Expedient Synthesis of Antiviral Drug Molnupiravir from D-Ribose and Cytosine DOI Creative Commons

Saptashwa Chakraborty,

Yogesh Sutar, Kameshwar Prasad

и другие.

Опубликована: Янв. 30, 2024

Molnupiravir, an approved antiviral drug for treating SARS-CoV-2-infected patients, presents a critical need concise and sustainable synthesis from readily available raw materials due to its potential high demand. Herein, we report cost-effective scalable synthetic route the API by exploiting mild N-glycosylation conditions utilizing metal-free activation of alkynyl carbonate donor. The overall yield is increased up 48% using minimum purification sequential one-pot reaction.

Язык: Английский

2-(1-Phenylvinyl)benzoic acid as a Highly Active Leaving Group for Metal-Free Glycosylation DOI

Qi Dai,

Penghua Li,

Y. N. Cao

и другие.

Organic Chemistry Frontiers, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

The efficient assembly of O -glycosides and N has been achieved by activating glycosyl ortho -(1-phenylvinyl)benzoate (PVB) with I 2 .

Язык: Английский

Процитировано

0
Expedient synthesis of mucin-type oligosaccharide analogues using alkynyl glycosyl carbonate donors DOI Creative Commons

Boddu Venkateswara Rao,

Jennifer Johns,

M. Carmen Galán

и другие.

Carbohydrate Research, Год журнала: 2025, Номер 553, С. 109497 - 109497

Опубликована: Апрель 17, 2025

Язык: Английский

Процитировано

0
Expedient Synthesis of Antiviral Drug Molnupiravir from D-Ribose and Cytosine DOI Creative Commons

Saptashwa Chakraborty,

Yogesh Sutar, Kameshwar Prasad

и другие.

Опубликована: Янв. 30, 2024

Molnupiravir, an approved antiviral drug for treating SARS-CoV-2-infected patients, presents a critical need concise and sustainable synthesis from readily available raw materials due to its potential high demand. Herein, we report cost-effective scalable synthetic route the API by exploiting mild N-glycosylation conditions utilizing metal-free activation of alkynyl carbonate donor. The overall yield is increased up 48% using minimum purification sequential one-pot reaction.

Язык: Английский

Процитировано

1