Novel Mitochondria-Targeted Asymmetric Heptamethine Cyanine Dye for Cancer Targeted NIR Imaging and Potent Necrosis and Senescence Induction with Prolonged Retention DOI
Shuguang Zeng, Linxia Liu,

Qi Cheng

и другие.

Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 11, 2025

Developing small molecules that inherently integrate highly tumor-targeted near-infrared fluorescence (NIRF) imaging with potent therapeutic effects remains challenging in anticancer theranostics. Here, we synthesized and characterized a series of heptamethine cyanine PSs symmetric asymmetric structures. Among them, first discovered structures significantly enhanced tumor targeting. Also, novel mitochondria-targeted compound 17 exhibited superior NIRF capability, exceptional selectivity (TNR = 8.54), strong antitumor activity. Compound selectively accumulates mitochondria, driven by MMP, where it generates ROS, induces DNA damage, triggers senescence, apoptosis, necrosis. Its efficacy was demonstrated across multiple models, including patient-derived xenograft (PDX), allowed precise visualization, suppressed growth single administration, showed no detectable toxicity. Notably, the single-dye molecule retained tumors for over 120 h, enabling prolonged imaging, targeted therapy, drug delivery integrated treatment.

Язык: Английский

Molecularly Engineered NIR-II Emitting Carbon Dots Assemblies for Unprecedented High-Resolution Angiography and Synergistic Photodynamic/Photothermal Tumor Therapy DOI

Xiaokuang Xue,

Jian Li,

Tiejin Chen

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер 505, С. 159356 - 159356

Опубликована: Янв. 7, 2025

Язык: Английский

Процитировано

1
Nanotheranostics with Radionuclides for Cancer Diagnosis and Therapy DOI Open Access

Minhui Cui,

Mengmeng Zhu, Dongsheng Tang

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 9, 2025

Abstract Anti‐tumor theranostic radionuclide nanosystems have gained significant attention as an emerging therapeutic strategy. This review systematically elucidates the concept and recent advances of anti‐tumor nanotheranostic systems with radionuclides, a focus on design nanocarriers, precise selection their advantages limitations in clinical translation. also explores integration imaging various treatment modalities, including photodynamic therapy, photothermal sonodynamic immunotherapy. Furthermore, combination therapy fluorescence magnetic resonance technologies, which broadens application nanotheranostics, is discussed. Finally, outlooks future development nanotheranostics radionuclides proposes key research focus.

Язык: Английский

Процитировано

1
A Smart Visualized Phototherapy Switch: From NIR‐I Imaging‐Guided Photodynamic Therapy to NIR‐II‐Guided Photothermal Therapy for Enhanced Cascade Tumor Photoablation DOI Creative Commons
Lixin Sun, Hongyu Wu, Ziwen Zhang

и другие.

Aggregate, Год журнала: 2025, Номер unknown

Опубликована: Фев. 11, 2025

ABSTRACT Imaging‐guided phototherapy holds promise for precision cancer treatment. However, most photosensitizers have only a singular modality of photodynamic therapy (PDT) or photothermal (PTT), which make their therapeutic efficacy severely limited by the hypoxic and complex tumor microenvironment (TME). In this article, we provide smart platform design (BOD‐D) based on visualized light‐triggered phototherapeutic switch transforming from near‐infrared (NIR)‐I imaging‐guided PDT to activatable NIR‐II‐guided PTT while releasing nitric oxide (NO) gas (GT). BOD‐D releases native NIR one‐region fluorescence signals in tumors, is used direct robust killing. As administered, decreasing oxygen content TME becomes progressively insufficient maintain its excellent cell‐killing effect. Subsequently, light triggers dissociation NO BOD‐D, activating agent BOD‐T that emits NIR‐II fluorescence, subsequent PTT. Notably, not light‐mediated mechanism can be switched NIR‐I‐guided PTT, but also released during process will GT sensitize above Our study contributes intelligent cascade photoablation.

Язык: Английский

Процитировано

0
A cyanine fluorophore for imaging-guided tumor photodynamic and photothermal therapy under NIR-II light activation DOI
Wenkai Liu,

Chengyuan Lv,

Yanxian Hou

и другие.

Science China Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

Язык: Английский

Процитировано

0
Immunomodulating Platelet-mimicking Nanoparticles for AIE-based Enhanced Photodynamic Immunotherapy against Lung Cancer DOI Creative Commons
Yuan Zhang,

Zhiji Wang,

Jia Wang

и другие.

Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101683 - 101683

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Ultrasound‐Triggered Cascade Delivery via Poly‐Oxaliplatin Nanoparticles for Immunotherapy DOI Open Access

Meifang Shen,

Yushu Wang, Lingpu Zhang

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

Abstract Oxaliplatin (OXA), a third‐generation platinum‐based chemotherapeutic agent, is widely utilized in cancer treatment due to its potent cytotoxic effects and ability induce immunogenic cell death (ICD). However, the clinical application of OXA significantly hindered by inefficient drug delivery. To address these challenges, cascade delivery system that integrates ultrasound (US) activation with Poly‐Oxaliplatin nanoparticles (OXA‐Ce6 NP) developed enhance therapeutic efficacy overcome resistance mechanisms OXA. This sono‐responsive platform consists an amphiphilic polymer incorporating OXA(IV) prodrug (Poly‐OXA(IV)) sonosensitizer chlorin e6 (Ce6), enabling US‐triggered cascade. Upon US exposure, this facilitates 1) enhanced cellular uptake via increased membrane permeability, 2) situ through electron transfer, 3) augmented formation OXA‐DNA adducts, thereby intensifying DNA damage effects. Moreover, US‐induced reactive oxygen species (ROS) further potentiate ICD, remodeling tumor immune microenvironment promoting systemic antitumor immunity. By leveraging as external stimulus, enhances outcome while mitigating toxicity. strategy provides versatile approach optimizing chemotherapy integrating immunotherapy, offering promising avenue for improving treatments.

Язык: Английский

Процитировано

0
Ultrasound-Energized OX40L-Expressing Biohybrid for Multidimensional Mobilization of Sustained T Cell-Mediated Antitumor Immunity and Potent Sono-Immunotherapy DOI

Mengyun Liang,

Xiaoying Kang,

Hanwen Liu

и другие.

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Апрель 9, 2025

Harnessing immunostimulation to reinvigorate antitumor effector immune cells represents a promising strategy for tumor eradication. However, achieving durable clinical outcomes necessitates multidimensional activation sustain robust responses. Here, we present an ultrasound-empowered living biohybrid that strategically mobilizes T-cell-mediated immunity potent sono-immunotherapy. Through synthetic biology, engineer bacteria express fusion protein encoding the costimulatory OX40 ligand (OX40L), and further functionalize them with high-performance polymer sonosensitizer tethered via reactive oxygen species-cleavable linker. Upon ultrasound irradiation, sono-activated nanocargoes detach from bacterial surface, facilitating cellular entry exposing immune-stimulating OX40L. The sonodynamic effects, coupled native immunogenicity of bacteria, promotes tumor-associated antigen release, fosters proinflammatory microenvironment, drives dendritic cell maturation, thereby priming cytotoxic T-cell activation. OX40L expressed by engineered amplifies sustains activity, orchestrating response. This cascade-amplified effectively suppresses growth, induces long-lasting memory, provides protection against metastasis recurrence, significantly enhancing survival outcomes. By integrating ultrasound-energized nanoadjuvants boosters, this hybrid biotherapeutic platform offers versatile powerful activation, advancing frontier cancer

Язык: Английский

Процитировано

0
Novel Mitochondria-Targeted Asymmetric Heptamethine Cyanine Dye for Cancer Targeted NIR Imaging and Potent Necrosis and Senescence Induction with Prolonged Retention DOI
Shuguang Zeng, Linxia Liu,

Qi Cheng

и другие.

Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 11, 2025

Developing small molecules that inherently integrate highly tumor-targeted near-infrared fluorescence (NIRF) imaging with potent therapeutic effects remains challenging in anticancer theranostics. Here, we synthesized and characterized a series of heptamethine cyanine PSs symmetric asymmetric structures. Among them, first discovered structures significantly enhanced tumor targeting. Also, novel mitochondria-targeted compound 17 exhibited superior NIRF capability, exceptional selectivity (TNR = 8.54), strong antitumor activity. Compound selectively accumulates mitochondria, driven by MMP, where it generates ROS, induces DNA damage, triggers senescence, apoptosis, necrosis. Its efficacy was demonstrated across multiple models, including patient-derived xenograft (PDX), allowed precise visualization, suppressed growth single administration, showed no detectable toxicity. Notably, the single-dye molecule retained tumors for over 120 h, enabling prolonged imaging, targeted therapy, drug delivery integrated treatment.

Язык: Английский

Процитировано

0