Organic Letters,
Год журнала:
2021,
Номер
23(19), С. 7650 - 7655
Опубликована: Сен. 16, 2021
A
mild
and
chemoselective
three-component
thioesterification
using
olefins,
α-ketoacids,
elemental
sulfur
has
been
developed.
The
photocatalytic
activation
of
sulfur,
a
cheap
abundant
source,
enables
the
rapid
installation
atom
into
molecules,
reactions
that
ordinarily
would
require
use
reactive
malodorous
sulfur-containing
compounds
such
as
thiols
thioacids.
This
novel
reaction
is
characterized
by
high
yields
broad
substrate
scope,
which
introduction
thioester
moieties
complex
molecules
including
steroid,
peptide,
nonprotected
glycoside.
Mechanistic
studies
indicated
success
this
transformation
depends
on
multiple
roles
played
those
sulfurizing
agent,
terminal
oxidant,
HAT
mediator.
ACS Sustainable Chemistry & Engineering,
Год журнала:
2022,
Номер
10(2), С. 671 - 677
Опубликована: Янв. 3, 2022
Sulfur-containing
molecules
are
increasingly
crucial
in
chemistry-related
fields
and
widely
applied
life
science,
material
food
pharmaceutical
science.
This
perspective
focuses
on
the
introduction
of
green
sulfurizing
reagents
sustainable
methodologies
to
realize
diverse
kinds
functionalized
transformations
synthetic
applications.
The
text
is
organized
according
structure
sulfur-containing
corresponding
method.
It
expected
be
interest
organic
chemistry
professionals
who
wish
better
understand
insights
applications
organosulfur
transformations.
Coordination Chemistry Reviews,
Год журнала:
2022,
Номер
464, С. 214556 - 214556
Опубликована: Апрель 13, 2022
The
chalcogen
bond
(ChB)
is
defined
as
a
noncovalent
interaction
between
the
electron
density
deficient
region
(so-called
σ
or
π
hole)
of
covalently
bonded
atom
and
nucleophilic
(Nu)
site
in
same
(intramolecular)
another
(intermolecular)
molecular
entity:
R–Ch⋯Nu
[Ch
=
O,
S,
Se
Te;
R
C,
Pn
(pnictogen),
Ch,
metal,
etc.;
Nu
lone
pair
possessing
Ha,
metal
atom,
π-system,
anion,
radical,
etc.].
Like
halogen
(Ha)
pnictogen
(Pn)
bonds,
parameters
(strength,
high
directionality
tunability)
make
ChB
relevant
supramolecular
tool
design
secondary
coordination
sphere
complexes,
which
concerns
an
important
synthetic
strategy
improvement
functional
properties
materials.
In
this
review
we
discuss/illustrate
several
examples,
taken
from
Cambridge
Structural
Database,
plays
crucial
role
decoration
compounds,
controlling
conformation,
packing
aggregation
tectons,
well
formation
0D
aggregates,
1D
chains,
2D
layers,
3D
frameworks,
etc.
Proceedings of the National Academy of Sciences,
Год журнала:
2024,
Номер
121(11)
Опубликована: Март 4, 2024
Lipid
nanoparticles
(LNPs)
largely
rely
on
ionizable
lipids
to
yield
successful
nucleic
acid
delivery
via
electrostatic
disruption
of
the
endosomal
membrane.
Here,
we
report
identification
and
evaluation
containing
a
thiophene
moiety
(Thio-lipids).
The
Thio-lipids
can
be
readily
synthesized
Gewald
reaction,
allowing
for
modular
lipid
design
with
functional
constituents
at
various
positions
ring.
Through
rational
structure,
prepared
47
identified
some
structural
criteria
required
in
efficient
mRNA
(messenger
RNA)
encapsulation
vitro
vivo.
Notably,
none
tested
have
pH-response
profile
like
traditional
lipids,
potentially
due
electron
delocalization
core.
Placement
tails
localization
headgroup
core
endow
capability
reach
tissues.
Using
high-throughput
formulation
barcoding
techniques,
optimized
formulations
select
two
top
lipids—
20b
29d
—and
investigated
their
biodistribution
mice.
enabled
LNPs
transfect
liver
spleen,
LNP
transfected
lung
spleen.
