Advancing cancer gene therapy: the emerging role of nanoparticle delivery systems DOI Creative Commons
Mao‐Ze Wang, Huina Liu, Jinling Huang

и другие.

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Май 20, 2025

Gene therapy holds immense potential due to its ability precisely target oncogenes, making it a promising strategy for cancer treatment. Advances in genetic science and bioinformatics have expanded the applications of gene delivery technologies beyond detection diagnosis therapeutic interventions. However, traditional faces significant challenges, including limited efficacy rapid degradation materials vivo. To address these limitations, multifunctional nanoparticles been engineered encapsulate protect materials, enhancing their stability effectiveness. Nanoparticles are being extensively explored deliver various payloads-including plasmid DNA, messenger RNA, small interfering RNA-directly cells. This review highlights key modulation strategies such as RNA interference, editing systems, chimeric antigen receptor (CAR) technologies, alongside diverse array nanoscale systems composed polymers, lipids, inorganic materials. These nanoparticle-based platforms aim improve targeted transport material into cells, ultimately therapies.

Язык: Английский

Gut microbiota reshapes the TNBC immune microenvironment: Emerging immunotherapeutic strategies DOI Creative Commons
Mingyao Huang, Yikai Zhang,

Zhaoji Chen

и другие.

Pharmacological Research, Год журнала: 2025, Номер 215, С. 107726 - 107726

Опубликована: Апрель 4, 2025

Triple-negative breast cancer (TNBC) is an aggressive subtype of with limited treatment options and poor prognosis. The gut microbiota, a diverse community microorganisms in the gastrointestinal tract, plays crucial role regulating immune responses through gut-immune axis. Recent studies have highlighted its significant impact on TNBC progression efficacy immunotherapies. This review examines interactions between microbiota system TNBC, focusing key cells pathways involved tumor immunity. It also explores modulation strategies, including probiotics, prebiotics, dietary interventions, fecal transplantation, as potential methods to enhance immunotherapeutic outcomes. Understanding these mechanisms offers promising avenues for improving patient prognosis TNBC.

Язык: Английский

Процитировано

0
Advancing cancer gene therapy: the emerging role of nanoparticle delivery systems DOI Creative Commons
Mao‐Ze Wang, Huina Liu, Jinling Huang

и другие.

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Май 20, 2025

Gene therapy holds immense potential due to its ability precisely target oncogenes, making it a promising strategy for cancer treatment. Advances in genetic science and bioinformatics have expanded the applications of gene delivery technologies beyond detection diagnosis therapeutic interventions. However, traditional faces significant challenges, including limited efficacy rapid degradation materials vivo. To address these limitations, multifunctional nanoparticles been engineered encapsulate protect materials, enhancing their stability effectiveness. Nanoparticles are being extensively explored deliver various payloads-including plasmid DNA, messenger RNA, small interfering RNA-directly cells. This review highlights key modulation strategies such as RNA interference, editing systems, chimeric antigen receptor (CAR) technologies, alongside diverse array nanoscale systems composed polymers, lipids, inorganic materials. These nanoparticle-based platforms aim improve targeted transport material into cells, ultimately therapies.

Язык: Английский

Процитировано

0