A “CPApoptosis” nano-actuator switches immune-off solid tumors to immune-on for fueling T-cell- based immunotherapy
Theranostics,
Год журнала:
2025,
Номер
15(9), С. 3797 - 3820
Опубликована: Март 3, 2025
Background:
Most
anticancer
agents
induce
tumor
apoptosis,
but
they
often
lack
immunogenicity
and
display
limited
success
when
combined
with
mainstream
immunotherapies,
thus
killing
cancer
cells
through
multiple
cell
death
modalities
as
well
switching
immune-off
tumors
to
immune-on
is
a
strategy
great
promise.
To
this
end,
we
developed
CPApoptosis
(cuproptosis,
pyroptosis,
apoptosis)
nano-actuator
for
immunologically
cold
solid
tumors.
Methods:
In
study,
elesclomol
(ES),
mitochondrial
targeting
copper
transporter,
was
encapsulated
within
bacterial
outer
membrane
vesicles
(OMVs).
These
OMVs
were
then
surface-modified
via
metal-phenolic
self-assembly
using
Cu2+
tannic
acid
(TA).
Results:
The
ES
released
from
the
in
pH-dependent
manner.
OMV
activated
non-canonical
pyroptotic
pathway,
leading
rupture.
on
one
hand
transported
mitochondria
cuproptosis
facilitated
by
ES,
other
hand,
reduced
into
Cu+
TA,
which
catalyzed
ROS
production
oxidative
apoptosis.
Simultaneously,
TA
degraded
glutathione
(GSH),
sensitizing
cuproptosis.
multifactorial
mechanisms
led
release
of
immunogenic
factors
lysed
cells,
stimulating
dendritic
maturation
recruiting
cytotoxic
T
cells.
This
immune
response
further
amplified
αPD-L1
antibody
treatment.
Conclusion:
represents
promising
approach
enhance
current
therapies,
inducing
both
robust
response,
potential
long-lasting
protective
effects.
Язык: Английский
Ultrasound-mediated nanomaterials for the treatment of inflammatory diseases
Ultrasonics Sonochemistry,
Год журнала:
2025,
Номер
114, С. 107270 - 107270
Опубликована: Фев. 13, 2025
Sterile
and
infection-associated
inflammatory
diseases
are
becoming
increasingly
prevalent
worldwide.
Conventional
drug
therapies
often
entail
significant
drawbacks,
such
as
the
risk
of
overdose,
development
resistance
in
pathogens,
systemic
adverse
reactions,
all
which
can
undermine
effectiveness
treatments
for
these
conditions.
Nanomaterials
(NMs)
have
emerged
a
promising
tool
treatment
due
to
their
precise
targeting
capabilities,
tunable
characteristics,
responsiveness
external
stimuli.
Ultrasound
(US),
non-invasive
effective
method,
has
been
explored
combination
with
NMs
achieve
enhanced
therapeutic
outcomes.
This
review
provides
comprehensive
overview
recent
advances
use
US-mediated
treating
diseases.
A
introduction
application
classification
US
was
first
presented,
emphasizing
advantages
mechanisms
through
interact
enhance
anti-inflammatory
therapy.
Subsequently,
specific
applications
sterile
inflammation
were
summarized.
Finally,
challenges
prospects
clinical
translation
discussed,
along
an
outline
future
research
directions.
aims
provide
insights
guide
improvement
more
interventions
Язык: Английский
Non-central symmetric 2D bismuth‐based perovskites for piezoelectric-enhanced sonodynamic immunotherapy
Journal of Colloid and Interface Science,
Год журнала:
2025,
Номер
687, С. 386 - 401
Опубликована: Фев. 13, 2025
Язык: Английский
Ruthenium-doped carbon dots with “three-in-one” chemodynamic, photodynamic, and photothermal activity induce panoptosis for tumor therapy
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 161355 - 161355
Опубликована: Март 1, 2025
Язык: Английский
Unravelling the Role of PANoptosis in Liver Diseases: Mechanisms and Therapeutic Implications
Liver International,
Год журнала:
2025,
Номер
45(4)
Опубликована: Март 21, 2025
PANoptosis
is
a
multimodal
form
of
cell
death
that
involves
inflammatory,
apoptotic,
and
necroptotic
pathways,
playing
key
role
in
the
development
liver
diseases.
This
article
first
outlines
definition
characteristics
PANoptosis,
then
explores
its
mechanisms
action
different
types
diseases,
including
acute
injury,
failure,
metabolic
dysfunction-associated
fatty
disease,
hepatocellular
carcinoma.
Furthermore,
this
analyses
molecular
regulatory
network
potential
therapeutic
targets.
Finally,
summarises
current
research
on
diseases
future
directions,
it
reviews
emerging
mechanism
Язык: Английский
Polydopamine-Encapsulated Cyanine Dye Nanoplatform for Near-Infrared Fluorescence Imaging-Guided Photothermal Therapy of Hepatocellular Carcinoma
ACS Applied Polymer Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 10, 2025
Язык: Английский
Nanomaterials in the diagnosis and treatment of gastrointestinal tumors: New clinical choices and treatment strategies
Materials Today Bio,
Год журнала:
2025,
Номер
unknown, С. 101782 - 101782
Опубликована: Апрель 1, 2025
Язык: Английский
Nanomaterials‐Induced PANoptosis: A Promising Anti‐Tumor Strategy
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 19, 2024
Abstract
Malignant
tumors
pose
a
significant
threat
to
global
public
health.
