Chemiluminescent transition metal complexes: Mechanisms and applications

Coordination Chemistry Reviews, Год журнала: 2025, Номер 530, С. 216495 - 216495

Опубликована: Фев. 5, 2025

Язык: Английский

---

A Dual‐Targeting Biomimetic Nanoplatform Integrates SDT/CDT/Gas Therapy to Boost Synergistic Ferroptosis for Orthotopic Hepatocellular Carcinoma Therapy

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Abstract The development of efficient therapeutic strategies to promote ferroptotic cell death offers significant potential for hepatocellular carcinoma (HCC) treatment. Herein, this study presents an HCC‐targeted nanoplatform that integrates bimetallic FeMoO 4 nanoparticles with CO‐releasing molecules, and further camouflaged SP94 peptide‐modified macrophage membrane enhanced ferroptosis‐driven multi‐modal therapy HCC. Leveraging the multi‐enzyme activities multivalent metallic elements, not only decomposes H 2 O generate oxygen alleviate tumor hypoxia but also depletes glutathione inactivate peroxides 4, which amplify sonodynamic under ultrasound (US) irradiation. Meanwhile, catalyzes Fenton reaction produce hydroxyl radicals chemodynamic therapy. Elevated intracellular reactive species trigger cascade release CO, leading lethal lipid peroxidation enhancing ferroptosis‐mediated This demonstrates robust anti‐tumor efficacy US irradiation favorable biosafety in both subcutaneous orthotopic HCC models, representing a promising approach Additionally, findings offer new insights into microenvironment modulation optimize US‐triggered cancer

Язык: Английский

---

Biomaterials for Modulating the Immune Microenvironment in Rheumatoid Arthritis

BME Frontiers, Год журнала: 2025, Номер 6

Опубликована: Янв. 1, 2025

Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease characterized by joint swelling and bone destruction. Despite an incomplete understanding of its genesis, RA tightly linked to the intricate immunological milieu, involving disruptions in molecular signaling imbalance between innate adaptive immune systems. With advancements biomaterials science, role treatment has evolved from mere drug delivery systems therapeutic microenvironment modulators, providing drug-independent strategies for RA. In this review, we will delve into RA, focusing on contributions immunity, damage-associated patterns (DAMPs), cytokines, pathways disease’s pathogenesis inflammation. We provide detailed analysis applications novel nonpharmaceutical treatment, categorized 3 key mechanisms: biofactor pathway regulation, endogenous gas adjustment, cell modulation. The composition, form, principles, efficacy these be explored. thorough discussion topics offer fresh viewpoint guide future research directions.

Язык: Английский

---

Eliminating the solvent-induced distortions of the NIR-II fluorescent probe spectroscopy via deuterated solvents

Science China Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 6, 2025

Язык: Английский

---

Dendritic donor engineering to optimize second near-infrared photothermal agents for in situ photothermal therapy

Journal of Colloid and Interface Science, Год журнала: 2025, Номер 689, С. 137190 - 137190

Опубликована: Март 7, 2025

Язык: Английский

---

Dynamic Pathophysiological Insight into the Brain by NIR‐II Imaging

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

Cerebral collateral circulation and blood-brain barrier (BBB) are critically required to maintain the normal brain functions, a fact stressing need for accurate in vivo diagnostic tools that can afford valuable pathophysiological insight into functioning of neurovascular unit space time. Currently, understanding perfusion BBB evolution under both physiological pathological conditions remains sparse, largely owing limitations methods recording diminutive route cerebral blood flow. Here, it is reported highly crystalline semiconducting organic nanoprobes (named 4T-BSA) composed small-molecule dye bovine serum albumin showed vast potential live-brain vascular imaging second near-infrared window (NIR-II, 1000-1700 nm). The 4T-BSA had superior penetration depth intact mouse with high signal-to-background ratio (SBR) 6.0 down sub-50-µm spatial resolution vasculature three typical models neurological pathophysiology. By visualizing leakage, identified activities associated arterial/venous flow network disruption. It anticipated NIR-II disruption will bring broad opportunities address major medical challenges across timely, protective, restorative interventions diseases.

