Engineering in NIR‐responsive photothermal materials and their application in wound healing administration
Deleted Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 19, 2025
Abstract
Wound
healing
is
a
complex
process
that
involves
multiple
stages
and
susceptible
to
various
challenges,
such
as
infection,
insufficient
blood
flow,
the
body's
inadequate
response
process,
which
can
be
life‐threatening
for
patient.
In
current
medical
landscape,
traditional
treatments
often
struggle
meet
high
standards
of
modern
care.
Therefore,
it
crucial
actively
explore
develop
new
drugs
or
advanced
technologies
enhance
bacterially
infected
wounds.
recent
years,
several
physical
methods
effectively
accelerate
wound
have
garnered
widespread
attention
interest.
Among
these,
Photothermal
therapy
(PTT)
has
been
extensively
utilized
in
treatment
bacterial
infections
due
its
non‐invasive,
low
toxicity,
ease
use.
The
photothermal
agents
(PTAs)
serve
core
material
PTT,
their
efficacy
significantly
influenced
by
specific
PTAs
employed.
Selecting
appropriate
essential
achieving
desired
therapeutic
effect.
This
relies
on
PTAs's
ability
efficiently
convert
wavelengths
light
energy
into
heat
upon
absorption,
thereby
generating
thermal
effect
at
site.
Consequently,
properties
PTAs,
including
conversion
efficiency,
biocompatibility,
stability
within
organism,
are
critical
factors
determine
outcome.
review
introduces
organic,
inorganic,
organic‐inorganic
hybrid
PTT
healing,
highlighting
main
applications
management
years.
Finally,
we
briefly
discuss
limitations
prospects
this
field.
Язык: Английский
Soft Matter Photonics: Interplay of Soft Matter and Light
ACS Nano,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 20, 2025
The
light-soft
matter
interaction
and
its
applications
form
the
foundation
of
Soft
Matter
Photonics,
here
termed
"Soft
Mattonics",
positioning
it
as
fertile
ground
for
developing
next-generation
photonic
technologies.
Over
past
few
decades,
this
rapidly
evolving
field
has
achieved
significant
advancements,
leading
to
successful
across
a
wide
range
disciplines,
including
optoelectronics,
photonics,
information
technology,
material
science,
robotics,
biomedicine,
astronomy.
In
Perspective,
we
provide
an
overview
Mattonics,
highlighting
recent
developments
in
light-controlled
soft
their
light
manipulating.
Additionally,
offer
insights
into
future
research
directions
with
emphasis
on
both
foundational
practical
that
will
drive
continued
growth
innovation
field.
Язык: Английский
In Situ Secondary Self‐Assembly of Near‐Infrared II J‐Aggregates: A Novel Phototheranostic Strategy for Inducing Tumor Pyroptosis
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 21, 2025
Abstract
Pyroptosis,
a
programmed
cell
death
mechanism
that
bypasses
apoptosis
resistance
and
triggers
tumor‐specific
immune
responses,
has
gained
much
attention
as
promising
approach
to
cancer
therapy.
Despite
enhancing
tumor
accumulation
extending
the
circulation
of
small‐molecule
drugs,
nanomedicines
still
face
significant
challenges,
including
poor
tissue
penetration,
resistance,
hypoxic
microenvironments.
To
overcome
these
novel
near‐infrared
II
(NIR‐II)
J‐aggregate‐based
nanomedicine
is
designed,
leveraging
an
in
situ
secondary
self‐assembly
strategy
fabricate
highly
targeted
nanoparticles
(MSDP
NPs).
These
trigger
pyroptosis
by
generating
type
I
reactive
oxygen
species,
especially
superoxide
anions,
while
simultaneously
activating
photoimmunotherapy.
In
vivo
studies
demonstrate
MSDP
NPs
achieve
efficient
penetration
prolong
retention,
which
facilitated
J‐aggregate‐driven
formation
microscale
spindle‐shaped
fibrillar
bundles
through
at
site.
This
unique
structural
transformation
enhances
tissues,
enabling
robust
NIR‐II
fluorescence
imaging
improving
therapeutic
efficacy
even
study
provides
innovative
phototheranostic
utilizes
J‐aggregates
induce
pyroptosis,
offering
potential
solution
limitations
current
Язык: Английский
Recent advances in photopharmacology: Harnessing visible light‐activated azobenzene photoswitches
Deleted Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 25, 2025
Abstract
In
the
era
of
precision
medicine,
photopharmacology
that
employs
molecular
photoswitches
offers
unique
opportunities
to
control
action
bioactive
molecules
with
high
spatiotemporal
resolution,
while
reducing
drug
side
effects,
systemic
toxicity
and
emergence
resistance.
Over
past
two
decades,
field
has
witnessed
great
achievements
in
treating
blindness,
cancer,
diabetes,
antibiotic
resistance,
name
but
a
few.
Several
challenges
remain,
however,
particular
fact
most
photopharmacological
agents
trigger
their
activity
by
Ultraviolet
light,
which
is
damaging
normal
cells
poor
tissue
permeability.
Visible
light‐activated
are
hence
highly
desirable
have
captured
keen
recent
research
interest.
This
review
highlights
strategies
for
synthesis
visible
light‐responsive
azobenzenes
(ABs)
applications
emerging
photopharmacology.
Such
photoswitchable
drugs
tremendously
extend
scope
future
vivo
applications.
Furthermore,
we
identify
current
discuss
rational
design
switches
at
higher
wavelength.
We
hope
inspire
further
into
photochemistry
novel
based
on
ABs
or
other
photoswitches,
triggered
excitation
light
“phototherapeutic
window”
650–900
nm,
ultimately
enabling
full
realization
these
“smart”
clinical
practice.
Язык: Английский
Self‐Assembled Multilayered Concentric Supraparticle Architecture
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 26, 2025
Abstract
Supraparticles
(SPs)
with
unique
properties
are
emerging
as
versatile
platforms
for
applications
in
catalysis,
photonics,
and
medicine.
However,
the
synthesis
of
novel
SPs
complex
internal
structures
remains
a
challenge.
Self‐Assembled
Multilayered
(SAMS)
presented
here
composed
concentric
lamellar
spherical
made
from
metallic
nanoparticles,
formed
synergistic
three‐way
interaction
phenomenon
between
gold
lipidoid,
gelatin,
exhibiting
interlayer
spacing
3.5
±
0.2
nm
within
self‐limited
156.8
56.6
diameter.
The
formation
is
critically
influenced
by
both
physical
(including
nanoparticle
size,
lipidoid
chain
length)
chemical
factors
elemental
composition,
cap,
organic
material),
which
collectively
modulate
surface
chemistry
hydrophobicity,
affecting
interparticle
interactions.
SAMS
can
efficiently
deliver
labile
payloads
such
siRNA,
achieving
dose‐dependent
silencing
vivo,
while
also
showing
potential
mRNA.
This
work
not
only
advances
field
SP
design
introducing
new
structure
but
demonstrates
its
nanomedicine.
Язык: Английский