Bioactive Materials, Год журнала: 2025, Номер 51, С. 634 - 649
Опубликована: Май 31, 2025
Язык: Английский
Materials Today Bio, Год журнала: 2025, Номер 32, С. 101782 - 101782
Опубликована: Апрель 19, 2025
Язык: Английский
Процитировано
1
World Journal of Hepatology, Год журнала: 2025, Номер 17(2)
Опубликована: Фев. 20, 2025
BACKGROUND The liver exerts profound influence on skeletal health, while osseous tissues reciprocally modulate hepatic function. This bidirectional metabolic axis between these two organ systems plays a pivotal role in both physiological homeostasis and pathological states. AIM To investigate analyze the literatures liver-bone using bibliometrics. METHODS A comprehensive literature search pertaining to was conducted Science Citation Index Expanded within Web of Core Collection. Subsequently, visualization bibliometric analyses were performed utilizing VOSviewer (version 1.6.20), Citespace 6.2.R4), R programming language. RESULTS analysis encompasses 855 publications, comprising 694 articles 161 reviews, authored by 4988 researchers from 425 institutions across 61 countries. United States China emerge as leading nations terms publication volume. University California system stands out most influential institution research. Guanabens N is identified prolific author this field. annual increase publications related underscores its growing prominence research focus. study highlights key areas investigation, including osteoporosis, bone metabolism, non-alcoholic fatty disease, insulin-like growth factor-1, which represent current prospective hot topics domain. CONCLUSION investigation employs methodologies conduct systematic spanning 2001 2024. exponential over past decades significance synthesizing outcomes Through rigorous statistical analyses, we delineate fundamental contributions field providing strategic direction for emerging scholars. Furthermore, illuminate trajectories identify promising future investigative directions. Investigation enhances our comprehension inter-organ communication networks. Conceptualizing organs an integrated provides insights into pathophysiological mechanisms disease management strategies. paradigm not only facilitates development sophisticated diagnostic modalities but also catalyzes discovery novel therapeutic agents targeting mechanistic pathways, thereby advancing capacity diagnose treat disorders.
Язык: Английский
Процитировано
0
Discover Nano, Год журнала: 2025, Номер 20(1)
Опубликована: Март 30, 2025
The aim of this study was to explore the bibliometric analysis nanomaterials-based therapies for hepatocellular carcinoma as a means assessing current state development and future trends in field. Literature on nanomedicine interactions searched from core database Web Science visualisation analyses were performed using VOSviewer, CiteSpace GraphPad Prism data software. We focused important keywords, countries, authors, affiliations, journals, literature field nanomaterials HCC. search resulted finalization 421 documents. From 2008 2023, research HCC has developed rapidly, number published papers steadily increased, increasing by about 2300%. There are currently 57 countries involved area. Among them, USA had strongest international cooperation network cooperated most closely with China. Gene delivery carbon nanotubes early immunotherapy nanocarriers recent hotspots. It is that selection drug have become driving carcinoma. combination traditional imaging techniques such MRI can improve diagnosis rate Nanomaterials achieve precise targeting cancer cells encapsulating drugs, loading bioactive molecules or modifying specific ligands, thus significantly improving efficacy effectively reducing adverse reactions therapy.
Язык: Английский
Процитировано
0
ACS Applied Polymer Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 10, 2025
Язык: Английский
Процитировано
0
Advanced Materials, Год журнала: 2025, Номер unknown
Опубликована: Май 16, 2025
Abstract The reliance on high levels of methionine by tumor cells provides an attractive target for cancer treatment. However, systemic blockade may raise concerns about potential side effects given the broad and essential functions in cellular metabolism. Here, a combined drug delivery platform multilayered constraint within lesions is developed. Small molecule inhibitors PF9366 adenosine dialdehyde are encapsulated cell‐targeting nanoparticles (NPs) to achieve cascaded blockage intracellular These NPs further co‐loaded with extracellular uptake inhibitor JPH203 into type reactive oxygen species‐sensitive hydrogel, assembling multiplex modulating hydrogel (3 M Gel). In murine models triple‐negative breast (TNBC), hepatocellular carcinoma, colorectal cancer, situ formed 3 Gel exhibits superior efficacy restricting S‐adenosyl generation histone methylation, stimulating immunogenic cell death cells, thereby eliciting potent innate adaptive immune responses restrain progression. Moreover, remodeling microenvironment overcomes checkpoint resistance TNBC. This study presents localized triple regulation strategy paves new path amino acid starvation‐based therapy.
Язык: Английский
Процитировано
0
Bioactive Materials, Год журнала: 2025, Номер 51, С. 634 - 649
Опубликована: Май 31, 2025
Язык: Английский
Процитировано
0