Functionalized Carbon Nanotubes: Emerging Nanomaterials for Enhanced Cancer Diagnosis and Imaging

Molecules, Год журнала: 2025, Номер 30(11), С. 2364 - 2364

Опубликована: Май 29, 2025

Cancer remains a leading global cause of mortality, highlighting the critical need for effective early diagnosis. Despite advancements in treatment, detection and imaging continue to pose significant challenges. Functionalized carbon nanotubes (CNTs) have emerged as promising nanomaterials due their unique structural properties versatile functionalization strategies. This review explores role both covalent (e.g., fluorination, hydrogenation, cycloadditions, aryldiazonium salt reduction, organometallic ion attachment, carboxylation, amidation, esterification, metallic nanoparticle attachments) non-covalent methods surfactant coating, polymer wrapping, biomolecule encapsulation) enhancing CNT biocompatibility diagnostic efficiency. CNTs are extensively applied cancer through highly sensitive biosensors, including electrochemical, optical, field-effect transistor-based systems, capable detecting various biomarkers with exceptional sensitivity. Additionally, they offer advantages modalities such fluorescence imaging, magnetic resonance (MRI), computed tomography (CT), ultrasound improving contrast, resolution, specificity. also discusses challenges future directions development CNT-based platforms, emphasizing continued research advance clinical translation integration into routine diagnostics.

Язык: Английский

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An Augmented Reality Visor for Intraoperative Visualization, Guidance, and Temperature Monitoring Using Fluorescence

Journal of Biophotonics, Год журнала: 2024, Номер unknown

Опубликована: Дек. 23, 2024

ABSTRACT Fluorescence‐guided surgeries, including tumor resection and tissue soldering, are advancing the frontiers of surgical precision by offering enhanced control that minimizes damage, improving recovery outcomes. However, integrating fluorescence visualization with real‐time temperature monitoring remains a challenge, limiting broader clinical use. We address this issue an augmented reality (AR) visor combines nanomaterial excitation, detection, monitoring. Using advanced fluorescent nanoparticles like indocyanine green‐doped particles carbon nanotubes, provides comprehensive view both field sub‐surface conditions invisible to naked eye. This integration improves safety efficacy fluorescence‐guided laser ensuring optimal temperatures guidance in real time. The presented technology enhances existing techniques supports development new strategies sensing technologies areas where traditional methods fall short, marking significant progress surgery potentially patient care.

Язык: Английский

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An Augmented Reality Visor for Intraoperative Visualization, Guidance and Temperature Monitoring using Fluorescence

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 9, 2024

Fluorescence-guided surgical techniques, including tumor resection and tissue soldering, are advancing the frontiers of precision by offering enhanced control that minimizes damage improves recovery as well outcomes. However, integrating visualization fluorescent signal temperature monitoring seamlessly into workflows has not been fully realized remains a challenge, thus limiting their effectiveness wide-spread clinical adoption. To address this issue, we introduce an augmented reality (AR) visor designed to unite nanomaterial excitation along with fluorescence detection, during procedures. The AR was evaluated using advanced nanoparticles, such indocyanine green-doped particles single-walled carbon nanotubes. By consolidating visualization, monitoring, precise single platform, equip surgeons comprehensive view both field sub-surface conditions invisible naked eye. This integration notably safety efficacy fluorescence-guided surgeries, emerging technologies laser ensuring soldering stays within therapeutic thresholds is accurately guided real-time signals. presented technology only enhances existing techniques but also supports development new strategies sensing in areas where traditional methods fall short, marking significant progress surgery, which could ultimately improve patient care.

Язык: Английский

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