Wound Repair and Regeneration,
Год журнала:
2025,
Номер
33(3)
Опубликована: Май 1, 2025
ABSTRACT
Delayed
wound
healing
and
non‐healing
wounds
are
common
in
diabetic
patients
due
to
the
hostile
microenvironments
complex
pathophysiology
of
wounds.
Addressing
these
challenges
remains
a
significant
concern
for
clinicians
researchers.
Recently,
microneedle
technology
has
emerged
as
an
effective,
minimally
invasive
delivery
system
treating
wounds,
offering
ease
use
efficient
drug
delivery.
Naturally
derived
biomaterial‐based
microneedles
have
demonstrated
excellent
biocompatibility,
degradability,
low
toxicity,
enhancing
process
by
providing
mechanical
support
delivering
antimicrobial
agents,
growth
factors,
antioxidants.
Some
designed
adapt
specific
leading
improved
outcomes.
This
review
summarises
design
development
naturally
discusses
mechanisms
action
response
varying
conditions.
The
also
addresses
critical
considerations
developing
microenvironment‐response
microneedles,
highlighting
implications
translational
medicine.
Collectively,
interdisciplinary
collaboration
technological
innovation
advanced
creation
using
natural
biomaterials,
which
hold
potential
improving
healing.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 21, 2025
Abstract
Healing
of
chronic
wounds
becomes
a
global
health
issue
due
to
increasing
incidence
and
associated
burdens,
therefore
promoting
tissue‐remodeling
monitoring
wound‐status
visually
are
particular
significance.
Herein,
an
electronic‐skin
patch
(TENG‐gel)
composed
by
polydimethylsiloxane/polytetrafluoroethylene
film,
eutectic
gallium–indium
(E‐GaIn),
quaternary
chitosan/polyacrylamide/sodium
alginate@molybdenum
disulfide
(MoS
2
)
nanosheet
(H
QPS
@MoS
composite
hydrogel
is
assembled
layer‐by‐layer.
First,
the
TENG‐gel
realizes
multimodal
antibacterial
integrating
peroxidase‐like
activity,
photothermal
therapy,
nano‐knife
effect,
which
eliminates
both
Gram‐positive/negative
bacteria
with
killing
ratio
above
95%.
Besides,
electrical
stimulation
generated
from
promotes
migration
fibroblasts
after
incubation
48
h
activating
signaling
pathways,
meanwhile
accelerates
vascularization
secreting
different
growth
factors
CD31,
VEGF,
TGF‐β.
Through
providing
ideal
microenvironment
for
tissue
repair,
achieves
1.6‐fold
new
hair
follicles
2.4‐fold
collagen
deposition
compared
those
control
group.
More
interestingly,
dual
temperature‐/strain‐sensing
performance
enables
capability
wound
status
or
reminding
external
danger
signals
in
real‐time
dependent
on
variational
signals.
Overall,
unique
advantages
such
smart
provide
personalized
medicine
strategy
realizing
reconstruction
synchronously.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 20, 2024
Periodontitis
is
a
chronic
inflammatory
disease
caused
by
dental
plaque,
which
leads
to
tooth
loosening
and
shifting
or
even
loss.
Current
treatments,
including
mechanical
debridement
antibiotics,
often
fail
eradicate
recalcitrant
biofilms
mitigate
excessive
inflammation.
Moreover,
these
interventions
can
disrupt
the
oral
microbiome,
potentially
compromising
long-term
treatment
outcomes.
To
address
limitations,
an
injectable
nanoenzyme
hydrogel
composed
of
dopamine
(DA)-modified
hyaluronic
acid
(HA)
scaffold
graphdiyne-iron
(GDY-Fe)
complex,
named
GDY-Fe@HA-DA,
exhibits
excellent
tissue
adhesion,
self-healing,
antibacterial
properties,
biocompatibility.
Under
near-infrared
laser
irradiation,
GDY-Fe@HA-DA
effectively
eradicates
variety
pathogens,
Escherichia
coli,
Staphylococcus
aureus,
Porphyromonas
gingivalis,
through
synergistic
combination
chemodynamical
photothermal
therapies.
