитировано
2
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101460 - 101460
Опубликована: Янв. 5, 2025
Chirality is one of the basic characteristics living matter, yet effect chiral polymers on osteogenesis seldom studied. Thus, it necessary to deeply recognize behaviors in osteogenic processes, which can be beneficial for development bone repair materials. In this work, hydroxyapatite (HAP) was constructed simply using poly(levorotatory/dextral-tartaric acid) as guest transfer system. We studied influence HAPs migration and differentiation pre-osteoblasts, angiogenesis endothelial cell vitro. The results showed that poly(levorotatory-tartaric acid)-induced HAP did promote vascular remodeling exhibited excellent impact osteogenetic by improving related gene protein expression, whereas no significant change observed poly(dextral-tartaric or poly(racemic-tartaric induced HAP, respectively. This study highlighted effects potential, laid groundwork biomaterials regeneration.
Язык: Английский
Процитировано
0
Bioactive Materials, Год журнала: 2025, Номер 47, С. 460 - 480
Опубликована: Фев. 13, 2025
Язык: Английский
Процитировано
0
The Innovation Life, Год журнала: 2025, Номер unknown, С. 100138 - 100138
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Advanced Functional Materials, Год журнала: 2024, Номер unknown
Опубликована: Дек. 26, 2024
Abstract Chirality, the property of objects that are nonsuperimposable on their mirror images, plays a crucial role in biological processes and cellular behaviors. Chiral engineered biomaterials have emerged as promising approach to regulating fate regenerative medicine. However, few reviews provide comprehensive examination recent advancements chiral applications regulation. Herein, various fabrication techniques available for biomaterials, including use molecules, surface patterning, self‐assembly discussed. The mechanisms through which influence responses, such modulation adhesion receptors, intracellular signaling, gene expression, explored. Notably, demonstrated ability guide stem cell differentiation augment tissue‐specific functions. potential musculoskeletal disorders, neurodegenerative diseases, cardiovascular wound healing highlighted. Challenges future perspectives, standardization methods translation clinical settings, addressed. In conclusion, offer exciting prospects precisely controlling fate, advancing medicine, enabling personalized therapeutic strategies.
Язык: Английский
Процитировано
2
Advanced Science, Год журнала: 2024, Номер unknown
Опубликована: Дек. 31, 2024
Inspired by the fundamental attribute of chirality in nature, chiral-engineered biomaterials now represent a groundbreaking frontier biomedical fields. However, integration within inorganic materials remains critical challenge and developments chirality-induced bionic bone implants are still infancy. In this view, novel chiral hydroxyapatite (CHA) coated Ti alloys successfully synthesized sophisticated molecule-induced self-assembly method for first time. The obtained samples characterized stereospecific L-/D-/Rac-chiral hierarchical morphology, nanotopography rough surfaces, improved hydrophilicity, bioactivity. Following implantation into rat femoral condyle defects, distinct structures exhibit highly enantioselective bone-implants interactions, wherein left-handed L-CHA strongly promotes osteoporotic osseointegration vice versa right-handed D-CHA. Consistently, vitro assays further validate superior enantiomer-dependent ability L-CHA, mainly manipulating desired immunomodulation coupled with enhanced neurogenesis, angiogenesis, osteogenesis. Moreover, as analyzed transcriptomic RNA-seq, new discovery down-regulated IL-17 signaling pathway is considered predominately responsible L-CHA. These results provide insights biological multifunctionality mechanism underlying L-chirality's roles healing, thus may inspiring generation biomaterials.
Язык: Английский
Процитировано
1
Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 158569 - 158569
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0