ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(34), С. 44575 - 44589
Опубликована: Авг. 20, 2024
To
control
three-dimensional
(3D)
cell
spheroid
formation,
it
is
well-known
the
surface
physicochemical
and
mechanical
properties
of
culture
materials
are
important;
however,
formation
function
3D
cells
still
unclear.
This
study
demonstrated
precise
functions
using
diblock
copolymers
containing
different
ratios
a
zwitterionic
trimethylamine
Journal of Medicinal Chemistry,
Год журнала:
2024,
Номер
67(7), С. 5168 - 5184
Опубликована: Март 29, 2024
Molecules
with
N-oxide
functionalities
are
omnipresent
in
nature
and
play
an
important
role
Medicinal
Chemistry.
They
synthetic
or
biosynthetic
intermediates,
prodrugs,
drugs,
polymers
for
applications
drug
development
surface
engineering.
Typically,
the
group
is
critical
biomedical
of
these
molecules.
It
may
provide
water
solubility
decrease
membrane
permeability
immunogenicity.
In
other
cases,
has
a
special
redox
reactivity
which
targeting
and/or
cytotoxicity.
Many
underlying
mechanisms
have
only
recently
been
discovered,
number
N-oxides
healthcare
field
rapidly
growing.
This
Perspective
article
gives
short
summary
properties
their
synthesis.
also
provides
discussion
current
explains
basic
molecular
responsible
biological
activity.
Zwitterionic
polymer
brushes
are
not
a
practical
choice
since
their
ionic
response
mechanisms
unclear,
despite
great
potential
for
surface
antifouling
modification.
Therefore,
atomic
force
microscopy
and
molecular
dynamics
simulations
investigated
the
of
electrical
properties,
hydration
protein
adhesion
three
types
zwitterionic
brushes.
The
PMPC
(poly(2-methacryloyloxyethyl
phosphorylcholine))
PSBMA
(poly(sulfobetaine
methacrylate))
in
salt
solution
exhibits
significant
accumulation
cations,
which
results
positive
shift
potential.
In
contrast,
demonstrates
no
notable
change
Furthermore,
divalent
Ca
Biomaterials Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Many
applications
of
biomaterials
require
hydrophilic
polymers
as
building
blocks,
including
hydrogels
and
nanomedicinal
devices.
Besides
enabling
sufficient
swelling
properties
in
aqueous
environments,
provide
hydration
layers,
which
are
considered
a
major
requirement
when
designing
non-fouling
surfaces
materials.
For
the
last
few
decades,
polyethylene
glycol
has
been
seen
gold
standard
for
such
applications.
However,
reports
on
its
stability
immunogenicity
have
urged
chemists
to
identify
alternatives
with
comparable
or
superior
properties.
In
addition
biopolymers,
zwitterionic
gained
increasing
attention
by
effectively
offering
an
overall
charge-neutral
scaffold
capable
forming
strong
layers.
Driven
enhanced
understanding
structure-property
relationship
materials,
poly(ylides)
emerged
new
class
polymers.
By
having
negative
charge
adjacent
positive
charge,
ylides
offer
not
only
minimal
dipole
moment
but
also
maintain
their
nature.
Despite
some
early
synthesis
during
1980s,
polymeric
were
largely
overlooked
polymers,
utility
unique
blocks
design
tools
remained
elusive.
recent
years,
several
groups
reported
Abstract
High
complex
stability
and
longitudinal
relaxivity
of
Gd‐based
contrast
agents
are
important
requirements
for
magnetic
resonance
imaging
(MRI)
because
they
ensure
patient
safety
contribute
to
measurement
sensitivity.
Charged
zwitterionic
Gd
3+
‐complexes
the
well‐known
chelator
1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic
acid
(DOTA)
provide
an
excellent
basis
development
safe
sensitive
agents.
In
this
report,
we
describe
synthesis
DOTA‐NOx,
a
DOTA
derivative
with
four
N
‐oxide
functionalities
via
“click”
functionalization
tetraazide
DOTAZA.
The
resulting
complexes
Gd‐DOTA‐NOx
Eu‐DOTA‐NOx
stable
compounds
in
aqueous
solution.
NMR‐spectroscopic
characterization
revealed
high
excess
twisted
square
antiprismatic
(TSAP)
coordination
geometry
over
(SAP).
was
found
be
r
1
=7.7
m
−1
s
(1.41
T,
37
°C),
unusually
value
comparable
weight.