The
hydrogel's
efficacy
further
validated
in
both
bacterial-infected
skin
wounds
rat
periodontitis
models.
It
alleviates
environment
promotes
wound
healing
periodontal
recovery.
This
findings
highlight
potential
as
promising
therapeutic
material
for
other
injuries.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
13(32)
Опубликована: Окт. 14, 2024
Abstract
Chronic
wounds
are
characterized
by
long‐term
inflammation,
including
diabetic
ulcers,
traumatic
etc.,
which
provide
an
optimal
environment
for
bacterial
proliferation.
At
present,
antibiotics
the
main
clinical
treatment
method
chronic
wound
infections.
However,
overuse
of
may
accelerate
emergence
drug‐resistant
bacteria,
poses
a
significant
threat
to
human
health.
Therefore,
there
is
urgent
need
develop
new
therapeutic
strategies
Nanozyme‐based
antimicrobial
therapy
(NABT)
emerging
strategy
with
broad‐spectrum
activity
and
low
drug
resistance
compared
traditional
antibiotics.
NABT
has
shown
great
potential
as
catalyzing
generation
reactive
oxygen
species
(ROS)
its
enzyme‐like
catalytic
properties,
producing
powerful
bactericidal
effect
without
developing
resistance.
cascade
technology
offers
approach
infection
control,
effectively
improving
efficacy
activating
cascades
against
cell
membranes
intracellular
DNA
while
minimizing
side
effects.
it
worth
noting
that
this
still
in
early
stages
research.
This
article
comprehensively
reviews
classification,
current
methods
infection,
different
types
nanozymes,
application
nanozyme
reaction
therapy,
future
challenges
prospects.
Micromachines,
Год журнала:
2025,
Номер
16(4), С. 426 - 426
Опубликована: Апрель 2, 2025
The
development
of
micro-
and
nano-fabrication
technologies
has
greatly
advanced
single-cell
spatial
omics
technologies.
With
the
advantages
integration
compartmentalization,
microfluidic
chips
are
capable
generating
high-throughput
parallel
reaction
systems
for
screening
analysis.
As
improve,
can
now
integrate
promising
transcriptomics
technologies,
providing
new
insights
from
molecular
characterization
tissue
gene
expression
profiles
further
revealing
static
even
dynamic
processes
tissues
in
homeostasis
disease.
Here,
we
survey
current
landscape
methods
field
multi-omics,
as
well
assessing
their
relative
limitations.
We
highlight
how
microfluidics
been
adapted
improved
to
provide
into
multi-omics
over
past
decade.
Last,
emphasize
contributions
microfluidic-based
development,
neuroscience,
disease
mechanisms,
some
perspectives
technological
advances
translational
clinical
medicine.
Abstract
The
resistance
and
immune
evasion
of
methicillin‐resistant
Staphylococcus
aureus
(MRSA)
in
biofilms
are
the
culprits
behind
persistent
infections.
There
is
an
urgent
need
for
safe
effective
antibacterial
strategies
to
address
MRSA
biofilm‐related
Herein,
we
propose
development
all‐in‐one
optical
microfiber
that
integrates
rapid
quantitative
analysis
with
synergistic
antimicrobial
therapy
deep‐seated
biofilms.
prepared
interfacial‐functionalized
sensor
can
be
used
clinical
whole‐blood
samples
low
volumes
(10
μL),
reducing
detection
time
30
min
effectively
preventing
false‐positive
false‐negative
results.
also
multimode
therapy.
This
one‐time
treatment
accelerates
recovery
prevents
recurrence
through
effect
photothermal
therapy,
photodynamic
Ag
+
,
as
well
activation
memory.
localized
relatively
hyperthermia
does
not
cause
harm
surrounding
healthy
tissues.
integration
therapeutic
agents
onto
precludes
their
enrichment
other
organs.
light
guided
fiber
reach
biofilms,
which
sources
fail
reach.
work
promising
diagnosis
image
