Nonlight-Driven Aggregation-Induced Emission Luminogens for Bioimaging and Theranostics
Chemical & Biomedical Imaging,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 4, 2025
Aggregation-induced
emission
luminogens
(AIEgens)
have
been
prosperously
developed
and
applied
in
the
fields
of
optical
imaging
theranostics
since
its
establishment.
Nowadays,
AIEgens
can
fulfill
nearly
all
requirements
with
spectra
ranging
from
visible
to
near-infrared
wavelengths.
Although
a
variety
varying
wavelengths
functionalities
continuously
designed,
their
performance
is
heavily
dependent
on
use
conventional
light
sources,
such
as
xenon
lamps
lasers,
which
severely
hinder
further
applications
due
limited
penetration
depth
background
autofluorescence
biological
tissues.
To
mitigate
these
limitations
maximize
potential
AIEgens,
unconventional
excitation
sources
chemical
energy,
ultrasound,
X-ray
offer
effective
alternatives
that
circumvent
drawbacks
associated
traditional
light-based
constant
excitation.
In
this
Review,
we
introduce
fundamental
principles
governing
combination
highlight
recent
advancements
using
excited
by
for
bioimaging
theranostics,
discuss
current
challenges
future
perspectives
aimed
at
advancing
biomedical
AIEgens.
Язык: Английский
Recent Progress of Molecular Design in Organic Type I Photosensitizers
Small,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 26, 2025
Abstract
Photodynamic
therapy
(PDT)
represents
a
high‐efficient
and
non‐invasive
therapeutic
modality
for
current
future
tumor
treatments,
drawing
extensive
attention
in
the
fields
of
antitumor
drug
clinical
phototherapy.
In
recent
years,
photosensitizer
(PS)
market
PDT
applications
have
expanded
to
address
various
cancers
skin
diseases.
However,
hypoxic
environment
within
tumors
poses
substantial
challenge
capability
reactive
oxygen
species‐dependent
PDT.
Consequently,
researches
increasingly
focus
from
type
II
I
mechanism,
which
relies
on
radical
production
with
less
or
no
dependence.
Despite
significant
progress
development
PSs,
holistic
understanding
regarding
design
principles
these
molecules
remains
elusive.
Specifically,
electron
transfer‐mediated
are
extensively
studied
years
but
is
insufficiently
addressed
existing
reviews.
This
review
systematically
summarizes
advancements
molecular
rationales
organic
categorizing
them
into
three
key
fundamental
strategies:
modulating
PS
charge
distribution,
singlet
forbidden
via
low
triplet
excited
state,
accelerating
formation
inducing
transfer.
aims
offer
valuable
insights
advancement
anti‐hypoxia
Язык: Английский