Applied Physics Reviews,
Год журнала:
2023,
Номер
10(4)
Опубликована: Ноя. 8, 2023
The
early
detection
of
tumors
and
precancerous
conditions
is
vital
for
cancer
diagnosis.
Advances
in
fluorescence
microscopic
techniques
materials
synthesis
processes
have
revolutionized
biomarker
image-guided
surveillance.
In
particular,
novel
materials-based
diagnostic
tools
innovative
therapies
facilitated
a
precise
understanding
biological
at
the
molecular
level.
This
critical
review
presents
an
overview
bioimaging
probes,
including
functionalized
chromophoric
systems,
non-functionalized
nanoscale
biosensors.
Technical
challenges
future
directions
related
to
these
approaches
are
considered.
ACS Nano,
Год журнала:
2023,
Номер
17(23), С. 23430 - 23441
Опубликована: Ноя. 27, 2023
The
mechanisms
of
action
(MoA)
have
been
proposed
to
further
reduce
the
O2
dependence
photodynamic
therapy
(PDT)
significantly.
However,
triplet
states
traditional
photosensitizers
are
relatively
short
and
also
easily
deactivated
by
quenching
H2O
or
O2.
This
is
not
conducive
for
electron
transfer
in
photocatalytic
process
poses
a
great
obstacle
establish
MoA.
Therefore,
we
selected
synthesized
zirconium(IV)
complex
(Zr(MesPDPPh)2)
reported
Milsmann
address
this
issue.
specific
symmetric
intact
geometry
endowed
Zr(MesPDPPh)2
NPs
with
long-lived
excited
state
(τ
=
350
μs),
desired
sensitized
ability,
improved
anti-interfering
performance
on
O2,
which
was
matched
requirements
photoredox
catalyst
results
showed
that
while
PDT
(I)
(II)
could
be
achieved
simultaneously
leveraging
NPs,
it
served
as
rare
example
thermally
activated
delayed
fluorescence
(TADF)-based
implement
MoA
PDT.
It
involved
oxidation
NADH
establishment
catalytic
cycle
collaborating
cytochrome
c
(cyt
c)
normoxia
hypoxia,
respectively.
As
result,
oxygen-free
tumor-growth
inhibition
realized.
European Journal of Inorganic Chemistry,
Год журнала:
2023,
Номер
26(36)
Опубликована: Окт. 12, 2023
Abstract
Luminescent
Cu
I
complexes
have
attracted
significant
interest
due
to
their
adjustable
emission
properties,
diverse
structures,
and
reasonable
cost.
In
this
work,
two
class
of
complexes,
namely
phosphinine
pyridine
ligated
that
differ
by
only
one
atom,
were
synthesized
characterized.
Photophysical
analysis
theoretical
studies
reveal
an
emissive
phosphinine‐localized
triplet
states
for
a
temperature‐dependent
interplay
between
metal‐to‐ligand
charge‐transfer
(MLCT)
singlet
complexes.
general,
the
exhibit
longer
lifetime
greater
changes
than
A
molecular
thermometer
incorporating
2
c
as
indicator
was
fabricated.
This
exhibits
rare
linear
correlation
temperature
ranging
from
77–297
K
with
high
sensitivity
−13.5
μs
−1
.
Angewandte Chemie,
Год журнала:
2024,
Номер
136(17)
Опубликована: Март 5, 2024
Abstract
By
combining
bioimaging
and
photodynamic
therapy
(PDT),
it
is
possible
to
treat
cancer
through
a
theranostic
approach
with
targeted
action
for
minimum
invasiveness
side
effects.
Thermally
activated
delayed
fluorescence
(TADF)
probes
have
gained
recent
interest
in
theranostics
due
their
ability
generate
singlet
oxygen
(
1
O
2
)
while
providing
emission
that
can
be
used
time‐gated
imaging.
However,
still
challenging
design
systems
simultaneously
show
(1)
high
contrast
imaging,
(2)
low
dark
toxicity
but
phototoxicity
(3)
tunable
biological
uptake.
Here,
we
circumvent
shortcomings
of
TADF
by
designing
block
copolymers
corresponding
semiconducting
polymer
dots
(Pdots)
encapsulate
dye
the
core
expose
an
additional
boron‐dipyrromethene
(BODIPY)
sensitizer
corona.
This
architecture
provides
orange‐red
luminescent
particles
(Φ
PL
up
18
%)
efficiently
promote
PDT
QY=42
HeLa
cells
very
photosensitizer
loading
(IC
50
~0.05–0.13
μg/mL
after
30
min).
Additionally,
Pdots
cellular
uptake
similar
efficiencies
using
either
polyethylene
glycol
or
guanidinium‐based
coronas.
Finally,
demonstrate
these
imaging
effectively
filter
out
background
from
samples
improve
image
contrast.
