Biomaterials, Год журнала: 2025, Номер unknown, С. 123450 - 123450
Опубликована: Май 1, 2025
Язык: Английский
Advanced Science, Год журнала: 2025, Номер unknown
Опубликована: Апрель 25, 2025
Abstract Sonodynamic therapy (SDT) has emerged as a promising noninvasive approach for tumor therapy. However, the effectiveness of traditional inorganic semiconductor sonosensitizers is hindered by rapid electron (e − ) and hole (h + recombination under ultrasonic (US) stimulation, well hypoxic reductive conditions microenvironment (TME), which limit generation reactive oxygen species (ROS). Herein, ruthenium (Ru) single‐atom nanozyme‐driven superimposition‐enhanced titanium dioxide‐based sonosensitizer (Ru/TiO 2‐x SAE) presented that features sufficient vacancies high e /h separation efficiency. Through synchrotron radiation‐based X‐ray absorption spectroscopy extended fine structure analysis it confirmed in TiO nanoparticles promote immobilization single‐atomic Ru, forming Ru‐O₄ active sites. Density functional theory calculations demonstrate alter electronic nanosensitizer, enhanced separation, increasing adsorption, accelerating reaction kinetics US ultimately improving ROS production. Moreover, Ru/TiO SAE boosts sonodynamic efficacy mitigating TME. This attributed to its catalase‐ glutathione peroxidase 4‐like activities, facilitate trigger lipid peroxidation‐mediated ferroptosis. These findings highlight innovative role Ru optimizing SDT‐induced ferroptosis, demonstrating potential advancing cancer
Язык: Английский
Процитировано
1
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Март 2, 2025
Recent insights into covalent organic frameworks (COFs) provide an opportunity for developing new sonosensitizers with the advantages of both small molecules and inorganic nanoagents. Herein, we synthesize two benzotrithiophene-based imine-linked COFs (BTT-DPh-COF BTT-DPy-COF) through density-functional-theory-guided structure editing. The tailored donor-acceptor (D-A) structures optimize band position endow them good intrinsic sonodynamic activity, which can efficiently kill cancer cells, showing excellent therapeutic effect. Particularly, because enhanced D-A effect that promotes charge separation transfer behavior, BTT-DPy-COF exhibits superior ultrasound-triggered reactive oxygen species (ROS) generation capability than BTT-DPh-COF. Therefore, these studies highlight great potential elaborate editing configurations as suitable candidates advanced sonosensitizers.
Язык: Английский
Процитировано
1
ACS Applied Nano Materials, Год журнала: 2025, Номер unknown
Опубликована: Март 3, 2025
The challenging treatment outcomes for nonsmall cell lung cancer (NSCLC) necessitate the development of innovative therapeutic strategies. In this work, we developed a multifunctional nanoplatform by modifying mesoporous silica nanoparticles (MSNs) with an aptamer (Apt) targeting epidermal growth factor (EFGR), and coloading sonosensitizer, hematoporphyrin (HP), along natural nitric oxide (NO) donor, l-arginine (l-Arg). resulting Apt-modified MSN loaded l-Arg HP (designated as AMLH) was designed targeted gas-assisted sonodynamic therapy (SDT) NSCLC. AMLH exhibited appropriate particle size, good drug loading ability, ultrasound-responsive release. resulted in higher encapsulation efficiency compared to single-drug loading, remained stable when stored at 4 °C 15 days. capable generating reactive oxygen species (ROS) NO under ultrasound stimulation, leading further production peroxynitrite (ONOO–). demonstrated specific recognition EGFR-positive NSCLC cells, preincubation free Apt reducing cellular uptake, confirming specificity Apt-functionalized nanoparticles. Cellular distribution studies revealed that primarily localized lysosomes after internalization. MTT assays live/dead staining confirmed superior cytotoxicity AMLH, which effectively inhibits proliferation through mitochondrial membrane potential collapse nuclear damage stimulation. These results highlight combined efficacy EGFR targeting, SDT, gas therapy, offering promising strategy improve outcomes.
Язык: Английский
Процитировано
1
Small Structures, Год журнала: 2025, Номер unknown
Опубликована: Фев. 5, 2025
Tumors endanger the lives of individuals worldwide. They form and metastatize to nearby distant tissues organs in several ways, which greatly increase difficulty therapy. The continuous development progress nanomedicine has provided new insights treatment tumors. Owing their excellent properties barium titanate (BaTiO 3 , BTO), especially piezoelectricity, BTO‐based nanomaterials have become popular among tumor therapy researchers recent years. sonodynamic (SDT) is considerably advanced than traditional therapies. Herein, first, properties, structure, preparation technology, working mechanism BTO under ultrasonic stimulation systematically introduced. Second, research BTO‐mediated SDT, electrical therapy, SDT‐derived multimodal synergistic field reviewed. Third, biocompatibility, biodistribution, bioelimination summarized. Finally, current problems associated with SDT as well potential obstacles opportunities oncology other biomedical fields are summarized prospected.
