Chinese Journal of Organic Chemistry,
Год журнала:
2023,
Номер
43(9), С. 3006 - 3006
Опубликована: Янв. 1, 2023
As
one
of
the
most
important
structural
motifs
in
natural
compounds
and
active
pharmaceutical
ingredients,
azaspiro[4.5]trienonesderivatives
have
been
widely
used
field
organic
synthesis
due
to
their
excellent
properties
biological
activities.In
recent
years,
several
methods,
such
as
transition
metal
involvement,
visible
light
promotion,
metal-free
involvement
electrochemical
efficiently
construct
various
functional
groups
azaspiro[4.5]trienones.The
advances
azaspiro[4.5]trienones
are
reviewed,
representative
substrates
reaction
mechanisms
summarized
discussed.
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
We
report
an
efficient
photocatalytic
protocol
for
the
defluorocyanoalkylation
and
defluoroacylation
of
α-trifluoromethyl
styrenes
by
utilizing
oxime
esters
as
radical
donors,
allowing
preparation
diverse
Organic & Biomolecular Chemistry,
Год журнала:
2021,
Номер
19(47), С. 10348 - 10358
Опубликована: Янв. 1, 2021
A
practical
synthetic
route
to
construct
a
variety
of
3-benzyl
spiro[4,5]trienones
was
developed
via
transition-metal
Cu/Ag-catalyzed
oxidative
ipso-annulation
activated
alkynes
with
unactivated
toluenes
using
TBPB
as
an
oxidant
under
microwave
irradiation.
This
method
allows
the
formation
two
carbon-carbon
bonds
and
one
carbon-oxygen
bond
in
single
reaction
through
sequence
C-H
coupling,
ipso-carbocyclization
dearomatization.
The
advantages
this
protocol
are
its
operational
simplicity
broad
substrate
scope,
ability
afford
desired
products
moderate
good
yields.
Synthesis,
Год журнала:
2022,
Номер
54(13), С. 3105 - 3113
Опубликована: Фев. 17, 2022
Abstract
A
blue
LED-promoted
dearomative
oxo-spirocyclization
of
N-aryl-N-(2-hydroxyethyl)propiolamides
is
developed.
The
reaction
works
well
to
provide
a
series
selenium-containing
benzo[b]pyrrolo[2,1-c][1,4]oxazine-3,9-diones
with
high
efficiency
and
good
tolerance
for
functional
groups.
Besides,
diselenium-containing
can
also
be
efficiently
synthesized
in
the
presence
Oxone.
In
this
process,
it
believed
that
selenium
radical-triggered
ipso-cyclization
oxo-Michael
addition
are
involved.
Further
applications
using
prepared
products
bioactivity
assay
currently
underway.
European Journal of Organic Chemistry,
Год журнала:
2022,
Номер
2022(35)
Опубликована: Авг. 12, 2022
Abstract
A
new
photoinduced
acylation/arylation
of
N
‐(arylsulfonyl)acrylamide
with
acyl
oxime
esters
through
a
nitrogen‐centered
radical
protocol
has
been
disclosed
for
efficient
preparation
functionalized
indolin‐2‐ones,
which
proceeds
cascade
addition
carbon‐carbon
double
bond,
aryl
migration,
desulfonylation,
and
intramolecular
cyclization
sequence.
This
redox‐neutral
strategy
features
excellent
selectivity,
good
substituent
tolerance,
wide
substrate
scope.
Chinese Journal of Organic Chemistry,
Год журнала:
2023,
Номер
43(9), С. 3006 - 3006
Опубликована: Янв. 1, 2023
As
one
of
the
most
important
structural
motifs
in
natural
compounds
and
active
pharmaceutical
ingredients,
azaspiro[4.5]trienonesderivatives
have
been
widely
used
field
organic
synthesis
due
to
their
excellent
properties
biological
activities.In
recent
years,
several
methods,
such
as
transition
metal
involvement,
visible
light
promotion,
metal-free
involvement
electrochemical
efficiently
construct
various
functional
groups
azaspiro[4.5]trienones.The
advances
azaspiro[4.5]trienones
are
reviewed,
representative
substrates
reaction
mechanisms
summarized
discussed.
