Advances in Multimodal Synergistic Therapy Derived from Sonodynamic Therapy Mediated by BaTiO3 Piezoelectric Nanomaterials in Tumor Treatment
Small Structures,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 5, 2025
Tumors
endanger
the
lives
of
individuals
worldwide.
They
form
and
metastatize
to
nearby
distant
tissues
organs
in
several
ways,
which
greatly
increase
difficulty
therapy.
The
continuous
development
progress
nanomedicine
has
provided
new
insights
treatment
tumors.
Owing
their
excellent
properties
barium
titanate
(BaTiO
3
,
BTO),
especially
piezoelectricity,
BTO‐based
nanomaterials
have
become
popular
among
tumor
therapy
researchers
recent
years.
sonodynamic
(SDT)
is
considerably
advanced
than
traditional
therapies.
Herein,
first,
properties,
structure,
preparation
technology,
working
mechanism
BTO
under
ultrasonic
stimulation
systematically
introduced.
Second,
research
BTO‐mediated
SDT,
electrical
therapy,
SDT‐derived
multimodal
synergistic
field
reviewed.
Third,
biocompatibility,
biodistribution,
bioelimination
summarized.
Finally,
current
problems
associated
with
SDT
as
well
potential
obstacles
opportunities
oncology
other
biomedical
fields
are
summarized
prospected.
Язык: Английский
Charge separation engineering modulates self-oxygenating nano-heterojunctions to induce ferroptosis for sonodynamic-immunotherapy of tumors
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 160713 - 160713
Опубликована: Фев. 1, 2025
Язык: Английский
Editing Benzotrithiophene-Based Covalent Organic Frameworks for Developing New Sonosensitizers
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 2, 2025
Recent
insights
into
covalent
organic
frameworks
(COFs)
provide
an
opportunity
for
developing
new
sonosensitizers
with
the
advantages
of
both
small
molecules
and
inorganic
nanoagents.
Herein,
we
synthesize
two
benzotrithiophene-based
imine-linked
COFs
(BTT-DPh-COF
BTT-DPy-COF)
through
density-functional-theory-guided
structure
editing.
The
tailored
donor-acceptor
(D-A)
structures
optimize
band
position
endow
them
good
intrinsic
sonodynamic
activity,
which
can
efficiently
kill
cancer
cells,
showing
excellent
therapeutic
effect.
Particularly,
because
enhanced
D-A
effect
that
promotes
charge
separation
transfer
behavior,
BTT-DPy-COF
exhibits
superior
ultrasound-triggered
reactive
oxygen
species
(ROS)
generation
capability
than
BTT-DPh-COF.
Therefore,
these
studies
highlight
great
potential
elaborate
editing
configurations
as
suitable
candidates
advanced
sonosensitizers.
Язык: Английский
Aptamer-Modified Mesoporous Silica Nanoparticle for Nitric Oxide-Enhanced Targeted Sonodynamic Therapy against Lung Cancer
ACS Applied Nano Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 3, 2025
The
challenging
treatment
outcomes
for
nonsmall
cell
lung
cancer
(NSCLC)
necessitate
the
development
of
innovative
therapeutic
strategies.
In
this
work,
we
developed
a
multifunctional
nanoplatform
by
modifying
mesoporous
silica
nanoparticles
(MSNs)
with
an
aptamer
(Apt)
targeting
epidermal
growth
factor
(EFGR),
and
coloading
sonosensitizer,
hematoporphyrin
(HP),
along
natural
nitric
oxide
(NO)
donor,
l-arginine
(l-Arg).
resulting
Apt-modified
MSN
loaded
l-Arg
HP
(designated
as
AMLH)
was
designed
targeted
gas-assisted
sonodynamic
therapy
(SDT)
NSCLC.
AMLH
exhibited
appropriate
particle
size,
good
drug
loading
ability,
ultrasound-responsive
release.
resulted
in
higher
encapsulation
efficiency
compared
to
single-drug
loading,
remained
stable
when
stored
at
4
°C
15
days.
capable
generating
reactive
oxygen
species
(ROS)
NO
under
ultrasound
stimulation,
leading
further
production
peroxynitrite
(ONOO–).
demonstrated
specific
recognition
EGFR-positive
NSCLC
cells,
preincubation
free
Apt
reducing
cellular
uptake,
confirming
specificity
Apt-functionalized
nanoparticles.
Cellular
distribution
studies
revealed
that
primarily
localized
lysosomes
after
internalization.
MTT
assays
live/dead
staining
confirmed
superior
cytotoxicity
AMLH,
which
effectively
inhibits
proliferation
through
mitochondrial
membrane
potential
collapse
nuclear
damage
stimulation.
These
results
highlight
combined
efficacy
EGFR
targeting,
SDT,
gas
therapy,
offering
promising
strategy
improve
outcomes.
