Addressing the challenges of infectious bone defects: a review of recent advances in bifunctional biomaterials

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 29, 2025

Infectious bone defects present a substantial clinical challenge due to the complex interplay between infection control and regeneration. These often result from trauma, autoimmune diseases, infections, or tumors, requiring nuanced approach that simultaneously addresses promotes tissue repair. Recent advances in engineering materials science, particularly nanomaterials nano-drug formulations, have led development of bifunctional biomaterials with combined osteogenic antibacterial properties. offer an alternative traditional grafts, minimizing complications such as multiple surgeries, high antibiotic dosages, lengthy recovery periods. This review examines repair mechanisms infectious microenvironment highlights various foster both anti-infective processes. Emerging design strategies are also discussed provide forward-looking perspective on treating clinically significant outcomes.

Язык: Английский

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Application of Light-Responsive Nanomaterials in Bone Tissue Engineering

Pharmaceutics, Год журнала: 2025, Номер 17(1), С. 98 - 98

Опубликована: Янв. 13, 2025

The application of light-responsive nanomaterials (LRNs) in bone tissue engineering shows broad prospects, especially promoting healing and regeneration. With a deeper understanding the mechanisms defects disorders, LRNs are receiving increasing attention due to their non-invasive, controllable, efficient properties. These materials can regulate cellular biological reactions promote cell adhesion, proliferation, differentiation by absorbing specific wavelengths light converting them into physical chemical signals. In addition, unique surface morphology biocompatibility enable effectively load drugs engineering, achieve precise release, optimize regeneration process. Through photothermal photodynamic therapy, these also possess antibacterial properties play an important role repair infectious defects. Although have shown significant advantages regeneration, series challenges still need be overcome widespread effective clinical applications. This article summarizes basic principles, classification, potential applications aiming provide reference for future research

Язык: Английский

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An Artificial Piezoelectric-Conductive Integrated Peri-Implant Gingiva Enables Efficient Bacterial Inhibition and Soft-Tissue Integration

Advanced Fiber Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 24, 2025

Язык: Английский

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Enhancing Near-Infrared Photothermal Activity through Precise In-Plane Interface Engineering in CuS-Au and CuS@Au Ultrathin Nanoplates for Combating Multidrug-Resistant Bacteria

Journal of Materials Chemistry C, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Ultrathin two-dimensional hybrid nanostructures are crafted with well-designed copper sulfide–gold interfaces, demonstrating exceptional near-infrared photothermal properties to kill multidrug-resistant bacteria.

Язык: Английский

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Recyclable Dynamic Hydrogen Bonding and Disulfide Based Polymer‐Silver Nanoparticle Hybrid Triboelectric Nanogenerator for Artificial Intelligence‐Assisted High‐Precision Smart Insoles

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 19, 2025

Abstract With rapid advancement in the field of smart technology, reshapeable devices have garnered widespread interest. Liquid‐free flexible materials eliminate risk leakage thus enhancing user safety along with being recyclable. However, poor network fluidity and difficulty fully disconnecting cross‐links limited its potential as a device. In this work, silver nanoparticles (AgNPs) are doped into physically cross‐linked dynamic linear polydimethylsiloxane (PIAU) to develop closed‐loop recyclable high‐dielectric nanocomposite. This nanocomposite exhibits moderate elastoviscosity‐transition temperature spatial remodelability based on multiple types reversible hydrogen bonds S─Ag bonds. AgNPs sprayed surface form conductive coating stabilized by at polymer‐nano interface. Based refined assembly, an antibacterial triboelectric nanogenerator (TENG) is developed applied high‐precision insole. The insole 16 TENG sensors, resulting simplified system that employs machine learning (ML) for personalized motion monitoring, including recognition gait classification. Five algorithm models ensure high accuracy enable it further expand abnormal alarm system. work presents new reliable environmentally friendly strategy design high‐performance sustainable devices.

Язык: Английский

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Vacancies-Rich Z-Scheme VdW Heterojunction as H2S-Sensitized Synergistic Therapeutic Nanoplatform against Refractory Biofilm Infections

Biomaterials, Год журнала: 2025, Номер 320, С. 123258 - 123258

Опубликована: Март 13, 2025

Язык: Английский

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Glucose-Triggered NO-Evolving Coating Bestows Orthopedic Implants with Enhanced Anti-Bacteria and Angiectasis for Safeguarding Diabetic Osseointegration

Biomaterials, Год журнала: 2025, Номер unknown, С. 123334 - 123334

Опубликована: Апрель 1, 2025

Язык: Английский

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Self-assembled Janus structure nanofiber membranes for skin wound healing: Synergistic Photothermal and Chemical Antibacterial Strategies

Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2025, Номер unknown, С. 136921 - 136921

Опубликована: Апрель 1, 2025

Язык: Английский

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Injectable dual-network hydrogel for phototherapy and immunomodulation in the treatment of MRSA-infected and diabetic wound

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 163026 - 163026

Опубликована: Апрель 1, 2025

Язык: Английский

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Advances of functional nanomaterials as either therapeutic agents or delivery systems in the treatment of periodontitis

Biomaterials Advances, Год журнала: 2025, Номер 175, С. 214326 - 214326

Опубликована: Апрель 27, 2025

Язык: Английский

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