Emodin Enhanced Microwave‐Responsive Heterojunction with Powerful Bactericidal Capacity and Immunoregulation for Curing Bacteria‐Infected Osteomyelitis DOI Creative Commons
Tao Xu, Hao Cheng, Hailong Pei

и другие.

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 27, 2024

Abstract Eradication of osteomyelitis caused by bacterial infections is still a major challenge. Microwave therapy has the inherent advantage deep penetration in curing tissue infections. However, antibacterial efficiency sensitizers limited weak energy microwaves. Here, hybrid heterojunction system (Fe 3 O 4 /CuS/Emo) designed for bacterially infected osteomyelitis. As an enhanced microwave sensitizer, it shows supernormal response ability. Specifically, Fe acts as matrix to mediate magnetic loss. After CuS loading, heterogeneous interface forms induce significant interfacial polarization, which increasing dielectric On basis formed two semiconductors, emodin innovatively introduced modify it. This integration not only accelerates movement charge carriers but also enhances polarization loss due numerous functional groups present on surface. further optimizes thermal and catalytic response. In addition, unique anti‐inflammatory properties confer ability regulate immune microenvironment. vivo studies reveal that modified programmed elimination bacteria regulation It offers revolutionary approach treatment

Язык: Английский

Yolk–Shell CoNi@N-Doped Carbon-CoNi@CNTs for Enhanced Microwave Absorption, Photothermal, Anti-Corrosion, and Antimicrobial Properties DOI Creative Commons

Qiqin Liang,

Mukun He,

Beibei Zhan

и другие.

Nano-Micro Letters, Год журнала: 2025, Номер 17(1)

Опубликована: Фев. 26, 2025

Abstract The previous studies mainly focused on improving microwave absorbing (MA) performances of MA materials. Even so, these designed materials were very difficult to be employed in complex and changing environments owing their single-functionalities. Herein, a combined Prussian blue analogues derived catalytical chemical vapor deposition strategy was proposed produce hierarchical cubic sea urchin-like yolk–shell CoNi@N-doped carbon (NC)-CoNi@carbon nanotubes (CNTs) mixed-dimensional multicomponent nanocomposites (MCNCs), which composed zero-dimensional CoNi nanoparticles, three-dimensional NC nanocubes one-dimensional CNTs. Because good impedance matching attenuation characteristics, the CoNi@NC-CoNi@CNTs MCNCs exhibited excellent performances, achieved minimum reflection loss ( RL min ) −71.70 dB at 2.78 mm Radar Cross section value −53.23 m 2 . More importantly, acquired results demonstrated that presented photothermal, antimicrobial anti-corrosion properties structure, highlighting potential multifunctional applications. It could seen this finding not only generalizable route magnetic NC-CNTs-based MCNCs, but also provided an effective develop improve environmental adaptabilities.

Язык: Английский

Процитировано

12

Multifunctional Fe3O4@ZIF-8@Ag nanocomposites and electro-driven droplet adsorption strategy for SERS detection of acetamiprid DOI
Xuemei Tang, Wei Zeng, Chunyong Wang

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161149 - 161149

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1

Sono-piezodynamic therapy for drug-resistant bacteria infection DOI Creative Commons
Shuai He, Wenxuan He,

Hongxing Shi

и другие.

Cell Reports Physical Science, Год журнала: 2025, Номер 6(3), С. 102451 - 102451

Опубликована: Фев. 20, 2025

Язык: Английский

Процитировано

0

Bacterial Capture‐Killing Capsules with Remodeling Bone Immune Microenvironment for the Effective Treatment of Osteomyelitis DOI Creative Commons
Dong Yang, Chang Shu, Chengwei Xu

и другие.