Язык: Английский
A nanocatalytic membrane with sono-responsive antibacterial therapy (SRAT) for rapid sterilization and enhanced chronic wound healing
Nanoscale,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
A
novel
PN-bioHJ
membrane
combining
black
phosphorus
and
barium
titanate
on
a
PLGA
platform
achieves
>99%
antibacterial
efficiency
under
ultrasound,
with
excellent
biocompatibility
for
infected
tissue
regeneration.
Язык: Английский
Membrane‐Anchoring and Oxygen‐Generating Mediated Nanosonosensitizer for Optimizing Cancer Immunotherapy
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 24, 2025
Despite
its
antitumor
promise,
sonodynamic
therapy
(SDT)'s
efficacy
in
immune
activation
requires
enhancement,
primarily
due
to
the
hypoxic
tumor
microenvironment
(TME)
and
insufficient
targeting
of
sonosensitizers
specific
subcellular
regions.
Herein,
we
developed
macrophage
membrane
(MM)-intermingled
fusogenic
liposomes
(MFL)
optimize
sonoimmunotherapy
that
encapsulate
catalase
(CAT)
within
core
incorporate
sonosensitizer
chlorin
e6
(Ce6)
outer
shell
(CAT@MM-MFL-Ce6).
The
MM
confers
evasion
properties
promotes
nanoparticles'
targeted
accumulation
tissue.
fusion
effect
enables
Ce6
anchor
onto
cancer
cell
facilitates
direct
delivery
CAT
into
cytoplasm,
bypassing
endosomal
degradation.
Upon
ultrasound
stimulation,
generated
reactive
oxygen
species
directly
damage
plasma
membrane,
initiating
Caspase
3/Gasdermin
E-mediated
pyroptosis
pathway.
Concurrently,
encapsulated
efficiently
decompose
H₂O₂
thus
enhancing
local
levels
tumors.
Contributed
by
these
effects,
combination
nanosonosensitizer-augmented
SDT
checkpoint
agent
successfully
reverse
immunosuppressive
TME,
driving
a
potent
response
inhibits
primary
growth,
distant
metastasis,
lung
metastases
an
orthotopic
triple-negative
breast
model.
This
study
demonstrates
potential
novel
SDT-based
combinatorial
approach
modulate
immune-cold
TMEs,
advancing
proof-of-concept
therapeutics.
Язык: Английский
Piezoelectric Iridium-Doped Bismuth Ferrite/Sodium Alginate Hydrogel for Antibiosis and Stimulating Osteoblastic Differentiation
Lei Sun,
Weijie Yang,
Shangyu Xie
и другие.
ACS Applied Nano Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
Язык: Английский
Ultrasound‐Propelled Nanomotors Enable Activatable Near‐Infrared‐II Fluorescence Imaging‐Guided Synergistic Oxygen‐Independent and Oxygen‐Dependent Sonodynamic Therapy of Atherosclerosis
Zeyu Jiang,
Chuang Wei,
Shanglang Cai
и другие.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 28, 2025
Abstract
Sonodynamic
therapy
(SDT)
holds
great
promise
as
a
therapeutic
approach
for
treating
atherosclerotic
plaque.
However,
the
efficacy
of
SDT
is
hindered
by
restricted
tissue
penetration
depth
and
insufficient
generation
reactive
oxygen
species
(ROS)
associated
with
conventional
sonosensitizers.
Furthermore,
determining
optimal
timing
ultrasound
(US)
irradiation
after
administration
sonosensitizers
presents
significant
technical
challenge.
Addressing
these
issues
crucial
enhancing
effectiveness
SDT.
Herein,
hyaluronic
acid‐modified
US‐propelled
Janus
mesoporous
SiO
2
partially
coated
gold
nanorods
loaded
2,2‐azobis[2‐(2‐imidazolin‐2‐yl)
propane]
dihydrochloride
(AIPH)
developed,
along
functionalized
Ag/Ag
S
nanoparticles
(HA‐JASAA),
near‐infrared‐II
(NIR‐II)
fluorescence
imaging‐guided
Following
intravenous
HA‐JASAA,
acid
modification
enables
specific
targeting
proinflammatory
macrophages
within
plaques.
Subsequently,
upon
reacting
H
O
in
microenvironment,
it
turns
on
NIR‐II
signal.
US
applied
when
intensity
signal
reaches
its
peak;
AIPH
HA‐JASAA
undergoes
conversion
into
nitrogen
propelling
toward
deep
plaque
tissue.
under
activation,
two
sonosensitizers,
Ag
S,
generate
oxygen‐independent
oxygen‐dependent
ROS
respectively
to
induce
apoptosis
lesional
macrophages,
thereby
significantly
inhibiting
progression
Язык: Английский