Navigating a challenging path: precision disease treatment with tailored oral nano-armor-probiotics

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Фев. 1, 2025

Язык: Английский

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Intelligent sequential degradation hydrogels by releasing bimetal-phenolic for enhanced diabetic wound healing

Journal of Controlled Release, Год журнала: 2025, Номер 378, С. 961 - 981

Опубликована: Янв. 1, 2025

Язык: Английский

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Recent advances in nanomaterials and their mechanisms for infected wounds management

Materials Today Bio, Год журнала: 2025, Номер 31, С. 101553 - 101553

Опубликована: Фев. 5, 2025

Wounds infected by bacteria pose a considerable challenge in the field of healthcare, particularly with increasing prevalence antibiotic-resistant pathogens. Traditional antibiotics often fail to achieve effective results due limited penetration, resistance development, and inadequate local concentration at wound sites. These limitations necessitate exploration alternative strategies that can overcome drawbacks conventional therapies. Nanomaterials have emerged as promising solution for tackling bacterial infections facilitating healing, thanks their distinct physicochemical characteristics multifunctional capabilities. This review highlights latest developments nanomaterials demonstrated enhanced antibacterial efficacy improved healing outcomes. The mechanisms are varied, including ion release, chemodynamic therapy, photothermal/photodynamic electrostatic interactions, delivery drugs, which not only combat but also address challenges posed biofilms antibiotic resistance. Furthermore, these create an optimal environment tissue regeneration, promoting faster closure. By leveraging unique attributes nanomaterials, there is significant opportunity revolutionize management wounds markedly improve patient

Язык: Английский

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A versatile nanoplatform with excellent biofilm permeability and spatiotemporal ROS regulation for peri-implantitis treatment

Theranostics, Год журнала: 2025, Номер 15(8), С. 3490 - 3516

Опубликована: Фев. 24, 2025

Rationale: Dental implant restoration is essential for rehabilitating dentition defects. However, peri-implantitis (PI) seriously threatens the long-term stability of implants. Treating PI requires complete eradication plaque biofilm and meticulous modulation inflammatory responses. Antibacterial photodynamic therapy (aPDT) presents a promising potential in antibacterial realm. Nonetheless, traditional aPDT faces challenges such as inadequate penetration distribution photosensitizers, well lack precise bacteria targeting. Moreover, excessive ROS generated by will aggravate oxidative stress peri-implant tissues, this issue cannot be neglected. Methods: The CuTA-Por@ε-PL nanoplatforms (CPP NPs) were synthesized characterized using dynamic light scattering, transmission electron microscopy, dye probes detail. anti-inflammatory activities CPP NPs evaluated both vitro vivo. vivo therapeutic efficacy was successively analyzed through micro-CT, hematoxylin eosin staining, Masson's immunofluorescence colony formation units (CFU), among other techniques. Results: Porphyrin (Por), CuTA nanozyme with SOD/CAT activities, ε-Polylysine (ε-PL) combined to fabricate via straightforward approach. notable positive charge facilitated penetration, Then, irradiation 660 nm laser triggered burst elimination. After aPDT, scavenged residual modulated host immunity regulating macrophage polarization. As result, CPP-treated groups demonstrated most outstanding performance rat model. Conclusions: Given pathogenesis PI, strategy rationally designed multifunctional NP functions spatiotemporal regulation. It provides potentially novel approach treatment, which may have profound impact on improving prognosis patients advancing field dentistry.

Язык: Английский

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Ultrafast enzyme-responsive hydrogel for real-time assessment and treatment optimization in infected wounds

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 8, 2025

Monitoring wound infection and providing appropriate treatment are crucial for achieving favorable outcomes. However, the time-consuming nature of laboratory culture tests may delay timely intervention. To tackle this challenge, a simple yet effective HDG hydrogel, composed hydrogen peroxide (H₂O₂), dopamine, GelMA polymer, is developed ultrafast detection Staphylococcus aureus (SA) infections. The hydrogel detects SA by exploiting its secreted catalase to catalyze H₂O₂, producing oxygen, which in turn accelerates polymerization colorless dopamine into deep brown polydopamine (PDA). bacterial process takes only 10 min with high sensitivity, results can be readily recognized naked eye or quantified using cell phone-based digital analysis. Moreover, provides dual antibacterial mechanism through chemical photothermal therapies via generated PDA, significantly improving clearance. In animal experiments, demonstrated promising capabilities monitoring eliminating bacteria, enhancing collagen deposition, reducing inflammation, promoting healing infected wounds. This multifunctional design offers an enzyme-responsive strategy rapid assessment management infections, simplifying evaluation facilitating development advanced dressings.