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160713 - 160713
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Nanoscale, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
A novel PN-bioHJ membrane combining black phosphorus and barium titanate on a PLGA platform achieves >99% antibacterial efficiency under ultrasound, with excellent biocompatibility for infected tissue regeneration.
Язык: Английский
Процитировано
0
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Март 24, 2025
Despite its antitumor promise, sonodynamic therapy (SDT)'s efficacy in immune activation requires enhancement, primarily due to the hypoxic tumor microenvironment (TME) and insufficient targeting of sonosensitizers specific subcellular regions. Herein, we developed macrophage membrane (MM)-intermingled fusogenic liposomes (MFL) optimize sonoimmunotherapy that encapsulate catalase (CAT) within core incorporate sonosensitizer chlorin e6 (Ce6) outer shell (CAT@MM-MFL-Ce6). The MM confers evasion properties promotes nanoparticles' targeted accumulation tissue. fusion effect enables Ce6 anchor onto cancer cell facilitates direct delivery CAT into cytoplasm, bypassing endosomal degradation. Upon ultrasound stimulation, generated reactive oxygen species directly damage plasma membrane, initiating Caspase 3/Gasdermin E-mediated pyroptosis pathway. Concurrently, encapsulated efficiently decompose H₂O₂ thus enhancing local levels tumors. Contributed by these effects, combination nanosonosensitizer-augmented SDT checkpoint agent successfully reverse immunosuppressive TME, driving a potent response inhibits primary growth, distant metastasis, lung metastases an orthotopic triple-negative breast model. This study demonstrates potential novel SDT-based combinatorial approach modulate immune-cold TMEs, advancing proof-of-concept therapeutics.
Язык: Английский
Процитировано
0
ACS Applied Nano Materials, Год журнала: 2025, Номер unknown
Опубликована: Март 26, 2025
Язык: Английский
Процитировано
0
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Март 28, 2025
Abstract Sonodynamic therapy (SDT) holds great promise as a therapeutic approach for treating atherosclerotic plaque. However, the efficacy of SDT is hindered by restricted tissue penetration depth and insufficient generation reactive oxygen species (ROS) associated with conventional sonosensitizers. Furthermore, determining optimal timing ultrasound (US) irradiation after administration sonosensitizers presents significant technical challenge. Addressing these issues crucial enhancing effectiveness SDT. Herein, hyaluronic acid‐modified US‐propelled Janus mesoporous SiO 2 partially coated gold nanorods loaded 2,2‐azobis[2‐(2‐imidazolin‐2‐yl) propane] dihydrochloride (AIPH) developed, along functionalized Ag/Ag S nanoparticles (HA‐JASAA), near‐infrared‐II (NIR‐II) fluorescence imaging‐guided Following intravenous HA‐JASAA, acid modification enables specific targeting proinflammatory macrophages within plaques. Subsequently, upon reacting H O in microenvironment, it turns on NIR‐II signal. US applied when intensity signal reaches its peak; AIPH HA‐JASAA undergoes conversion into nitrogen propelling toward deep plaque tissue. under activation, two sonosensitizers, Ag S, generate oxygen‐independent oxygen‐dependent ROS respectively to induce apoptosis lesional macrophages, thereby significantly inhibiting progression
Язык: Английский
Процитировано
0
Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Sonodynamic therapy (SDT), characterized by its non-invasiveness, low toxicity, and deep tissue penetration, has emerged as a promising therapeutic modality for anticancer treatments. Recently, covalent organic frameworks (COFs) have garnered significant attention in the SDT realm powerful versatile toolbox. Notably, COF-based achieved many encouraging outcomes owing to remarkable potential of COFs, volume related research experienced continuous growth. Therefore, we strive provide timely comprehensive review that thoroughly summarizes advancements SDT. This begins with concise yet summary ultrasonic cavitation sonodynamic effects, elucidating fundamental principles mechanisms Subsequently, it delves into chemistry examining intricate structure designs, various types linkages, diverse synthetic methods. The primary focus this is summarize sonosensitizers, including construction strategies product properties. More importantly, role COFs combined therapies described detail, aiming highlight advantages COF-enhanced synergistic Finally, points out current challenges future opportunities rapidly evolving field. Overall, deliberations overviews sonosensitizers are expected facilitate advancements, leading early-stage clinical benefits patients.
Язык: Английский
Процитировано
0