Construction of trifluoromethyl-substituted enaminones via rhodium(III)-catalyzed aldehydic C(sp2)–H bond activation of N-sulfonyl-2-aminobenzaldehydes with CF3-imidoyl sulfoxonium ylides DOI

Yubo Duan,

Zhaolin Quan,

Zhengkai Chen

и другие.

Tetrahedron, Год журнала: 2024, Номер unknown, С. 134408 - 134408

Опубликована: Дек. 1, 2024

Язык: Английский

Synthesis of 1,2,4-Diazaphospholes via Base-Promoted Cyclization Reaction of Hydrazonoyl Chlorides and [Bu4N][P(SiCl3)2] DOI
Xin Wang, Hui Luo, Bo Yang

и другие.

Organic & Biomolecular Chemistry, Год журнала: 2024, Номер 22(35), С. 7138 - 7142

Опубликована: Янв. 1, 2024

Aromatic 1,2,4-diazaphospholes featuring distinct hybrid-mode nitrogen atoms (N(λ

Язык: Английский

Процитировано

2
Base-mediated formal [4+1] annulation of ortho-hydroxyphenyl substituted para-quinone methides and CF3-imidoyl sulfoxonium ylides to access trifluoroacetimidoyl-substituted 2,3-dihydrobenzofurans DOI
Chen Li,

Mingshuo Zhou,

Zhengkai Chen

и другие.

Journal of Fluorine Chemistry, Год журнала: 2024, Номер 277, С. 110308 - 110308

Опубликована: Июнь 7, 2024

Язык: Английский

Процитировано

1
Base‐Mediated Cascade Reaction of CF3‐Imidoyl Sulfoxonium Ylides and Diimides for the Synthesis of Functionalized Amidines DOI

Sihao Ling,

Qihua Chen, Zhengkai Chen

и другие.

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер unknown

Опубликована: Окт. 7, 2024

Abstract A base‐mediated cascade reaction of CF 3 ‐imidoyl sulfoxonium ylides (TFISYs) and diimides has been developed for the preparation functionalized amidines. In transformation, a nucleophilic addition subsequent [2,3]‐sigmatropic rearrangement ylide occur to enable an intramolecular migration dimethyl sulfoxide (DMSO). The unexpected result protocol demonstrates chameleonic reactivity TFISYs.

Язык: Английский

Процитировано

1
Design, Synthesis, and Biological Evaluation of N′-Phenylhydrazides as Potential Antifungal Agents DOI Open Access
Panpan Zhu,

Jinshuo Zheng,

Jin Yan

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(20), С. 15120 - 15120

Опубликована: Окт. 12, 2023

Fifty-two kinds of N′-phenylhydrazides were successfully designed and synthesized. Their antifungal activity in vitro against five strains C. albicans (Candida albicans) was evaluated. All prepared compounds showed varying degrees their MIC80 (the concentration tested when inhibition rate at 80%), TAI (total index), TSI susceptibility index) calculated. The inhibitory activities 27/52 fluconazole-resistant fungi 4395 5272 much better than those fluconazole. values 14/52 fungus 5122 less 4 μg/mL, so it the most sensitive (TSIB = 12.0). A11 best SC5314, 4395, (MIC80 1.9, 4.0, 3.7 μg/mL). B14 D5 four (2.71), (2.13), (2.25) are highest. Further exploration mechanisms revealed that treated with compound produced free radicals reactive oxygen species, mycelium morphology damaged. In conclusion, N′-phenylhydrazide scaffold potential development lead compounds. Among them, A11, B14, demonstrated particularly promising held as novel agents.

Язык: Английский

Процитировано

2
Construction of Trifluoromethyl-Substituted Enaminones Via Rhodium(Iii)-Catalyzed Aldehydic C(Sp2)–H Bond Activation of N-Sulfonyl-2-Aminobenzaldehydes with Cf3-Imidoyl Sulfoxonium Ylides DOI

Yubo Duan,

Zhaolin Quan,

Zhengkai Chen

и другие.

Опубликована: Янв. 1, 2024

Язык: Английский

Процитировано

0
Highly Regioselective Dehydrogenative Hydrazination of Tropones DOI

Yan Wang,

Muliang Zhang, Shi‐Kai Tian

и другие.

The Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 15, 2024

Direct C(sp

Язык: Английский

Процитировано

0
Construction of trifluoromethyl-substituted enaminones via rhodium(III)-catalyzed aldehydic C(sp2)–H bond activation of N-sulfonyl-2-aminobenzaldehydes with CF3-imidoyl sulfoxonium ylides DOI

Yubo Duan,

Zhaolin Quan,

Zhengkai Chen

и другие.

Tetrahedron, Год журнала: 2024, Номер unknown, С. 134408 - 134408

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

0