Unexpectedly,
was
especially
potent
retina
no
acute
toxicity,
leading
photoreceptors
retinal
pigment
epithelium
non-human
primates.
ACS Catalysis,
Год журнала:
2024,
Номер
14(9), С. 6973 - 6980
Опубликована: Апрель 19, 2024
Development
of
photocatalytic
systems
that
facilitate
mechanistically
divergent
steps
in
complex
catalytic
manifolds
by
distinct
activation
modes
can
enable
previously
inaccessible
synthetic
transformations.
However,
multimodal
remain
understudied,
impeding
their
implementation
methodology.
We
report
herein
a
access
to
thiols
directly
merges
the
structural
diversity
carboxylic
acids
with
ready
availability
elemental
sulfur
without
substrate
preactivation.
The
transformation
provides
direct
radical-mediated
segue
one
most
biologically
important
and
synthetically
versatile
organosulfur
functionalities,
whose
accessibility
remains
largely
dominated
two-electron-mediated
processes
based
on
toxic
uneconomical
reagents
precursors.
two-phase
radical
process
is
facilitated
reactivity
acridine
photocatalysis
enables
both
singlet
excited
state
PCET-mediated
decarboxylative
carbon–sulfur
bond
formation
unknown
reductive
disulfur
cleavage
photoinduced
hydrogen
atom
transfer
silane–triplet
system.
study
points
significant
potential
providing
unexplored
directions
Organic Letters,
Год журнала:
2024,
Номер
26(8), С. 1589 - 1594
Опубликована: Фев. 22, 2024
This
study
demonstrates
a
highly
efficient
regiodivergent
ligand-controlled
palladium-catalyzed
cycloaddition
reaction
of
vinyloxazolidine-2,4-diones
with
1,3,5-triazinanes.
In
the
presence
diphosphine
ligand,
proceeds
via
(5+2)
pathway
to
afford
1,3-diazepin-4-ones
in
excellent
yields,
while
using
monophosphine
smoothly
(3+2)
give
imidazolidin-4-ones
good
yields.
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
63(8)
Опубликована: Янв. 3, 2024
Abstract
The
bulk
radical
polymerization
of
bis(aziridine)
with
molten
elemental
sulfur
resulted
in
brittle,
cross‐linked
polymers.
However,
when
the
was
treated
presence
an
organobase,
ring‐opening
reaction
aziridine
oligosulfide
anions
occurred,
leading
to
formation
linear
polymers
by
step‐growth
polymerization.
These
newly
synthesized
possess
repeating
units
containing
a
sulfonamide
or
amide
functional
moiety
and
bonds
average
segment
about
two.
A
small
molecular
model
confirmed
nucleophilic
addition
aziridine.
It
verified
that
S−S
dynamic
bond
exchange
takes
place
organic
base
within
chains.
mixture
polysulfides
pyridine
exhibits
exceptional
adhesive
properties
applied
steel,
aluminum
substrates.
Notably,
these
prepared
adhesives
displayed
good
reusability
due
complete
recyclability
their
solution
processability.
This
sulfur‐involved
approach
represents
innovative
method
for
synthesis
advanced
sulfur‐containing
polymers,
demonstrating
potential
various
applications
beyond.
Asian Journal of Organic Chemistry,
Год журнала:
2024,
Номер
13(3)
Опубликована: Янв. 27, 2024
Abstract
Thiophene,
as
an
important
sulfur‐containing
heterocyclic,
is
widely
used
in
pharmaceuticals,
functional
materials,
and
natural
products.
Furthermore,
thiophene
of
great
interest
to
synthetic
chemists
due
its
diverse
reactivities.
Over
the
past
few
decades,
many
strategies
are
developed
for
functionalized
thiophenes.
Several
reviews
have
been
reported.
However,
there
no
review
on
synthesis
summarized
based
sulfur
sources.
The
current
envisioned
summary
methods
with
respect
sources
give
support
choose
appropriate
tools
obtain
substrates.
RSC Mechanochemistry,
Год журнала:
2024,
Номер
1(1), С. 38 - 42
Опубликована: Янв. 1, 2024
α-Ketothioamides
are
formed
by
a
mechanochemical
solvent-free
Willgeroth–Kindler-type
reaction
starting
from
acetophenone
derivatives,
amines,
and
elemental
sulfur.