Язык: Английский

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Multienzyme-Activity Sulfur Quantum Dot Nanozyme-Mediated Cascade Reactions in Whole-Stage Symptomatic Therapy of Infected Bone Defects

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Фев. 12, 2025

Integrating the therapeutic efficacy of early bacterial clearance, midstage inflammatory remission, and late-stage effective tissue healing is considered a pivotal challenge in symptomatic treatment infected bone defects (IBDs). Herein, microenvironment-adaptive nanoplatform based on sulfur quantum dot (SQD) nanozyme was proposed for whole-stage therapy IBDs by mediating sequence enzyme cascade reactions. The SQD prepared size-engineering modification strategy exhibits enhanced multienzyme activity compared to conventional micrometer- nanometer-sized particles. In stages infection, self-activates superoxide dismutase-peroxidase activity, resulting production reactive oxygen species (ROS) that effectively eliminate bacteria. After disinfection, self-switched dismutase-catalase mimetic behavior eliminated excess ROS, efficiently promoting macrophage polarization an anti-inflammatory phenotype midinflammatory microenvironment. Importantly, nanozyme-mediated M2 significantly improved damaged immune microenvironment, accelerating repair at healing. Therefore, this offers promising viable approach infectious developing multienzyme-activity nanozymes respond intelligently microenvironment different stages, fighting bacteria, reducing inflammation, regeneration therapy.

Язык: Английский

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Reprogram Local Electronic Configuration in Multicomponent Covalent–Organic Frameworks for Efficient Hydrogen Peroxide Photoproduction

Chemistry of Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 19, 2025

Covalent organic frameworks (COFs) have recently demonstrated significant potential for photocatalysis. Optimizing the local electronic environment in COFs has been considered to be critical enhancing photocatalytic activity. Here, we report a one-pot "grafting-to" strategy reprogram configurations of series isoreticular multicomponent by introducing electron-donating or electron-withdrawing groups into pores transform photoinert photoactive and form intramolecular donor–acceptor (D-A) structures. Such D-A structures enhanced overall hydrogen peroxide photoproduction facilitating charge carrier separation optimizing band achieve oxygen reduction reaction water oxidation simultaneously. Notably, one incorporated with 2-aminothiazole exhibits production rate 3701 μmol g–1 h–1 solar-to-chemical conversion efficiency 0.13% without use any sacrificial reagents, it 100% bacterial killing rates remarkable >90% biofilm removal capability. This COF modification strategy, which not reported before, offers unique approach constructing highly active photocatalysts containing great future design antibacterial therapies.

Язык: Английский

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Photothermal Coordination Polymer with Temperature‐Induced Molecular Deformation for Efficient Interfacial Evaporation and Catalysis

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 23, 2025

Abstract Solar‐powered interfacial evaporation presents a sustainable approach for water purification, but the presence of volatile organic compounds (VOCs like phenol) poses significant challenges to its efficacy. Herein, an innovative catalytic evaporator constructed from Balsa wood functionalized with coordination polymers (cobalt‐1,5‐diamino‐4,8‐dihydroxyanthraquinone, Co‐DDA) is introduced. This multifunctional Co‐DDA exhibits both conductive and characteristics, facilitating photothermal catalysis within integrated platform. The resultant achieves impressive rate 3.23 kg m −2 h −1 energy efficiency 89.0% under one‐sun irradiation. Notably, local heat‐induced molecular deformation polymer facilitates reduction in barrier persulfate adsorption, as supported by experimental simulation data. effect promotes activation generate more reactive oxygen species, resulting remarkable 97.0% degradation 50 mg L phenol. Furthermore, Co‐DDA‐Balsa demonstrates exceptional long‐term salt resistance high antimicrobial activity, ensuring efficient, stable, eco‐friendly solar‐driven purification. work sheds light on development evaporators highly efficient VOC removal during evaporation.

Язык: Английский

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A poly(tannic acid) particle-supported β-glucan/chitosan hydrogel for managing oral ulcers in diabetes

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 306, С. 141609 - 141609

Опубликована: Фев. 28, 2025

Язык: Английский

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Injectable carboxymethyl chitosan/konjac glucomannan/catechin hydrogel with free radical-scavenging, antimicrobial, and pro-healing abilities for infected wound repair

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142572 - 142572

Опубликована: Март 1, 2025

Язык: Английский

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