Magnetic Nanoactuator-Protein Fiber Coated Hydrogel Dressing for Well-Balanced Skin Wound Healing and Tissue Regeneration

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Янв. 3, 2025

Despite significant progress in skin wound healing, it is still a challenge to construct multifunctional bioactive dressings based on highly aligned protein fiber coated hydrogel matrix for antifibrosis regeneration that indistinguishable native skin. In this study, "dual-wheel-driven" strategy adopted modify the surface of methacrylated gelatin (GelMA) with magnetic nanocomposites-protein assemblies (MPF) consisting photothermal responsive antibacteria superparamagnetic nanocomposites-fibrinogen (Fg) complexes as building blocks. Whole-phase healing properties modified dressing, GelMA-MPF (GMPF), stem from integration Fg RGD peptide activity decorated antibacterial nanoactuator, facilitating facile and reproducible dressing preparation by self-assembly involving biochemical, morphological, biophysical cues. Payload substantial release copper ions

Язык: Английский

---

Electrostatically Stabilized Light-Activated Membrane Delivery System: Overcoming Membrane Flexibility and Self-Repair to Enhance Tumor Therapy

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Март 19, 2025

Cell membrane-coated nanoparticle-based delivery systems often struggle with inevitable drug leakage during the process and inefficient release at tumor site, resulting in unsatisfactory antitumor outcomes. Here, we present an electrostatically stabilized light-activated membrane system (Hybrid nanoparticles, [Hm]@NPs) for leak-free delivery, coupled precisely site-specific controllable release, to elevate cancer treatment. [Hm]@NPs are constructed by encapsulating aggregation-induced emission (AIE) photosensitizer (Phenalen-1-one-quinoline malonitrile-thiophene tribenamine, Phe-Qui-T) into a positively charged reactive oxygen species (ROS)-responsive polymer (F127-TP-U11) form nanoparticle then coating it negatively hybrid containing red blood cell Panc-1 membrane. high stability effectively prevent through electrostatic interaction between nanoparticle. Simultaneously, Phe-Qui-T light-controlled ROS generation efficiently destroys both ROS-responsive membrane, ensuring precise sufficient while enabling photodynamic therapy (PDT), thereby augmenting efficacy. show impressive inhibition pancreatic mouse models, highlighting potential of this membrane-disruption strategy advanced nanodelivery design.

Язык: Английский

---

NIR‐II AIEgens for Infectious Diseases Phototheranostics

Angewandte Chemie International Edition, Год журнала: 2024, Номер 63(51)

Опубликована: Авг. 26, 2024

Abstract Pathogenic infectious diseases have persistently posed significant threats to public health. Phototheranostics, which combines the functions of diagnostic imaging and therapy, presents an extremely promising solution block spread pathogens as well outbreak epidemics owing its merits a wide‐spectrum activity, high controllability, non‐invasiveness, difficult acquire resistance. Among multifarious phototheranostic agents, second near‐infrared (NIR‐II, 1000–1700 nm) aggregation‐induced emission luminogens (AIEgens) are notable by virtue their deep penetration depth, excellent biocompatibility, balanced radiative nonradiative decay aggregation‐enhanced theranostic performance, making them ideal option for combating pathogens. This minireview provides systematical summary latest advancements in NIR‐II AIEgens with emphasis on molecular design nanoplatform formulation fulfill high‐efficiency treating bacterial viral pathogens, classified disease models. Then, current challenges, potential opportunities, future research directions presented facilitate further progress this emerging field.

Язык: Английский

---

As Aggregation‐Induced Emission Meets with Noncovalent Conformational Locks: Subtly Regulating NIR‐II Molecules for Multimodal Imaging‐Navigated Synergistic Therapies

Angewandte Chemie International Edition, Год журнала: 2024, Номер 64(1)

Опубликована: Сен. 21, 2024

Phototheranostics is growing into a sparking frontier in disease treatment. Developing single molecular species synchronously featured by powerful absorption capacity, superior second near-infrared (NIR-II) fluorescence and prominent photothermal conversion ability highly desirable for phototheranostics, yet remains formidably challenging. In this work, we propose design philosophy that the integration of noncovalent conformational locks (NoCLs) with aggregation-induced emission (AIE) formulation able to boost multiple photophysical properties efficient phototheranostics. The introduction NoCLs skeleton conformation-locking feature center architecture indeed elevates structural planarity rigidity, which simultaneously promotes capacity bathochromic-shifts wavelength centered NIR-II region. Meanwhile, AIE tendency mainly originated from flexibly propeller-like geometry at ends eventually endows molecule satisfactory intensity aggregates. Consequently, utilizing optimized molecule, unprecedented performance on fluorescence-photoacoustic-photothermal trimodal imaging-guided photothermal-chemo synergistic therapy demonstrated precise tumor diagnosis complete ablation.