Язык: Английский

---

A cyanine fluorophore for imaging-guided tumor photodynamic and photothermal therapy under NIR-II light activation

Science China Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

Язык: Английский

---

Supramolecular Self‐assembled Endoplasmic Reticulum‐Targeted Peptide Synergistically Triggers Type II ICD via Cascade Generation of Endogenous ROS and RNS for Cancer Immunotherapy

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 9, 2025

Abstract Endoplasmic reticulum (ER) stress triggered by reactive oxygen species (ROS) generated through photodynamic therapy emerges as an effective strategy for inducing immunogenic cell death (ICD). However, its therapeutic potential is often constrained hypoxia and elevated glutathione levels in the tumor. Here, a novel ER‐targeted self‐assembled chimeric peptide, OTBS‐FR‐ER, which synergistically induces type II ICD via cascade generation of ROS nitrogen (RNS) at ER site presented. The peptide contains aggregation‐induced emission (AIE) photosensitizer (OTBS), β‐amyloid‐inspired self‐assembly motif (FFVLK), oligo‐arginine nitric oxide (NO) donor (RRRR), ER‐targeting signal (KDEL), self‐assembles to form nanofibers situ after targeting generates induce response photo‐irradiation. Simultaneously, ROS‐driven NO subsequent formation peroxynitrite anion (ONOO⁻) further amplify stress. In prostate cancer models, OTBS‐FR‐ER effectively converts “cold” tumors into “hot” tumors, significantly activating body's anti‐tumor immunity. Comprehensive vitro vivo studies highlight superior tumor inhibition immune activation capabilities. This work provides designing photo‐controlled inducers, offering promising direction overcome limitations conventional immunotherapies.

Язык: Английский

---

Fluorescent probes in autoimmune disease research: current status and future prospects

Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)

Опубликована: Апрель 9, 2025

Autoimmune diseases (AD) present substantial challenges for early diagnosis and precise treatment due to their intricate pathogenesis varied clinical manifestations. While existing diagnostic methods strategies have advanced, sensitivity, specificity, real-time applicability in settings continue exhibit significant limitations. In recent years, fluorescent probes emerged as highly sensitive specific biological imaging tools, demonstrating potential AD research.This review examines the response mechanisms historical evolution of various types probes, systematically summarizing latest research advancements application autoimmune diseases. It highlights key applications biomarker detection, dynamic monitoring immune cell functions, assessment drug efficacy. Furthermore, this article analyzes technical currently encountered probe development proposes directions future research. With ongoing materials science, nanotechnology, bioengineering, are anticipated achieve higher sensitivity enhanced functional integration, thereby facilitating monitoring, innovative Overall, possess scientific significance value both related diseases, signaling a new era personalized precision medicine.

Язык: Английский

---

Biomimetic Nanoplatform for Targeted Rheumatoid Arthritis Therapy: Modulating Macrophage Niches Through Self‐Sustaining Positive Feedback‐Driven Drug Release Mechanisms

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 22, 2025

Abstract The core strategies in treating rheumatoid arthritis (RA) now focus on ameliorating the inflammatory microenvironment and reversing macrophage phenotypes within joint cavity. This study introduces a co‐delivery system of integrating nanoenzymes gene therapeutics sequentially modified with guanidinium‐based polymers membranes to achieve synergistic therapeutic effects. is named MACP siTNF‐α nanoparticles (NPs). are designed for targeted delivery inflamed site, where they preferentially internalized by M1‐type macrophages efficiently evade lysosomal degradation. Subsequently, operates via self‐sustaining positive feedback drug release mechanism. biomimetic nanoplatform reduces reactive oxygen species (ROS) levels prevents glutathione (GSH) depletion. GSH degrades small interfering RNA (siRNA) expose Prussian blue (PB) nanoenzymes, which effectively scavenge ROS restore levels. loop significantly enhances silencing capability scavenging efficiency system. In summary, NPs can reverse ecological niche soils through dual mechanism inhibiting expression tumor necrosis factor‐alpha (TNF‐α) upstream pathway response, eliminating ROS, thus realizing efficient treatment RA.

Язык: Английский

---