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

Abstract Osteomyelitis represents a significant health concern, characterized by bacterial infection that can potentially present considerable challenge to clinical treatment. Current treatment strategies, including prolonged antibiotic regimens and surgical debridement, often fail adequately resolve or support bone regeneration, largely due the pathogen‐induced dysregulation of microenvironment. This study reports multifunctional capsule achieves coordinated capture‐killing immunomodulatory within osseous tissue, effectively resolving dual pathological challenges persistent microenvironment dysregulated regeneration inherent osteomyelitis. The capsules, PC‐O@TOB, are based on Schiff base reaction procyanidins (PC) with amino Lysine6‐osteogenic growth peptide (K6‐OGP) tobramycin (TOB), which allows for efficient loading controllable release K6‐OGP TOB. In vitro in vivo studies demonstrated PC‐O@TOB exhibits functionality: potent bactericidal activity through capture localized delivery, microenvironmental remodeling via ROS scavenging M2 macrophage polarization. effect synergizes capsule's osteogenic angiogenic properties accelerate repair. strategy antibacterial later has opened up new way

Язык: Английский

Процитировано

0

Microwave‐Responsive AlEu‐MOFs Potentiate NLRP3‐Mediated Pyroptosis via a “Triple Initiating” Tactic for Breast Cancer Microwave‐Immunotherapy DOI
Qiong Wu,

Lirong Zhao,

Longfei Tan

и другие.

Small, Год журнала: 2025, Номер unknown

Опубликована: Май 9, 2025

Abstract Microwave thermotherapy is favored in clinical practice for breast cancer conservation strategies due to its minimally invasive characteristic. Nevertheless, the immunosuppressive tumor microenvironment (TME) significantly attenuates therapeutic efficacy of anti‐tumor immune response, posing challenges effectively preventing recurrence and metastasis. Pyroptosis, a recently identified form programmed cell death triggered by inflammasomes, presents unique inflammatory immunogenic properties that hold promise immunotherapy. Herein, microwave‐responsive AlEu‐MOFs are designed synthesized boost NLRP3‐mediated pyroptosis via “Triple Initiating” tactic microwave‐immunotherapy. The potent microwave thermal effect AEM facilitates up‐regulation HSP90, thereby initiating NLRP3 expression. Concurrently, it induces mitochondrial dysfunction generate substantial quantities ROS, further enhancing expression achieve targeted amplification thermotherapy‐induced pyroptosis. Simultaneously, directed anchoring release highly active metal ions promotes activation inflammasome jointly, ultimately inducing high‐efficiency This innovative “2M” (materials methods) dual‐pronged strategy not only inhibits primary proliferation, but also impedes distant progression lung work provides novel accurately offers new approach overcome obstacles thermotherapy.

Язык: Английский

Процитировано

0

Microwave-responsive ionic liquid with enhanced bactericidal, biocompatible and immunoregulatory properties for the prevention of abdominal adhesion DOI

Wei Ye,

Zhe Cui,

Lingwan Hao

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 164421 - 164421

Опубликована: Июнь 1, 2025

Язык: Английский

Процитировано

0

Emodin Enhanced Microwave‐Responsive Heterojunction with Powerful Bactericidal Capacity and Immunoregulation for Curing Bacteria‐Infected Osteomyelitis DOI Creative Commons
Tao Xu, Hao Cheng, Hailong Pei

и другие.

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 27, 2024

Abstract Eradication of osteomyelitis caused by bacterial infections is still a major challenge. Microwave therapy has the inherent advantage deep penetration in curing tissue infections. However, antibacterial efficiency sensitizers limited weak energy microwaves. Here, hybrid heterojunction system (Fe 3 O 4 /CuS/Emo) designed for bacterially infected osteomyelitis. As an enhanced microwave sensitizer, it shows supernormal response ability. Specifically, Fe acts as matrix to mediate magnetic loss. After CuS loading, heterogeneous interface forms induce significant interfacial polarization, which increasing dielectric On basis formed two semiconductors, emodin innovatively introduced modify it. This integration not only accelerates movement charge carriers but also enhances polarization loss due numerous functional groups present on surface. further optimizes thermal and catalytic response. In addition, unique anti‐inflammatory properties confer ability regulate immune microenvironment. vivo studies reveal that modified programmed elimination bacteria regulation It offers revolutionary approach treatment

Язык: Английский

Процитировано

1