Язык: Английский

---

Jellyfish‐Inspired Artificial Spider Silk for Luminous Surgical Sutures

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Июль 30, 2024

Abstract The development of functional surgical sutures with excellent mechanical properties, good fluorescence, and high cytocompatibility is highly required in the field medical surgeries. Achieving fibers that simultaneously exhibit robustness, spinnability, durable fluorescence emission has remained challenging up to now. Taking inspiration from spinning process spider silk luminescence mechanism jellyfish, this work reports a luminous artificial prepared aim balancing fiber spinnability robustness. This realized by employing hydrated segments aggregation‐induced for enhancing polyhydroxyl increasing Twist insertion during improves strength, toughness, emission. Furthermore, coating an additional polymer layer results “sheath–core” architecture improved properties capacity withstand water. provides new design strategy performing luminescent robust sutures.

Язык: Английский

---

Stimuli‐Responsive Dual‐Emission Property of Single‐Luminophore‐Based Materials

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Сен. 25, 2024

Abstract Single luminophore enabling stimuli‐responsive dual‐emission characteristic has received considerable interest in recent years due to its special advantages advanced optical events. A large number of reports around the globe have involved dynamic or adjustable phenomenon (e.g., dual emission intensity ratio) single‐emitter based systems. However, a systematic overview summarizing underlying mechanisms, behaviors, and applications this topic is, so far, missing. To further promote development extend important role such kind materials diverse communities, review, latest advancements field single‐luminophore that exhibit characteristics are summarized. The discussion is centered on photophysical innovative design approaches, strategies for modulating properties, these This review anticipated provide new insights into distinctive organic luminescence community from perspective.

Язык: Английский

---

Multi-Aryl Pyrroles: Exploring Aggregation-Induced Emission for the Biological/Medical Applications

Dyes and Pigments, Год журнала: 2025, Номер unknown, С. 112633 - 112633

Опубликована: Янв. 1, 2025

Язык: Английский

---

3D Tumor-Mimicking Phantom Models for Assessing NIR I/II Nanoparticles in Fluorescence-Guided Surgical Interventions

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 6, 2025

ABSTRACT Fluorescence image-guided surgery (FIGS) offers high spatial resolution and real-time feedback but is limited by shallow tissue penetration autofluorescence from current clinically approved fluorophores. The near-infrared (NIR) spectrum, specifically the NIR-I (700-900 nm) NIR-II (950-1700 nm), addresses these limitations with deeper improved signal-to-noise ratios. However, biological barriers suboptimal optical performance under surgical conditions have hindered clinical translation of NIR-I/II nanoprobes. In vivo mouse models shown promise, do not replicate complex scenarios encountered during real-world surgeries. Existing tissue-mimicking phantoms used to evaluate imaging systems are useful fall short when assessing nanoprobes in environments. These often fail tumor microenvironment, limiting their predictive assessment. To overcome challenges, we propose developing tumor-mimicking phantom (TMPs) that integrate key features, such as tunable cell densities, -like nanoparticle concentrations, biologically relevant factors (pH, enzymes), light absorption components (hemoglobin), scattering (intralipid). TMPs enable more assessments nanoprobes, including profiling, margin delineation, ex thoracic on porcine lungs. can be further modulated closely match profiles tumors. Additionally, 3D bioprinting technology facilitates a high-throughput platform for screening realistic conditions. This approach will identify high-performing probes superior utility, bridging gap between preclinical findings applications, ensuring results extend beyond traditional studies. TOC

Язык: Английский

---

Structure–Activity Relationship of Hemicyanine Molecules: Mitochondrion-Targeting Hemicyanine Fluorescent Molecular Probes for HSO₃^– Recognition and Near-Infrared Image-Guided Photothermal/Photodynamic Synergetic Therapy

The Journal of Physical Chemistry Letters, Год журнала: 2025, Номер unknown, С. 1746 - 1752

Опубликована: Фев. 10, 2025

Hemicyanine molecules have unparalleled potential in the fields of fluorescence sensing, bioimaging, and disease therapeutics due to their excellent optical properties, cell penetration, mitochondrial targeting, photosensitivity. Herein, three dual-cation hemicyanine molecular probes named DCy, PDCy, TDCy were developed. All them could detect HSO3-, PDCy recognize HSO3- under 365 nm ultraviolet light or sunlight. In addition, is a multifunctional molecule, which has following advantages: simple synthesis, red near-infrared dual-channel imaging, photothermal/photodynamic synergistic therapy capabilities. Upon analysis correlation between structures recognition, photosensitivity, photothermal activity, cytotoxicity, structure-activity relationship be summarized, provide guidance for subsequent research development.

Язык: Английский

---

Macrophage membrane enveloped on double-locked nanoplatform with right-side-out orientation to improving precise theranostic for atherosclerosis

Journal of Controlled Release, Год журнала: 2025, Номер 380, С. 800 - 817

Опубликована: Фев. 18, 2025

Язык: Английский

---