A Nonswelling Hydrogel with Regenerable High Wet Tissue Adhesion for Bioelectronics

Advanced Materials, Год журнала: 2023, Номер 35(18)

Опубликована: Фев. 5, 2023

Reducing the swelling of tissue-adhesive hydrogels is crucial for maintaining stable tissue adhesion and inhibiting inflammation. However, reported strategies reducing always result in a simultaneous decrease adhesive strength hydrogel. Furthermore, once covalent bonds break currently hydrogels, they cannot be rebuilt, hydrogel loses its ability. In this work, nonswelling (named as "PAACP") possessing regenerable high synthesized by copolymerizing crosslinking poly(vinyl butyral) with acrylic acid, gelatin, chitosan-grafted N-acetyl-l-cysteine. The obtained PAACP reaches 211.4 kPa, which approximately ten times higher than that can reused multiple cycles. as-prepared shows great potential soft bioelectronics, muscle fatigue successfully monitored via electrode array strain sensor integrated on substrates. success these bioelectronics offers applicability long-term diagnosis muscle-related health conditions prosthetic manipulations.

Язык: Английский

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Tough, antifreezing, and conductive double network zwitterionic-based hydrogel for flexible sensors

Chemical Engineering Journal, Год журнала: 2022, Номер 452, С. 139314 - 139314

Опубликована: Сен. 19, 2022

Язык: Английский

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Current Understanding of Hydrogel for Drug Release and Tissue Engineering

Gels, Год журнала: 2022, Номер 8(5), С. 301 - 301

Опубликована: Май 15, 2022

Due to their good absorption, satisfactory biocompatibility, and high safety, hydrogels have been widely used in the field of biomedicine, including for drug delivery tissue regeneration. In this review, we introduce characteristics crosslinking methods natural synthetic hydrogels. Then, highlight design principle intelligent (i.e., responsive hydrogels) release. Moreover, application release engineering, limitations research directions hydrogel engineering are also considered. We hope that review can provide a reference follow-up studies related fields.

Язык: Английский

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Construction and characterization of highly stretchable ionic conductive hydrogels for flexible sensors with good anti-freezing performance

European Polymer Journal, Год журнала: 2023, Номер 186, С. 111827 - 111827

Опубликована: Янв. 9, 2023

Язык: Английский

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Triple Cross‐linked Dynamic Responsive Hydrogel Loaded with Selenium Nanoparticles for Modulating the Inflammatory Microenvironment via PI3K/Akt/NF‐κB and MAPK Signaling Pathways

Advanced Science, Год журнала: 2023, Номер 10(31)

Опубликована: Сен. 22, 2023

Modulating the inflammatory microenvironment can inhibit process of diseases (IDs). A tri-cross-linked microenvironment-responsive hydrogel with ideal mechanical properties achieves triggerable and sustained drug delivery regulates microenvironment. Here, this study develops an (OD-PP@SeNPs) composed phenylboronic acid grafted polylysine (PP), oxidized dextran (OD), selenium nanoparticles (SeNPs). The introduction SeNPs as initiators nano-fillers into results in extra cross-linking polymer network through hydrogen bonding. Based on Schiff base bonds, Phenylboronate ester a reactive oxygen species (ROS)/pH dual responsive triple-network is achieved. has injectable, self-healing, adhesion, outstanding flexibility, suitable swelling capacity, optimal biodegradability, excellent stimuli-responsive active substance release performance, prominent biocompatibility. Most importantly, ROS scavenging pH-regulating ability protects cells from oxidative stress induces macrophages M2 polarization to reduce cytokines PI3K/AKT/NF-κB MAPK pathways, exerting anti-inflammatory effects reshaping microenvironment, thereby effectively treating typical IDs, including S. aureus infected wound rheumatoid arthritis rats. In conclusion, dynamically injectable structure provides effective strategy treat holding great promise clinical application.

Язык: Английский

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Entanglement Added to Cross‐Linked Chains Enables Tough Gelatin‐Based Hydrogel for Zn Metal Batteries

Advanced Materials, Год журнала: 2024, Номер 36(30)

Опубликована: Май 15, 2024

Currently, it is still challenging to develop a hydrogel electrolyte matrix that can successfully achieve harmonious combination of mechanical strength, ionic conductivity, and interfacial adaptability. Herein, multi-networked with high entanglement effect based on gelatin/oxidized dextran/methacrylic anhydride, denoted as ODGelMA constructed. Attribute the Schiff base network formulation ─RC═N─, oxidized dextran integrated gelatin chains induce dense hydrophilic conformation group. Furthermore, addition methacrylic anhydride through grafting process, entangled achieves impressive features (6.8 MPa tensile strength) conductivity (3.68 mS cm

Язык: Английский

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Water: The soul of hydrogels

Progress in Materials Science, Год журнала: 2024, Номер unknown, С. 101378 - 101378

Опубликована: Сен. 1, 2024

Язык: Английский

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Tough, conductive hydrogels based on gelatin and oxidized sodium carboxymethyl cellulose as flexible sensors

Carbohydrate Polymers, Год журнала: 2024, Номер 335, С. 121920 - 121920

Опубликована: Фев. 9, 2024

Язык: Английский

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Black phosphorus boosts wet-tissue adhesion of composite patches by enhancing water absorption and mechanical properties

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Фев. 22, 2024

Abstract Wet-tissue adhesives have long been attractive materials for realizing complicated biomedical functions. However, the hydration film on wet tissues can generate a boundary, forming hydrogen bonds with that weaken adhesive strength. Introducing black phosphorus (BP) is believed to enhance water absorption capacity of tape-type and effectively eliminate layers between tissue adhesive. This study reports composite patch integrated BP nanosheets (CPB) wet-tissue adhesion. The patch’s improved mechanical properties ensure its immediate robust adhesion tissues. Various bioapplications CPB are demonstrated, such as rapid hemostasis (within ~1-2 seconds), monitoring physical-activity prevention tumour-recurrence, all validated via in vivo studies. Given good practicability, histocompatibility biodegradability CPB, proposed patches hold significant promise wide range applications.

Язык: Английский

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Bioinspired Freeze‐Tolerant Soft Materials: Design, Properties, and Applications

Small, Год журнала: 2022, Номер 18(37)

Опубликована: Авг. 15, 2022

Abstract In nature, many biological organisms have developed the exceptional antifreezing ability to survive in extremely cold environments. Inspired by freeze resistance of these organisms, researchers devoted extensive efforts develop advanced freeze‐tolerant soft materials and explore their potential applications diverse areas such as electronic skin, robotics, flexible energy, science. Herein, a comprehensive overview on recent advancement emerging from perspective bioinspiration material engineering is provided. First, mechanisms underlying tolerance cold‐enduring are introduced. Then, strategies for developing summarized. Thereafter, advances different technological smart sensors actuators, energy harvesting storage, cryogenic medical presented. Finally, future challenges opportunities rapid development bioinspired discussed.

Язык: Английский

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