We
attribute
steric
influence
ordering
effect
on
outer
sphere
water
molecules
surrounding
generated
by
strongly
hydrated
groups.
Moreover,
against
transchelation
EDTA
(200
eq)
period
36
h,
it
has
similar
vitro
cell
toxicity
as
clinically
used
DOTA‐based
GBCAs.
Langmuir,
Год журнала:
2023,
Номер
39(49), С. 17959 - 17971
Опубликована: Ноя. 30, 2023
The
use
of
surface-grafted
polymer
brushes
with
combined
low-fouling
and
antibacterial
functionality
is
an
attractive
strategy
to
fight
biofilm
formation.
This
report
describes
a
new
styrene
derivative
combining
quaternary
ammonium
group
sulfobetaine
in
one
monomer.
Surface-initiated
polymerization
this
monomer
on
titanium
polyethylene
(PE)
base
material
gave
bifunctional
brush
layers.
Grafting
was
achieved
via
surface-initiated
atom
transfer
radical
from
or
heat-induced
free-radical
plasma-activated
PE.
Both
techniques
charged
layers
thickness
over
750
nm,
as
confirmed
by
ToF-SIMS-SPM
measurements.
chemical
composition
the
polymers
XPS
FT-IR
analysis.
surface
charge,
characterized
ζ
potential,
positive
at
different
pH
values,
number
solvent-accessible
excess
groups
found
be
∼1016
N+/cm2.
led
strong
activity
against
Gram-positive
Gram-negative
bacteria
that
superior
structurally
related
contact-active
polymeric
brush.
In
addition
activity,
good
properties
dual-function
were
found.
dual
most
likely
due
combination
antifouling
sulfobetaines.
both
allows
preparation
operationally
simple
techniques.
Communications Materials,
Год журнала:
2024,
Номер
5(1)
Опубликована: Март 5, 2024
Abstract
Adverse
body
reactions
to
blood-contacting
medical
devices
endanger
patient
safety
and
impair
device
functionality,
with
events
invariably
linked
nonspecific
protein
adsorption
due
suboptimal
material
biocompatibility.
To
improve
the
durability
of
such
devices,
herein
we
propose
a
strategy
for
introducing
stable
zwitterionic
grafts
onto
polymeric
surfaces
via
plasma
functionalization.
The
resulting
zwitterion-grafted
substrates
exhibit
long-lasting
superhydrophilicity,
enabling
antifouling
anti-thrombogenic
properties.
We
demonstrate
successful
modification
surface
elemental
composition,
morphology,
hydrophilicity,
while
retaining
underlying
mechanical
properties
substrate.
Furthermore,
optimise
fabrication
process
ensure
modifications
at
least
three
months
after
fabrication.
This
decreases
fibrinogen
by
approximately
9-fold,
thrombosis
almost
75%
when
applied
commercial
polyurethane.
Moreover,
this
is
universally
applicable
wide
range
materials,
even
those
chemistry
as
polytetrafluoroethylene.
Global
plastic
pollution
in
oceans
and
estuaries
is
increasing
rapidly
it’s
well
known
that
bacteria
colonize
particles
of
all
sizes.
_Vibri_o
spp.
are
frequently
found
as
part
the
plastisphere.
We
recently
showed
_Vibrio
gazogenes_
DSM
21264
harbors
a
promiscuous
esterase
designated
PET6.
now
provide
evidence
_pet6_
gene
expressed
under
wide
range
environmental
conditions
its
native
host.
However,
PET-
PE-grown
biofilms
expression
was
not
affected
by
type
surface.
The
transcription
sufficient
to
allow
enzyme
production
release
µM
amounts
mono-(2-hydroxyethyl)
terephthalate
(MHET)
terephthalic
acid
(TPA)
already
after
24
hours
incubation
on
PET
foil.
Notably,
highest
observed
planktonic
lifestyle
presence
bis(2-hydroxyethyl)
(BHET)
one
primary
degradation
products
PET.
BHET
further
hydrolyzed
PET6
UlaG,
lactonase
had
been
be
involved
degradation.
Elevated
concentrations
major
signaling
circuits
bacterial
quorum
sensing
(QS),
c-di-GMP
cAMP-CRP
signaling.
This
resulted
failure
form
biofilms,
synthesis
red
pigment
prodigiosin
altered
colony
morphologies.
While
very
impact,
TPA
interfered
mainly
with
QS
attenuating
CAI-I
autoinducer
synthase
gene.
