Dual-functional composite hydrogel platform: A “kill two birds with one stone” strategy for anti-infection and osseointegration in the treatment of infectious bone defects

Chemical Engineering Journal, Год журнала: 2024, Номер 498, С. 155337 - 155337

Опубликована: Сен. 1, 2024

Infectious bone defect (IBD), caused by various factors, frequently recur and are challenging to cure. Current treatments predominantly rely on a combination of antibiotics traditional surgery, yet they have not significantly reduced long-term recurrence rates. Given the complex microenvironment persistent mechanisms mediated bacteria, it is crucial for implants enhance osseointegration while ensuring sustained effective infection control. Hydrogels emerged as promising solution in tissue engineering due their excellent drug-loading efficiency, controlled drug release, adjustable mechanical strength, biocompatibility. Over past decade, hydrogels with dual anti-infection pro-osseointegration functions demonstrated efficacy treating IBD, making clinical application possible. This review summarizes current highlighting pros cons infection-mediated immune microenvironments. Additionally, discusses essential physicochemical properties suitable IBD reviews latest advancements dual-functional hydrogels. Finally, addresses future prospects, technical challenges, unresolved issues development Overall, this aims facilitate advancement implementation tailored therapeutic needs IBD.

Язык: Английский

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Development of Naphthalene-Derivative Bis-QACs as Potent Antimicrobials: Unraveling Structure–Activity Relationship and Microbiological Properties

Molecules, Год журнала: 2024, Номер 29(23), С. 5526 - 5526

Опубликована: Ноя. 22, 2024

While the pandemic is behind us, world community faces a global threat of bacterial resistance outbreak. One key ways to combat spread multi-resistant bacteria infection prevention and control tactics using modern antiseptic disinfectant compositions. Herein, we continue path unravel structure–activity relationship (SAR) potent pyridine-derived biocide class bis-quaternary ammonium compounds (QACs). In this study, twenty dihydroxynaphthalene-derivative bis-QACs were subjected extensive microbiological analysis on planktonic cells biofilms ESKAPE microorganisms. Among them, hit superior in their bacteriostatic bactericidal action commercial mono-QACs comparable best bis-QAC market. SAR indicated that linker conformation does not significantly affect activity, though structure symmetry especially lipophilicity had an influence antibacterial performance. Furthermore, delve deeper investigation antimicrobial potential conducted variety assays, including time–kill kinetics, formation, cell morphology, cytotoxicity. Studies showed promising results for 5d 6d, indicating 2 3-fold less cytotoxicity hemotoxicity compared QACs. Moreover, SEM imaging revealed can cause severe membrane damage S. aureus P. aeruginosa strains, confirming great novel as disinfectant.

Язык: Английский

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Naturally occurring compound as antibacterial agent to yield a Janus cotton fabric with durable antibacterial functionality and skin-friendly characteristics

Cellulose, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 26, 2024

Язык: Английский

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Bacterial inhibition and biofilm eradication ability of low-toxic deep eutectic solvents prepared from lactic acid and quaternary ammonium compounds

Materials Letters, Год журнала: 2024, Номер unknown, С. 137591 - 137591

Опубликована: Окт. 1, 2024

Язык: Английский

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Bifunctional catechol-based coating strategy to construct highly effective antimicrobial polyethylene microfibers for personal protective equipment

Progress in Organic Coatings, Год журнала: 2024, Номер 198, С. 108916 - 108916

Опубликована: Ноя. 18, 2024

Язык: Английский

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Biological and chemical properties of new multi-functional root canal irrigants

Journal of Dentistry, Год журнала: 2024, Номер unknown, С. 105551 - 105551

Опубликована: Дек. 1, 2024

Язык: Английский

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