A self-assembling nanoplatform for pyroptosis and ferroptosis enhanced cancer photoimmunotherapy

Light Science & Applications, Год журнала: 2025, Номер 14(1)

Опубликована: Янв. 2, 2025

Abstract The microenvironment of immunosuppression and low immunogenicity tumor cells has led to unsatisfactory therapeutic effects the currently developed nanoplatforms. Immunogenic cell death, such as pyroptosis ferroptosis, can efficiently boost antitumor immunity. However, exploration nanoplatform for dual function inducers combined immune activators that simultaneously trigger ferroptosis remains limited. Herein, a multifunctional pH-responsive theranostic (M@P) is designed constructed by self-assembly aggregation-induced emission photosensitizer MTCN-3 immunoadjuvant Poly(I: C), which are further encapsulated in amphiphilic polymers. This found have characteristics cancer targeting, pH response, near-infrared fluorescence imaging, lysosome targeting. Therefore, after targeting lysosomes, M@P cause dysfunction through generation reactive oxygen species heat under light irradiation, triggering cells, achieving immunogenic enhancing immunotherapy effect with C). anti-tumor been demonstrated vivo experiment 4T1 tumor-bearing mouse model poor immunogenicity. research would provide an impetus well novel strategy enhanced photoimmunotherapy.

Язык: Английский

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Hydrogen Bond‐Mediated Self‐Assembly of Carbon Dots Enabling Precise Tuning of Particle and Cluster Luminescence for Advanced Optoelectronic Applications

Advanced Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 19, 2024

The effective control over the self-assembly process of carbon dots (CDs) and their cluster luminescence in aggregated state is paramount significance challenge. This study, for first time, systematically explores photoluminescent behavior CDs state, which less understood compared to discrete state. By investigating effects concentration solvent environment, it's demonstrated that could exhibit dual emission properties, shifting from blue particle emissions red as they aggregate. key this tunable lies hydrogen bonding, drives modulates photo physical properties. These findings reveal through precise aggregation, can be engineered advanced optoelectronic applications, including light-emitting diodes (LEDs), secure information encryption, fingerprint authentication. report not only deepens understanding underlying mechanisms governing CDs' but also introduces a novel approach exploiting unique properties technological innovation.

Язык: Английский

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Size Inhomogeneity Facilitates Exciton Dissociation in Carbon Dots

Nano Letters, Год журнала: 2025, Номер 25(6), С. 2554 - 2560

Опубликована: Янв. 31, 2025

Organic carbon dots (CDs) exhibit tunable electronic structures and exceptional optical properties, supporting both exciton- charge-driven applications. However, the mechanisms underlying this dual functionality are poorly understood. This study establishes role of size inhomogeneity in exciton dissociation for first time. Two distinct CD types were identified, each class with a deviation. Intradot relaxation within same type CDs composes fast (∼1 ps) slow (∼tens picoseconds) component among size-deviated subpopulations. Interdot transfer between two occurs time scale 4.4 ps but is evident only when higher-energy states excited. It also facilitates dissociation, generating nearly free carriers, confirmed by EPR spectra (g-value = 2.005). These findings highlight critical energy level alignment selective excitation mediating providing key insights optimizing light emission conversion

Язык: Английский

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Carbon dots derived from organic drug molecules with improved therapeutic effects and new functions

Nanoscale, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

This article reviews the functions of drug-derived CDs compared with their precursors and demonstrates broad application prospects in biomedicine.

Язык: Английский

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Creating Single Atomic Coordination for Hypoxia‐Resistant Pyroptosis Nano‐Inducer to Boost Anti‐Tumor Immunotherapy

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 19, 2025

Abstract General synthesis and mechanical understanding of type I nano‐photosensitizers are great importance for hypoxia‐resistant pyroptosis inducers. Herein, a simple solvothermal treatment is developed to convert non‐photosensitive small molecules (hemin) into uniform carbon nanodots (HNCDs) with strong photodynamic activity red fluorescence emission. These HNCDs inherit the single atomic Fe–N 4 center hemin while creating sp 2 ‐hybridized surroundings, which synergistically modulated energy level electron transfer converting II process I. After encapsulating bovine serum albumin (BSA) facilitate in vivo applications, resulting BSA nanoparticles (HB) can image tumors significantly induce tumor cells even under an extremely hypoxic environment (2% O ). This evokes antitumor immune response, effectively restraining growth lung metastasis triple‐negative breast cancer mice, good biocompatibility. work introduces applicable nano‐inducer combat highlights regulation centers develop treatment.

