Antitumor Research Based on Drug Delivery Carriers: Reversing the Polarization of Tumor-Associated Macrophages
Molecular Pharmaceutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 27, 2025
The
development
of
malignant
tumors
is
a
complex
process
that
involves
the
tumor
microenvironment
(TME).
An
immunosuppressive
TME
presents
significant
challenges
to
current
cancer
therapies,
serving
as
key
mechanism
through
which
cells
evade
immune
detection
and
play
crucial
role
in
progression
metastasis.
This
impedes
optimal
effectiveness
immunotherapeutic
approaches,
including
cytokines,
checkpoint
inhibitors,
vaccines.
Tumor-associated
macrophages
(TAMs),
major
component
tumor-infiltrating
cells,
exhibit
dual
functionalities:
M1-like
TAMs
suppress
tumorigenesis,
while
M2-like
promote
growth
Consequently,
various
nanocarriers
aimed
at
polarizing
phenotypes
distinct
mechanisms
has
emerged
promising
therapeutic
strategy
inhibit
escape
enhance
antitumor
responses.
Review
covers
origin
types
TAMs,
common
pathways
regulating
macrophage
polarization,
progression,
strategies
targeting
aiming
provide
comprehensive
understanding
guidance
for
future
research
clinical
applications.
Язык: Английский
Immune cell targeting-mediated cytomimetic drug delivery system for BBB-penetrating and precise therapy of in situ glioma
Materials Today Bio,
Год журнала:
2025,
Номер
unknown, С. 101694 - 101694
Опубликована: Март 1, 2025
Язык: Английский
PD-L1/PD-1 checkpoint pathway regulates astrocyte morphogenesis and myelination during brain development
Molecular Psychiatry,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 31, 2025
Язык: Английский
Combating cancer immunotherapy resistance: a nano‐medicine perspective
Cancer Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 10, 2025
Abstract
Cancer
immunotherapy
offers
renewed
hope
for
treating
this
disease.
However,
cancer
cells
possess
inherent
mechanisms
that
enable
them
to
circumvent
each
stage
of
the
immune
cycle,
thereby
evading
anti‐cancer
immunity
and
leading
resistance.
Various
functionalized
nanoparticles
(NPs),
modified
with
cationic
lipids,
pH‐sensitive
compounds,
or
photosensitizers,
exhibit
unique
physicochemical
properties
facilitate
targeted
delivery
therapeutic
agents
tumor
microenvironment
(TME).
These
NPs
are
engineered
modify
activity.
The
crucial
signal
transduction
pathways
by
which
counteract
resistance
outlined,
including
enhancing
antigen
presentation,
boosting
activation
infiltration
tumor‐specific
cells,
inducing
immunogenic
cell
death,
counteracting
immunosuppressive
conditions
in
TME.
Additionally,
review
summarizes
current
clinical
trials
involving
NP‐based
immunotherapy.
Ultimately,
it
highlights
potential
nanotechnology
advance
Язык: Английский