ATP‐Triggered Ultrafine Iron Oxide Nanowires for Self‐Monitoring Tumor Therapy by T1‐Magnetic Resonance Imaging‐Guided •OH Generation DOI
Zhengtao Xu,

Chen Wang,

Zhuangzhuang Zhao

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 13, 2025

Abstract Theranostic probes that integrate diagnosis and treatment together are considered as effective tools for individual therapy. However, the separation of detection components limits precise assessment therapeutic efficacy. Herein, a novel self‐monitoring probe sensitively responds to adenosine triphosphate (ATP) was developed by ultrafine iron oxide nanowires (UIONWs) through an oleyl amine‐assisted way. The UIONWs, with diameter 1.5 nm length 75 nm, surface‐coordinated amine. UIONWs can be decomposed in ATP‐containing solution expose shielded ions. Consequently, it boost peroxidase (POD) activity activate T 1 ‐magnetic resonance imaging (MRI) signal ATP. In addition, rapidly engulfed into cells due high aspect ratio. improved ATP hydrogen peroxide (H 2 O ) within tumor leads higher hydroxyl radicals (OH) generation inhibition.In contrast, normal exhibit lower H levels, reducing cytotoxicity ensuring safety. Since both illumination ‐MRI OH ATP‐controlled, this work raised potential way self‐monitor therapy timely feedback on effects.

Язык: Английский

ATP‐Triggered Ultrafine Iron Oxide Nanowires for Self‐Monitoring Tumor Therapy by T1‐Magnetic Resonance Imaging‐Guided •OH Generation DOI
Zhengtao Xu,

Chen Wang,

Zhuangzhuang Zhao

и другие.

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 13, 2025

Abstract Theranostic probes that integrate diagnosis and treatment together are considered as effective tools for individual therapy. However, the separation of detection components limits precise assessment therapeutic efficacy. Herein, a novel self‐monitoring probe sensitively responds to adenosine triphosphate (ATP) was developed by ultrafine iron oxide nanowires (UIONWs) through an oleyl amine‐assisted way. The UIONWs, with diameter 1.5 nm length 75 nm, surface‐coordinated amine. UIONWs can be decomposed in ATP‐containing solution expose shielded ions. Consequently, it boost peroxidase (POD) activity activate T 1 ‐magnetic resonance imaging (MRI) signal ATP. In addition, rapidly engulfed into cells due high aspect ratio. improved ATP hydrogen peroxide (H 2 O ) within tumor leads higher hydroxyl radicals (OH) generation inhibition.In contrast, normal exhibit lower H levels, reducing cytotoxicity ensuring safety. Since both illumination ‐MRI OH ATP‐controlled, this work raised potential way self‐monitor therapy timely feedback on effects.

Язык: Английский

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