Design and Construction of Photosensitizers for Photodynamic Therapy of Tumor
Опубликована: Янв. 3, 2025
In
this
chapter,
we
describe
the
therapeutic
principles
of
photodynamic
therapy
(PDT)
and
its
advantages
disadvantages
compared
with
conventional
treatments.
Then,
influencing
factors
PDT
efficiency
are
discussed.
To
improve
PDT,
it
is
crucial
to
develop
optimize
photosensitizers.
Subsequently,
introduce
various
types
photosensitizers
in
sequence,
including
organic
molecules,
metal
complexes,
frameworks,
carbon
nanomaterials,
silicon-based
materials,
simple
substances,
oxides,
lanthanide
upconversion
nanoparticles-based
Notable
recent
studies
selected
illustrate
design
concept
logic,
as
well
key
mechanisms
tumor
treatment.
We
present
guidelines
examples
developed
aid
future
photosensitizer
development.
These
address
issues
such
low
yield
reactive
oxygen
species,
insufficient
accumulation
photosensitizer,
shallow
penetration
depth
light,
inability
single
effectively
inhibit
growth.
Finally,
recommendations
insights
for
advancement
prompted.
Язык: Английский
Harnessing Photo‐Energy Conversion in Nanomaterials for Precision Theranostics
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 16, 2025
Abstract
The
rapidly
advancing
field
of
theranostics
aims
to
integrate
therapeutic
and
diagnostic
functionalities
into
a
single
platform
for
precision
medicine,
enabling
the
simultaneous
treatment
monitoring
diseases.
Photo‐energy
conversion‐based
nanomaterials
have
emerged
as
versatile
that
utilizes
unique
properties
light
activate
with
high
spatial
temporal
precision.
This
review
provides
comprehensive
overview
recent
developments
in
photo‐energy
conversion
using
nanomaterials,
highlighting
their
applications
disease
theranostics.
discussion
begins
by
exploring
fundamental
principles
including
types
materials
used
various
light‐triggered
mechanisms,
such
photoluminescence,
photothermal,
photoelectric,
photoacoustic,
photo‐triggered
SERS,
photodynamic
processes.
Following
this,
delves
broad
spectrum
emphasizing
role
diagnosis
major
diseases,
cancer,
neurodegenerative
disorders,
retinal
degeneration,
osteoarthritis.
Finally,
challenges
opportunities
technologies
are
discussed,
aiming
advance
personalized
medicine.
Язык: Английский
Liquid metal-based stretchable bioelectronic fiber for electrical stimulation and drug delivery in minimally invasive cardiac therapy
APL Bioengineering,
Год журнала:
2025,
Номер
9(2)
Опубликована: Май 20, 2025
Cardiovascular
diseases,
such
as
ventricular
arrhythmias
and
heart
failure,
require
timely
effective
treatment
to
prevent
disease
progression
improve
patient
outcomes.
Current
therapeutics,
including
electrical
shock
emergent
cardiovascular
medications,
have
significantly
contributed
managing
these
conditions.
However,
due
their
systemic
side
effects,
there
are
ongoing
demands
for
highly
localized
therapies.
In
this
regard,
a
soft
implantable
device
has
been
considered
cardiac
applications,
but
invasiveness
in
implantation
procedure
difficulty
compact
integration
of
multiple
functions
unmet
challenges.
To
address
issues,
we
develop
stretchable,
multi-functional
fiber
designed
intervention,
offering
electrogram
recording,
modulation,
drug
therapy
directly
at
the
epicardial
surface.
With
temperature-dependent
phase
shifting
properties
liquid
metal
inside
fiber,
stiffened
can
be
implanted
into
thoracic
cavity
without
invasive
surgery.
Once
implanted,
softened
provides
multimodal
therapies
(e.g.,
chemotherapy
therapy)
tailored
patient's
condition.
By
tuning
delivery
parameters
based
on
continuous
urgent
interventions
severe
demonstrated
an
vivo
rat
model.
Язык: Английский
Insertable Biosensors: Combining Implanted Sensing Materials with Wearable Monitors
Annual Review of Biomedical Engineering,
Год журнала:
2024,
Номер
26(1), С. 197 - 221
Опубликована: Фев. 12, 2024
Insertable
biosensor
systems
are
medical
diagnostic
devices
with
two
primary
components:
an
implantable
within
the
body
and
a
wearable
monitor
that
can
remotely
interrogate
from
outside
body.
Because
does
not
require
physical
connection
to
electronic
monitor,
insertable
promise
improved
patient
comfort,
reduced
inflammation
infection
risk,
extended
operational
lifetimes
relative
established
percutaneous
systems.
However,
lack
of
also
presents
technical
challenges
have
necessitated
new
innovations
in
developing
sensing
chemistries,
transduction
methods,
communication
modalities.
In
this
review,
we
discuss
key
developments
made
insertables
promising
option
for
longitudinal
biometric
monitoring
highlight
essential
needs
existing
development
realizing
next
generation
extended-use
prognostic
devices.
Язык: Английский
Influence of Host Lattice Ions on the Dynamics of Transient Multiband Upconversion in Yb–Er Codoped NaLnF4 and LiLnF4 Microcrystals (Ln: Y, Lu, Gd)
ACS Omega,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 10, 2024
Inorganic
host
matrices
provide
a
tunable
luminescence
environment
for
lanthanide
ions,
allowing
the
modulation
of
upconversion
(UCL)
properties.
AREF
Язык: Английский
Battery-Free Optoelectronic Patch for Photodynamic and Light Therapies in Treating Bacteria-Infected Wounds
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Дек. 14, 2023
Abstract
Light
therapy
is
an
effective
approach
for
the
treatment
of
a
variety
challenging
dermatological
conditions.
In
contrast
to
existing
methods
involving
high
doses
and
large
areas
illumination,
alternative
strategies
based
on
wearable
designs
that
utilize
low
light
dose
over
extended
period
provide
precise
convenient
treatment.
this
study,
we
present
battery-free,
skin-integrated
optoelectronic
patch
incorporates
coil-powered
circuit,
array
microscale
violet
red
emitting
diodes
(LEDs),
polymer
microneedles
(MNs)
loaded
with
5-aminolevulinic
acid
(5-ALA).
This
MNs,
biodegradable
composite
materials
polyvinyl
alcohol
(PVA)
hyaluronic
(HA),
serves
as
waveguides
optical
access
medium
drug
release
into
deeper
skin
layers.
Unlike
conventional
clinical
photomedical
appliances
rigid
fixed
source,
flexible
design
allows
conformable
source
can
be
applied
directly
skin.
animal
models
bacterial-infected
wounds,
experimental
group
combination
metronomic
photodynamic
therapies
reduced
2.48
log
10
CFU
mL
−1
in
bactericidal
level
compared
control
group,
indicating
anti-infective
response.
Furthermore,
post-treatment
analysis
revealed
activation
proregenerative
genes
monocyte
macrophage
cell
populations,
suggesting
enhanced
tissue
regeneration,
neovascularization,
dermal
recovery.
Overall,
broadens
scope
targeting
deep
lesions,
provides
functionality
standard
methods.
Язык: Английский