These
observations
imply
potential
role
nutritional
signals
may
affect
growth
survival
IMPORTANCE:
study
provides
first
secretes
an
active
hydrolase
degrades
polymer
using
when
growing
foils
microplastic
particles.
have
profound
impact
global
QS,
_V.
capability
marine
environment.
Surface
fouling
induced
by
biomolecules
and
microorganisms
remains
a
persistent
challenge
in
materials
science,
particularly
healthcare
applications,
where
biofilm
formation
on
medical
devices
may
lead
to
infections
antimicrobial
resistance.
Antifouling
strategies
typically
rely
the
of
either
hydration
layers
or
cytotoxic
for
direct
effects.
Recent
advances
zwitterionic
polymers
derived
from
ylides
offer
promising
yet
unexplored
toolbox
construction
antifouling
coatings.
While
N-oxide-based
have
been
extensively
studied
as
building
blocks
materials,
sulfur-ylide-based
precise
underlying
mechanisms
remain
underexplored
despite
their
broader
chemical
versatility.
Here,
we
present
fully
water-soluble
acrylamide-based
poly(sulfur
ylide)
compare
its
properties
those
previously
reported
hydrophobic
polystyrene-derived
analogues.
Notably,
ylides)
retain
efficacy
surfaces
but
lose
cytotoxicity
solution,
unlike
counterpart.
Computational
studies
reveal
that
dipole
moment
sulfur
is
environmentally
responsive,
stabilizing
environments.
Genetic
analysis
confirms
outer
membrane
destabilization
both
suggests
hydrophobicity
polystyrene
backbone
promotes
stronger
interactions.
We
suggest
future
work
should
focus
elucidating
additional
interactions,
including
supramolecular
behaviors
amphiphilic
ylides,
refine
structure–property
relationships
optimize
properties.
Grafted
polymeric
N-oxides
have
recently
attracted
interest
for
antifouling
applications,
drug
delivery,
wastewater
purification,
and
electronic
devices.
Their
function
depends
on
the
efficiency
of
grafting
process
following
postgrafting
oxidation
step.
These
two
parameters
govern
solvent-accessible
charge
density
surface,
an
important
parameter,
which
is
notoriously
hard
to
determine.
In
this
study,
a
novel
colorimetric
quantitative
assay
was
developed.
It
allows
determination
surface
grafted
N-oxides.
The
method
based
adsorption
acid
fuchsin
(AF)
through
reversible
electrostatic
interactions
between
positively
charged
nitrogen
atoms
N-oxide
functionality
sulfonate
groups
dye.
thus
pH-switchable
properties
Adsorption
achieved
at
pH
value
3,
where
are
almost
fully
protonated
(typical
pKa
4-5).
AF
desorbed
from
7
quantified
via
visible
spectroscopy
(UV-vis)
556
nm
determine
amount
surface-grafted
functional
groups.
Charge
densities
diverse
by
free
radical
polymerization
polyethylene
(PE)
were
determined
be
in
range
1-3
×
1015
N+-O-/cm2.
Notably,
can
form
covalent
bonds
with
electron-deficient
triarylmethane
dyes
like
AF.
This
nucleophilic
reactivity
does
not
compromise
proposed
assay,
but
it
may
relevance
dye
desorption
purification.
Macromolecular Bioscience,
Год журнала:
2024,
Номер
25(1)
Опубликована: Ноя. 8, 2024
Abstract
Protein
adhesion
and
thrombosis
formation
caused
by
limited
surface
properties
pose
great
challenges
to
biomedical
implants.
Although
various
hydrophilic
coating
or
drug
release
coatings
are
reported,
the
single
cannot
cope
with
cases
under
condition
of
complex
physiological
environment,
which
causes
effect
is
limited.
In
this
study,
a
polyamino
acid‐derived
zwitterionic
constructed
eliminate
reactive
oxygen
species
(ROS)
in
microenvironment.
It
demonstrated
that
has
excellent
hydrophilicity,
stability,
lubricity,
can
obviously
prevent
protein
adhesion.
At
same
time,
hydrogen
peroxide
maintain
stability
The
vivo
vitro
experiments
show
good
biocompatibility,
inhibits
thrombus.
Amino
acid
zwitterion
prevents
deposition,
alleviates
inflammatory
process,
inhibit
thrombosis,
reduces
risk
implantable
medical
devices,
prolongs
their
service
time.
Hence,
work
paves
new
way
develop
amino
based
polymer
reduce
implant
complications.