Язык: Английский

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Construction of a Microenvironment‐Responsive Antibacterial Hydrogel Packed With Immunomodulatory Carbonized Polymer Dots for Periodontitis Treatment From Multiple Perspectives

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 28, 2025

Abstract Periodontitis is an increasingly prevalent oral inflammatory disease, whose treatment faces potent challenges because of recurrent bacterial infections, excessive reactive oxygen species (ROS) production, as well unrelenting inflammation‐induced alveolar bone resorption during the pathological process. Herein, we present rational design and construction a multifunctional hydrogel platform composed quaternized chitosan/oxidized dextran (QCS/OD) component with high bactericidal activity immunomodulatory carbonized polymer dots from resveratrol (RSV‐CPDs) for periodontitis treatment. Such RSV‐CPDs@QCS/OD (RCQD) hydrogels exhibit characteristics including shape adaptability, self‐healing properties, pH‐responsibility, enabling it to adapt irregularly shaped periodontal tissues, degrade gradually in mildly acidic microenvironment periodontitis, release RSV‐CPDs controlled manner. Significantly, RCQD can effectively suppress proliferation bacteria alleviate oxidative stress, relieve inflammation via activating Nrf2/NF‐κB signaling pathway, ultimately fostering favorable environment regeneration both soft hard tissue. Overall, this study highlights great potential treating by addressing practical needs tissue regeneration.

Язык: Английский

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Ternary CD/Co3O4@MnCo2O4 heterojunction nanozymes for enhanced sonodynamic/NIR-II-photothermal/nanocatalytic therapy through triple amplification of ROS generation

Carbon, Год журнала: 2025, Номер unknown, С. 120118 - 120118

Опубликована: Фев. 1, 2025

Язык: Английский

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A Multifunctional Nanoplatform Based on Carbon Nanotubes Loaded with Persistent Luminescent Nanoparticles for Photocatalysis, Photothermal Therapy, and Drug Delivery Applications

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер 17(9), С. 13592 - 13604

Опубликована: Фев. 18, 2025

Persistent luminescent nanoparticles (PLNPs) exhibit ultralong afterglow properties due to their excellent light storage mechanism and great potential for biomedical, energy, environmental applications. However, PLNPs have certain limitations regarding photogenerated carrier separation efficiency, absorption range, specific surface area, which limit efficiency performance in practical Herein, we reported a multifunctional nanoplatform based on carbon nanotubes (CNTs) loaded with (ZnGa1.97O4:Cr0.01, Bi0.02, ZGO). Experimental characterizations density functional theory calculations showed that the combination of CNTs significantly reduced recombination carriers PLNPs, increased enhanced intensity near-infrared (NIR) region. By optimizing ratio, ZGO-10CNTs not only exhibited greatest photocatalytic activity pollutant degradation but also generating reactive oxygen species, demonstrating therapy In addition, demonstrated NIR photothermal conversion pH-responsive drug release. The integration led development capabilities degradation, therapy, delivery, thus expanding design nanoplatforms PLNPs. construction this provides new strategies cancer opens up perspectives applications energy fields.

Язык: Английский

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Photon-triggered pyroptosis and ferroptosis dual-functional nanoplatform for cancer immunotherapy

Light Science & Applications, Год журнала: 2025, Номер 14(1)

Опубликована: Фев. 27, 2025

Abstract A dual-functional nanoplatform is demonstrated that found to have the characteristics of cancer cell targeting, pH response, near-infrared fluorescence imaging, and lysosome targeting. It can simultaneously achieve pyroptosis ferroptosis under mediation photons for immunotherapy.

Язык: Английский

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Dual-mode thermochromic afterglow in phosphorus-doped carbon dot composites for visible light-activated information encryption

Journal of Colloid and Interface Science, Год журнала: 2025, Номер 690, С. 137331 - 137331

Опубликована: Март 14, 2025

Язык: Английский

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