Ultrasound-responsive nanoweapons: covalent organic frameworks for cancer sonodynamic therapy DOI
Yu Shrike Zhang, Chunyuan Hou, Bin Zhu

и другие.

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Sonodynamic therapy (SDT), characterized by its non-invasiveness, low toxicity, and deep tissue penetration, has emerged as a promising therapeutic modality for anticancer treatments. Recently, covalent organic frameworks (COFs) have garnered significant attention in the SDT realm powerful versatile toolbox. Notably, COF-based achieved many encouraging outcomes owing to remarkable potential of COFs, volume related research experienced continuous growth. Therefore, we strive provide timely comprehensive review that thoroughly summarizes advancements SDT. This begins with concise yet summary ultrasonic cavitation sonodynamic effects, elucidating fundamental principles mechanisms Subsequently, it delves into chemistry examining intricate structure designs, various types linkages, diverse synthetic methods. The primary focus this is summarize sonosensitizers, including construction strategies product properties. More importantly, role COFs combined therapies described detail, aiming highlight advantages COF-enhanced synergistic Finally, points out current challenges future opportunities rapidly evolving field. Overall, deliberations overviews sonosensitizers are expected facilitate advancements, leading early-stage clinical benefits patients.

Язык: Английский

Advanced materials for cancer treatment and beyond DOI Creative Commons
Lei Zhang, Yanan Wang,

Yang‐Jia Li

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 5, 2025

Conservative anti-cancer treatment represented by chemotherapy and surgery lacks tumor-specificity could hardly resolve the problems associated with multidrug resistance (MDR) in cancers. Novel therapeutic materials cancer treatment, such as those anti-MDR or controllable features, represent a significant trend due to their advantages of high specific efficacy timely intervention progress. In addition excellent biocompatibility specificity, they can be utilized therapies that require ease operation, provided are designed detection sensitivity. this review, we summarize series recently developed exhibit these advantages, including immune-enhancing tumor microenvironment (TME)- responsive materials, integrated imaging capabilities. We also introduce advanced modification approaches impart essential targeting functionalities materials.

Язык: Английский

Процитировано

0
Ultrasound-responsive nanoweapons: covalent organic frameworks for cancer sonodynamic therapy DOI
Yu Shrike Zhang, Chunyuan Hou, Bin Zhu

и другие.

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Sonodynamic therapy (SDT), characterized by its non-invasiveness, low toxicity, and deep tissue penetration, has emerged as a promising therapeutic modality for anticancer treatments. Recently, covalent organic frameworks (COFs) have garnered significant attention in the SDT realm powerful versatile toolbox. Notably, COF-based achieved many encouraging outcomes owing to remarkable potential of COFs, volume related research experienced continuous growth. Therefore, we strive provide timely comprehensive review that thoroughly summarizes advancements SDT. This begins with concise yet summary ultrasonic cavitation sonodynamic effects, elucidating fundamental principles mechanisms Subsequently, it delves into chemistry examining intricate structure designs, various types linkages, diverse synthetic methods. The primary focus this is summarize sonosensitizers, including construction strategies product properties. More importantly, role COFs combined therapies described detail, aiming highlight advantages COF-enhanced synergistic Finally, points out current challenges future opportunities rapidly evolving field. Overall, deliberations overviews sonosensitizers are expected facilitate advancements, leading early-stage clinical benefits patients.

Язык: Английский

Процитировано

0