Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 157911 - 157911
Опубликована: Ноя. 1, 2024
Язык: Английский
Cell Reports Physical Science, Год журнала: 2025, Номер unknown, С. 102452 - 102452
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161104 - 161104
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Science Advances, Год журнала: 2025, Номер 11(11)
Опубликована: Март 14, 2025
Specific bacteria, including Fusobacterium nucleatum , Streptococcus sanguis Enterococcus faecalis and Staphylococcus xylosus have been identified as contributors to breast cancer metastasis. Due limitations such lack of selectivity, traditional antibiotic therapies face obstacles in eliminating intratumoral bacteria. Herein, this work proposes the use therapeutic vaccines selectively target eliminate harmful bacteria within tumors. A multivalent vaccine encapsulating both insoluble soluble bacterial antigens was developed, addressing shortcomings antibacterial by balancing broad antigen coverage with effective immune activation. This induces robust downstream responses F. S. E. demonstrating notable preventive efficacy bacteria-induced metastasis models. Unexpectedly, vaccinated infected mice showed even slower tumor than uninfected mice. Overall, study validates potential nanovaccines modulating microbiome for therapy highlights tumor-associated infections promising antitumor targets.
Язык: Английский
Процитировано
0
ACS Nano, Год журнала: 2025, Номер unknown
Опубликована: Апрель 10, 2025
The immune-modulatory properties of metal ions have contributed to vaccination and immunotherapy (i.e., metalloimmunotherapy) for the prevention treatment various diseases. Developing an enabling approach that can readily incorporate in vaccine formulations deliver them with controllable pharmacokinetics targeting ability is ongoing endeavor. Herein, we report a simple highly effective metal-phenolic assembly approach, whereby both ovalbumin (a model antigen) immune-responsive AlIII MnII) are immobilized within biocompatible coordination network form vaccines (MPNVs) under mild conditions. MPNVs demonstrated specific lymph node accumulation elicited humoral cellular immune responses following their subcutaneous intramuscular administration mice. Mice immunized maintained robust antibody response at least 10 weeks, comparable commercial aluminum adjuvant. modularity afforded dual-metal incorporation into (MPNVMn+Al), which amplified up 11-fold compared mixture OVA, AlIII, MnII OVA + Al Mn). Moreover, showed anticancer suppressing development B16F10 melanoma Specifically, MPNVMn+Al led 5-fold reduction tumor volume 6.6-fold decrease metastatic nodule number, Mn. This work provides insights activity metal-organic materials, underpinning rational design therapeutic platforms based on these materials.
Язык: Английский
Процитировано
0
Advanced Healthcare Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 24, 2025
Abstract Tumor vaccines have shown great promise for treating various malignancies; however, glioblastoma (GBM), characterized by its immunosuppressive tumor microenvironment, high heterogeneity, and limited accessibility, has achieved only modest clinical benefits. Here, it is reported that GBM cell lysate nanovaccines boosted with TLR9 agonist CpG ODN (GlioVac) via a strategic vaccination regimen achieve complete regression of malignant murine tumors. Subcutaneous administration GlioVac promotes uptake cervical lymph nodes antigen presentation cells, bolstering cross‐presentation infiltration GBM‐specific CD8 + T cells into the tumor. Notably, involving two subcutaneous three intravenous vaccinations not activates systemic anti‐GBM immunity but also further enhances cytotoxic lymphocytes, effectively reshaping “cold” “hot” This approach led to state tumor‐free survival in 5 out 7 mice bearing established GL261 model protection from rechallenge. In an orthotopic hRas‐GBM induced lentiviral plasmid, resulted ≈100% regression. These findings suggest provides personalized therapeutic vaccine strategy glioblastoma.
Язык: Английский
Процитировано
0
Science Advances, Год журнала: 2025, Номер 11(18)
Опубликована: Май 1, 2025
Pulmonary fibrosis (PF) is a life-threatening interstitial lung disease, characterized by excessive fibroblast activation and collagen deposition, leading to progressive pulmonary function decline limited therapeutic efficacy. Here, the inhalable, myofibroblast-targeted, pH-responsive liposomes (FL-NI) were developed for effective codelivery of nintedanib, mainstream antifibrotic drug in clinic, siIL11, small interfering RNA that silences key profibrosis cytokine IL-11. Notably, FL-NI achieved 117.8% increase delivery noninvasive inhalation 71.5% specifically protein-positive myofibroblasts while reducing nonspecific immune cell epithelial uptake 29.8 55.8%, respectively. The accurate nintedanib siIL11 into synergistic effects, effectively enhanced myofibroblast deactivation, reduced pathological deposition 50.8%, promoted tissue repair. remodeled aberrant microenvironment without inducing systemic toxicities. Therefore, this work demonstrated notable potential pluripotent strategy improving PF outcomes its promising clinical translation.
Язык: Английский
Процитировано
0
Advanced Functional Materials, Год журнала: 2025, Номер unknown
Опубликована: Май 28, 2025
Abstract Due to the resistance immunotherapies is prevalent, exploring universal immune activation strategies are necessary. Pathogenic systems can inherently stimulate innate immunity and may potentially boost anti‐tumor response; however, their safety profile not optimal. In this study, a pathogen‐mimicking cancer vaccine (DFC‐YM) based on engineered tumor cells introduced potentiate in colon treatment. By activating viral‐related genes within inducing transcription of endogenous double‐stranded RNA, DFC‐YM endowed with virus‐like genome inside. With externally modification nano‐sized yeast membrane particles (YM), simulate surface structure characteristics microorganisms. Upon administration, exhibits pathogen‐like characteristics, capable recruiting substantial number cells, particularly neutrophils, dendritic macrophages, thereby impeding progression cancer. When further combined prostaglandin E2 inhibitor, increase CD8 + T lymphocyte populations, demonstrating an enhanced therapeutic efficacy. This innovative strategy presents new concept for development broad‐spectrum immunotherapeutic approaches against
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2024, Номер unknown, С. 157911 - 157911
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
0