Cascade-Type Microglial Pyroptosis Inhibitors for Enhanced Treatment of Cerebral Ischemia-Reperfusion Injury
ACS Nano,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 6, 2025
Neuroinflammation
is
a
critical
factor
in
the
progression
of
cerebral
ischemia-reperfusion
injury
(CIRI).
Pyroptosis,
which
an
inflammatory
form
programmed
cell
death,
greatly
amplifies
neuroinflammatory
processes.
It
does
so
by
promoting
release
various
contents
that
intensify
overall
response
within
central
nervous
system.
Therefore,
targeting
pyroptosis
represents
promising
therapeutic
strategy
for
treatment
CIRI.
Excessive
generation
reactive
oxygen
species
(ROS)
overactivated
microglia
considered
to
serve
as
signal
molecule
triggers
NLRP3
inflammasome-mediated
pyroptosis.
However,
current
inhibitors
solely
focus
on
eliminating
existing
ROS
or
inhibiting
inflammasome
are
not
optimal.
Here,
coating
nanothylakoids
(NTs)
coengineered
with
fibrin-binding
peptide
and
MG1
onto
dihydrotanshinone
I
(DT)-loaded
nanocarriers,
we
have
developed
cascade-type
inhibitor
(MDN-MC)
comprehensively
regulates
ROS/NLRP3/pyroptosis
axis.
The
incorporation
catalase
surface
MDN-MC,
along
DT,
facilitated
cascade
inhibition
scavenging
suppressing
expression
NLRP3.
In
rat
model
transient
middle
artery
occlusion,
enhanced
behavioral
recovery
neuronal
repair
were
achieved
through
at
lesion
site
implementation
interventions
inhibit
pyroptosis,
thereby
demonstrating
effects.
Overall,
this
work
emphasizes
importance
cascade-regulated
reducing
neuroinflammation,
offering
important
mechanistic
understanding
possible
approaches
Язык: Английский
Integration of Photodiagnosis and Therapy Guided by Micro/Nanorobots
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 13, 2025
Micro/Nanorobots(MNRs)integrated
with
phototherapy
represent
an
emerging
approach
to
cancer
treatment
and
hold
significant
potential
for
addressing
bacterial
infections,
neurological
disorders,
cardiovascular
diseases,
related
conditions.
By
leveraging
micro/nanoscale
motor
systems
in
conjunction
phototherapy,
these
robots
enable
real-time
guidance
monitoring
of
therapeutic
processes,
improving
drug
delivery
precision
efficiency.
This
integration
not
only
enhances
the
effectiveness
but
also
minimizes
damage
surrounding
healthy
tissues.
Nevertheless,
clinical
translation
MNRs-assisted
still
faces
numerous
challenges.
In
this
review,
recent
key
developments
field
are
comprehensively
summarized,
critical
roles
applications
highlighted,
insights
into
future
directions
pathway
toward
large-scale
implementation
provided.
Язык: Английский
ROS-related nanoparticles for the management of Alzheimer’s disease: Wielding the double-edged sword
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 161784 - 161784
Опубликована: Март 1, 2025
Язык: Английский
Caffeic Acid–Biogenic Amine Complexes Outperform Standard Drugs in Reducing Toxicity: Insights from In Vivo Iron Chelation Studies
Molecular Pharmaceutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 2, 2025
Iron
homeostasis
imbalance,
caused
by
conditions
such
as
thalassemia,
sickle
cell
anemia,
and
myocardial
infarction,
often
results
in
elevated
free
iron
levels,
leading
to
ferroptosis
severe
organ
damage.
While
current
chelators
like
deferoxamine
(DFO)
deferiprone
are
effective,
they
associated
with
significant
side
effects,
including
nephrotoxicity,
gastrointestinal
bleeding,
liver
fibrosis.
This
creates
an
urgent
need
for
safer,
natural-product-based
alternatives
effective
chelation
therapy
(ICT).
study
investigates
caffeic
acid
(CA)-based
complexes
biogenic
amines,
specifically
spermine
(CA-Sp)
histidine
(CA-His),
potential
ICT
candidates.
Initial
vitro
assays
on
HEK-293
cells
under
dextran
(ID)-induced
toxicity
have
demonstrated
their
protective
CA-Sp
exhibiting
superior
efficacy.
The
vivo
studies
mice
further
validated
potential,
showing
remarkable
mitigation
compared
DFO.
Inductively
coupled
plasma
mass
spectrometry
(ICP-MS)
reveals
excretion
fecal
matter
the
treatment
group
along
reductions
serum
ferritin
levels.
markers
of
nephrotoxicity
(creatinine)
function
(ALT,
AST)
also
been
shown
be
normalized
treated
groups,
while
immunological
analyses
revealed
restored
levels
neutrophils,
T
cells,
B
cells.
Additionally,
inflammatory
cytokines,
TNF-α
IL-6,
exhibited
reductions,
CA-based
formulations
surpassing
effects
Histological
using
Prussian
blue
staining
confirmed
reduced
deposition
vital
organs
liver,
kidney,
spleen.
These
findings
highlight
a
particularly
promising
candidate
ICT,
offering
safer
more
strategy
managing
overload
its
complications.
Язык: Английский
Nanobiotechnologies for stroke treatment
Nanomedicine,
Год журнала:
2025,
Номер
unknown, С. 1 - 21
Опубликована: Май 6, 2025
Stroke
has
brought
about
a
poor
quality
of
life
for
patients
and
substantial
societal
burden
with
high
morbidity
mortality.
Thus,
the
efficient
stroke
treatment
always
been
hot
topic
in
research
medicine.
In
past
decades,
nanobiotechnologies,
including
natural
exosomes
artificial
nanomaterials,
have
focus
attention
due
to
their
inherent
advantages,
such
as
facile
blood
-
brain
barrier
traversal
drug
encapsulation
efficiency.
Recently,
thanks
rapid
development
more
efforts
made
study
therapeutic
effects
nanomaterials
well
relevant
mechanisms
treatment.
Herein,
from
recent
studies
articles,
application
are
summarized.
And
prospects
clinical
translation
future
also
discussed
further
detail.
Язык: Английский