Promoting
programmed
cell
death
in
cancer
cells
has
become
critical
strategy
for
treatment.
PANoptosis,
newly
discovered
form
of
regulated
death,
integrates
key
molecular
components
pyroptosis,
apoptosis,
and
necroptosis,
activating
these
three
pathways
simultaneously
achieve
synergistic
multi‐mechanistic
killing.
PANoptosis
significantly
inhibits
growth
resistance
activates
strong
anti‐tumor
immune
response,
making
tumor‐specific
induction
potential
therapeutic
strategy.
Currently,
treatment
research
related
is
focused
mainly
on
the
development
small
molecules
cytokines.
However,
approaches
still
face
limitations
terms
metabolic
stability
tumor
specificity.
The
unique
physicochemical
properties
biological
activities
nanomaterials
hold
promise
optimizing
strategies.
This
review
summarizes
concept
mechanisms
highlights
latest
applications
nanoagents
PANoptosis‐based
anti‐cancer
therapy,
discusses
challenges
future
directions
clinical
translation.
It
hoped
that
this
will
inspire
further
exploration
treatments,
providing
new
perspectives
researchers
field.
Язык: Английский
Nanomaterials‐Induced PANoptosis: A Promising Anti‐Tumor Strategy
Angewandte Chemie,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 19, 2024
Abstract
Malignant
tumors
pose
a
significant
threat
to
global
public
health.
Promoting
programmed
cell
death
in
cancer
cells
has
become
critical
strategy
for
treatment.
PANoptosis,
newly
discovered
form
of
regulated
death,
integrates
key
molecular
components
pyroptosis,
apoptosis,
and
necroptosis,
activating
these
three
pathways
simultaneously
achieve
synergistic
multi‐mechanistic
killing.
PANoptosis
significantly
inhibits
growth
resistance
activates
strong
anti‐tumor
immune
response,
making
tumor‐specific
induction
potential
therapeutic
strategy.
Currently,
treatment
research
related
is
focused
mainly
on
the
development
small
molecules
cytokines.
However,
approaches
still
face
limitations
terms
metabolic
stability
tumor
specificity.
The
unique
physicochemical
properties
biological
activities
nanomaterials
hold
promise
optimizing
strategies.
This
review
summarizes
concept
mechanisms
highlights
latest
applications
nanoagents
PANoptosis‐based
anti‐cancer
therapy,
discusses
challenges
future
directions
clinical
translation.
It
hoped
that
this
will
inspire
further
exploration
treatments,
providing
new
perspectives
researchers
field.
Язык: Английский
Synergistic effects of repeated transcranial magnetic stimulation and mesenchymal stem cells transplantation on alleviating neuroinflammation and PANoptosis in cerebral ischemia
Journal of Neuroinflammation,
Год журнала:
2024,
Номер
21(1)
Опубликована: Ноя. 30, 2024
Neuronal
death
is
the
primary
cause
of
poor
outcomes
in
cerebral
ischemia.
The
inflammatory
infiltration
early
phase
ischemic
stroke
plays
a
vital
role
triggering
neuronal
death.
Either
transplantation
mesenchymal
stem
cells
(MSCs)
derived
from
humans
or
repetitive
transcranial
magnetic
stimulation
(rTMS)
have
respectively
proved
to
be
neuroprotective
and
anti-inflammatory
However,
either
treatment
above
has
its
limitations.
Whether
these
two
therapies
synergistic
effects
on
improving
neurological
function
underlying
mechanisms
remains
unclear.
This
investigation
aims
elucidate
MSCs
combined
with
rTMS
recovery
post-ischemia.
A
Sprague-Dawley
rat
model
infarction
was
induced
via
transient
middle
artery
occlusion
(tMCAO).
rats
were
divided
into
five
groups
(n
=
50):
sham,
tMCAO,
rTMS,
MSCs,
+
groups.
Transplantation
human
umbilical
cord
intervention
performed
24
h
post-stroke.
Neurological
further
assessed
several
behavioral
tests
2,3,5-triphenyltetrazolium
chloride
(TTC)
staining
companied
Nissl
used
assess
survival.
TUNEL
staining,
western
blotting,
immunofluorescence,
immunohistochemistry,
ELISA,
flow
cytometry
employed
measure
levels
neuroinflammation
PANoptosis.
molecular
special
therapy
distinguished
transcriptome
sequencing
PC12
oxygen-glucose
deprivation/reoxygenation
(OGD/R)
conditions.
efficiently
reduced
lesion
volume
improved
survival
(P
<
0.05),
subsequently
functional
after
stroke.
ameliorated
PANoptosis
neurons
accompanied
by
decreased
factors
tissue
serum
during
subacute
infarction.
To
explore
roles
effect,
we
found
that
transplanted
primarily
localized
spleen
ischemia
suppressed
splenic
inflammation.
Meanwhile,
significantly
protects
MSCs-inhibited
conditions
downregulating
REST
unveiled
sequencing.
Our
study
elucidates
an
unidentified
mechanism
which
combination
could
synergistically
promote
suppress
infarction,
thus
outcomes.
may
potentially
contribute
effect
against
These
results
are
expected
provide
novel
insights
protecting
injury
potential
targets
Язык: Английский