Cryo‐Inactivated Cancer Cells Derived Magnetic Micromotors for Tumor Immunotherapy DOI Creative Commons
Qingfei Zhang, Gaizhen Kuang, Wenzhao Li

и другие.

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Май 23, 2025

Abstract Immunotherapy represents a highly promising modality in cancer treatment, with substantial advancements therapeutic strategies. The primary challenge lies enhancing the efficacy of immunotherapy approaches. Here, novel cryo‐inactivated cells (CICC) derived magnetic micromotors (CICC@FeMnP) are reported for tumor synergistic immunotherapy. Through control, CICC@FeMnP can on‐demand target and accumulate at site. FeMnP induce ferroptosis then trigger immunogenic cell death cells. CICC containing whole antigen conduct vaccination effects. Together Mn 2+ ‐mediated cGAS‐STING pathway to stimulate immune response, anti‐tumor effects be achieved. Importantly, not only facilitate establishment collaborative network enhance effective tumoricidal immunity but also long‐lasting memory These results contribute inhibition progression, recurrence lung metastasis, thereby prolonging overall survival tumor‐bearing mice. This work underscores potential an engineered biohybrid micromotor system as alternative approach against tumors.

Язык: Английский

Engineered Gold Nanoparticles for Accurate and Full-scale Tumor Treatment via pH-dependent Sequential Charge-Reversal and Copper Triggered Photothermal-Chemodynamic-Immunotherapy DOI
Jie Liu,

Wenjuan Tang,

Li Chen

и другие.

Biomaterials, Год журнала: 2025, Номер unknown, С. 123322 - 123322

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Cryo‐Inactivated Cancer Cells Derived Magnetic Micromotors for Tumor Immunotherapy DOI Creative Commons
Qingfei Zhang, Gaizhen Kuang, Wenzhao Li

и другие.

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Май 23, 2025

Abstract Immunotherapy represents a highly promising modality in cancer treatment, with substantial advancements therapeutic strategies. The primary challenge lies enhancing the efficacy of immunotherapy approaches. Here, novel cryo‐inactivated cells (CICC) derived magnetic micromotors (CICC@FeMnP) are reported for tumor synergistic immunotherapy. Through control, CICC@FeMnP can on‐demand target and accumulate at site. FeMnP induce ferroptosis then trigger immunogenic cell death cells. CICC containing whole antigen conduct vaccination effects. Together Mn 2+ ‐mediated cGAS‐STING pathway to stimulate immune response, anti‐tumor effects be achieved. Importantly, not only facilitate establishment collaborative network enhance effective tumoricidal immunity but also long‐lasting memory These results contribute inhibition progression, recurrence lung metastasis, thereby prolonging overall survival tumor‐bearing mice. This work underscores potential an engineered biohybrid micromotor system as alternative approach against tumors.

Язык: Английский

Процитировано

0