Chemistry - An Asian Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 29, 2024
A
novel
protocol
for
the
visible-light-driven
synthesis
of
β-trifluoromethylated
enamines
has
been
developed,
which
operates
without
use
transition
metals
or
any
photocatalysts,
utilizing
trifluoromethylthiosulfonium
salts
as
source
trifluoromethyl
groups
under
mild
conditions.
According
to
this
new
protocol,
more
than
40
products
have
prepared
in
moderate
good
yields.
In
addition
eliminating
need
expensive
toxic
and
methodology
proves
its
potential
scalability
through
air-stability,
safe
readily
available
reagents,
a
two-step
one-pot
procedure,
effective
gram-scale
reactions.
This
innovative
approach
not
only
demonstrates
promise
green
chemical
but
also
offers
pathway
advancement
fluorine
chemistry
sustainable
organic
synthesis.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(12), С. 2715 - 2720
Опубликована: Май 9, 2024
Abstract
A
one‐pot
multi‐component
reaction
strategy
for
the
selective
synthesis
of
5‐trifluoromethyl
pyrimidine
derivatives
has
been
established.
This
method
avoids
inherent
selectivity
challenges
in
direct
trifluoromethylation.
The
demonstrates
tolerance
to
various
functional
groups,
yielding
with
up
80%
yields.
Moreover,
practicality
this
underscored
through
scale‐up
reactions.
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(21), С. 4399 - 4403
Опубликована: Июль 16, 2024
Abstract
A
multicomponent
cascade
cyclization
reaction
using
aryl
methyl
ketones,
amines,
and
enaminamide
reagents
to
construct
3‐hydroxy‐1
H
‐pyrrolo[3,4‐
b
]quinolin‐1‐one
skeleton
with
good
substrate
compatibility
(50
examples)
has
been
reported.
The
one‐pot,
metal‐free
process
formed
two
C−C
bonds,
C−N
a
tetrasubstituted
carbon
stereocenter
containing
hydroxyl
group.
enabled
modified
transformation
of
drug
molecules
derivatization
products.
Chemistry - An Asian Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 29, 2024
A
novel
protocol
for
the
visible-light-driven
synthesis
of
β-trifluoromethylated
enamines
has
been
developed,
which
operates
without
use
transition
metals
or
any
photocatalysts,
utilizing
trifluoromethylthiosulfonium
salts
as
source
trifluoromethyl
groups
under
mild
conditions.
According
to
this
new
protocol,
more
than
40
products
have
prepared
in
moderate
good
yields.
In
addition
eliminating
need
expensive
toxic
and
methodology
proves
its
potential
scalability
through
air-stability,
safe
readily
available
reagents,
a
two-step
one-pot
procedure,
effective
gram-scale
reactions.
This
innovative
approach
not
only
demonstrates
promise
green
chemical
but
also
offers
pathway
advancement
fluorine
chemistry
sustainable
organic
synthesis.
