Progress in heterocyclic chemistry, Год журнала: 2023, Номер unknown, С. 281 - 332
Опубликована: Янв. 1, 2023
Язык: Английский
Progress in heterocyclic chemistry, Год журнала: 2023, Номер unknown, С. 281 - 332
Опубликована: Янв. 1, 2023
Язык: Английский
ChemistrySelect, Год журнала: 2024, Номер 9(18)
Опубликована: Май 6, 2024
Abstract Multicomponent reactions are operationally simple and display a significant role in diverse chemical modification by reducing reaction times as well additional steps involved. In this review, we highlighted the impact of multi‐component assistance with modular Click chemistry to develop library triazole‐appended scaffolds including 1,2,3‐triazole‐fused heterocycles, glycoconjugates, macrocycles combinatorial synthesis differently functionalized triazoles along mechanistic insights range applications field medicinal chemistry.
Язык: Английский
Процитировано
9Current Opinion in Green and Sustainable Chemistry, Год журнала: 2023, Номер 40, С. 100756 - 100756
Опубликована: Янв. 14, 2023
Язык: Английский
Процитировано
12Organic Letters, Год журнала: 2023, Номер 25(26), С. 4770 - 4775
Опубликована: Июнь 26, 2023
A novel Ru-catalyzed redox-neutral [4+2] cyclization of 2-arylbenzimidazoles with α-trifluoromethyl-α-diazoketones has been achieved through sequential C-H activation and defluorinative annulation. This synthetic protocol unlocks modular expeditious access to 6-fluorobenzimidazo[2,1-a]isoquinolines high efficiency excellent functional group compatibility. The resultant monofluorinated heterocyclic products can readily diversified by various nucleophiles.
Язык: Английский
Процитировано
11Asian Journal of Organic Chemistry, Год журнала: 2023, Номер 12(9)
Опубликована: Июль 29, 2023
Abstract Multicomponent reactions (MCRs) have emerged as powerful tools in synthetic chemistry for the efficient synthesis of diverse molecular scaffolds, particularly nitrogen‐containing heterocycles. Despite their numerous advantages, use transition metal catalysts or additives MCRs can present limitations due to cost, toxicity, and environmental concerns. In recent years, there has been a growing interest metal‐free N ‐heterocyclic compounds. This review provides comprehensive concise overview advancements valuable ‐heterocycles over past five years. The is systematically organized, categorizing discussed based on size heterocyclic ring number nitrogen atoms. Only that result formation rings containing at least one atom are included, while derivatization using falls outside scope this review. By highlighting developments field, aims showcase potential significance sustainable strategies accessing elimination metals not only simplifies reaction conditions but also contributes greener more environmentally friendly approaches. serves resource researchers interested design application
Язык: Английский
Процитировано
11Asian Journal of Organic Chemistry, Год журнала: 2023, Номер 12(5)
Опубликована: Март 23, 2023
Abstract A copper‐catalyzed [3+2] annulation of the in situ generated pyridinium ylides with α‐CF 3 ketones was realized, which first acted as synthetic equivalents unstable fluoroalkynones. With this protocol, a series functionalized 2‐fluoroindolizines were afforded moderate to good yields under ambient conditions air oxidant.
Язык: Английский
Процитировано
9Organic Letters, Год журнала: 2023, Номер 25(34), С. 6368 - 6373
Опубликована: Авг. 18, 2023
A chemo-, regio-, and stereoselective reaction of trifluoromethyl enones, phenylsilane, phosphine oxides through a sequential hydrodefluorination defluorophosphorylation relay is developed for the synthesis distinctive gem-fluorophosphine alkenes. This multicomponent occurred under transition-metal-free conditions with good functional group tolerance. Moreover, preinstalled carbonyl auxiliary important tuning reactivity β-trifluoromethyl thereby enabling controllable selective functionalization two fluorine atoms in trifluoromethylated enones.
Язык: Английский
Процитировано
9Chinese Journal of Organic Chemistry, Год журнала: 2025, Номер 45(1), С. 86 - 86
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0The Journal of Organic Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Март 29, 2025
This paper describes a NaPHI-catalyzed oxytrifluoromethylation of olefins under photoirradiation. The reaction is applicable for the synthesis α-trifluoromethyl ketones, which could be structurally elaborated into an array useful scaffolds. Mechanistic studies suggested that photoexcited NaPHI* facilitate formation singlet 1O2 through EnT process, thus enabling difunctionalization with trifluoromethyl radical and oxygen anion species.
Язык: Английский
Процитировано
0New Journal of Chemistry, Год журнала: 2023, Номер 47(13), С. 6171 - 6175
Опубликована: Янв. 1, 2023
A new and practical cyanation of α-CF 3 carbonyls with aqueous ammonia is developed.
Язык: Английский
Процитировано
8The Journal of Organic Chemistry, Год журнала: 2023, Номер 88(14), С. 10137 - 10146
Опубликована: Июль 12, 2023
An efficient and selective transformation of 2,2,2-trifluoroethyl carbonyls into ureas/amides with amines is reported. This protocol allows the cleavage C–C bond under transition metal-free oxidant-free conditions, which in contrast to analogous C–F or C–CF3 functionalization. reaction reveals unexplored reactivity exhibits a broad substrate range good functional group tolerance.
Язык: Английский
Процитировано
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