Cartilage Lubrication from the Perspective of Wettability
ACS Nano,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 2, 2025
Cartilage
exhibits
an
extremely
low
friction
and
very
wearability
within
the
liquid
environment
of
joint.
It
is
also
capable
switching
wettability
between
superhydrophilicity
hydrophobicity
in
both
wetting
dry
conditions
(specific
experimental
operations
or
open
wounds).
Therefore,
understanding
cartilage
lubrication
from
perspective
provides
inspiration
for
design
artificial
sections
with
motion
soft
actuators
coefficients
(COF).
In
this
review,
articular
introduced
discussed
view
wettability.
First,
basic
principles
are
described
a
focus
on
compositions
cartilage,
particular
relationship
phospholipid
layers
supramolecular
synergy
synovial
fluid
cartilage.
Subsequently,
under
different
stimuli
(such
as
shear,
pH,
temperature,
electric
field)
insights
into
lubrication.
Finally,
we
present
comprehensive
summary
delineate
challenges
domain
assisting
researchers
formulating
viable
concepts
efficient
substitution
smart
lubricating
devices.
Язык: Английский
Supramolecular Polyzwitterionic Nanoparticles with Engineered pH‐Responsiveness and Cartilage‐Penetration for Osteoarthritis Therapy
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 27, 2025
Abstract
Abnormal
friction
forces,
compact
matrix
structure,
and
dynamic
acidic
microenvironment
in
osteoarthritis
(OA)
make
it
difficult
to
remodel
cartilage
regeneration
by
integrating
prominent
inflammatory
responses
anabolism.
Here,
pH‐responsive
PSBMA‐
b
‐PColBP@KGN
nanoparticles
(PSPK
NPs)
are
developed
a
simple
supramolecular
assembly
process.
PSPK
NPs
found
reduce
the
coefficient
of
(0.028)
under
high
loading
pressure
(10.41
MPa).
The
synergistic
effect
KGN
release
coupling
deep
penetration
promotes
generation
microenvironment.
Further,
vivo
studies
confirm
potential
restoring
homeostasis,
as
evidenced
reduced
osteophyte
volume,
aligned
structures,
abundant
matrix.
This
study
provides
novel
insights
into
effects
release,
penetration,
hydration
lubrication
on
OA
treatment,
offering
strategy
for
design
tissue‐adaptive
promote
tissue
inflammation‐related
diseases.
Язык: Английский
Dough‐Kneading‐Inspired Universal Mixing Strategy for Mass Production of Multi‐Stimuli‐Responsive Hydrogels
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 5, 2025
Abstract
Inspired
by
dough
kneading,
a
straightforward
and
versatile
mixing
strategy
is
proposed
for
the
safe,
rapid,
large‐scale
production
of
smart
hydrogels.
This
approach
achieved
directly
blending
gel
powders
with
an
appropriate
amount
swelling
agent.
The
applied
possess
strong
adhesion,
enabling
them
to
function
as
both
glue
bonding
different
hydrogels
healing
agents
repairing
damaged
hydrogels,
while
their
recyclability
reusability
help
lower
costs
minimize
environmental
impact.
resulting
hydrogel,
featuring
unique
internal
heterogeneous
porous
structure,
exhibits
fast
response
speed,
excellent
recoverability,
high
fatigue
resistance.
Mechanical
tests
reveal
that
this
hydrogel
robust,
capable
resisting
large
elongations
(>400%)
without
breaking,
enduring
multiple
compressions
(53%,
10
cycles)
crushing,
maintaining
integrity
during
prolonged
immersion
(≈1032
h).
Through
precise
control
composition
spatial
distribution
replaceable
agents,
enables
customizable
architectures
selective
shape‐morphing
functionality
under
programmed
stimuli.
Overall,
scalable
paradigm
establishes
eco‐conscious
manufacturing
platform
high‐throughput
synthesis
stimuli‐responsive
materials,
positioning
it
key
enabler
next‐generation
soft
devices.
Язык: Английский