Recent advancements in visible-light-induced direct C(3)–H functionalization of quinoxalin-2(1H)-ones
Green Synthesis and Catalysis,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Electrochemical umpolung of C‐H nucleophiles bearing three electron‐withdrawing groups to trigger radical 1,2‐alkylarylations of allylic alcohols
Advanced Synthesis & Catalysis,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 31, 2025
Abstract
The
electrochemical
catalyst‐free
generation
of
carbon
radicals
bearing
three
electron‐withdrawing
groups
from
the
corresponding
C−H
nucleophiles
remains
unexplored.
To
this
end,
we
report
a
direct
electro‐oxidation
strategy
to
access
these
electrophilic
under
conditions.
Enabled
by
strategy,
radical
1,2‐alkylarylations
allylic
alcohols
was
realized,
affording
β
‐quaternary
ketones
with
high
functional
group
compatibility.
This
protocol
is
operationally
simple
and
also
easy
scale
up.
Язык: Английский
TBHP‐Mediated Hydroxyperfluoroalkylation of Alkenes with Perfluoroalkyl Iodides to Construct β‐Perfluoroalkyl Alcohols
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(17), С. 3572 - 3577
Опубликована: Апрель 10, 2024
Abstract
A
three‐component
strategy
for
the
synthesis
of
β‐perfluoroalkyl
allyl
alcohols
from
1,3‐dienes
is
developed.
diverse
range
synthetically
valuable
are
obtained
in
moderate
to
high
yields.
Broad
substrate
scope
and
good
functional
group
tolerance
observed.
This
method
also
applicable
mono‐olefins
1,3‐enynes.
The
control
experiment
results
demonstrate
that
hydroxyl
OH
product
comes
TBHP.
In
addition,
practicality
mild
reaction
conditions
make
these
synthetic
transformations
attractive
organic
synthesis.
Язык: Английский
TMSCN-Promoted Difunctionalization of Alkenes for the Synthesis of Alcohol Derivatives
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
89(17), С. 12062 - 12070
Опубликована: Авг. 15, 2024
A
TMSCN-promoted
difunctionalization
of
styrenes
with
CHCl3
and
TBHP
is
reported
via
the
radical
addition/cross
coupling
process.
wide
range
dichloromethyl-substituted
alcohol
derivatives
were
synthesized
under
transition-metal-free
conditions.
Besides,
this
method
also
applicable
to
unactive
alkenes.
The
key
success
lies
in
role
TMSCN,
which
prevents
reaction
toward
dichloromethylperoxylation
olefins.
This
represents
an
alternative
approach
for
synthesizing
diverse
using
readily
available
substrates,
holding
significant
promise
fields
pharmaceutical
chemistry
natural
product
synthesis.
Язык: Английский
Photocatalytic Hydrodichloromethylation of Unactivated Alkenes with Chloroform
Organic Letters,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 16, 2024
A
visible-light-induced
method
for
the
hydrodichloromethylation
of
unactivated
alkenes
using
chloroform
(CHCl3)
was
developed,
employing
pyridine·BH3
as
halogen
atom
transfer
(XAT)
reagent.
The
strategy
showed
a
broad
functional
group
tolerance,
and
29
examples
alkenes,
including
complex
natural
products
or
drug
derivatives,
have
been
established
with
good
yields.
Mechanistic
studies
indicated
that
CHCl3
serves
both
source
dichloromethyl
radical
hydrogen
(HAT)
reagent,
borane
short-chain
reaction
process
involved
in
this
system.
This
represents
novel
approach
without
an
additional
HAT
Язык: Английский
Amine-Promoted Three-Component Radical Selenofunctionalization for the Construction of β-Hydroxy Selenide Derivatives
The Journal of Organic Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 28, 2024
An
amine-promoted
three-component
radical
selenofunctionalization
reaction
of
alkenes
with
TBHP
and
diselenide
is
disclosed.
The
conditions
are
mild
suitable
for
a
wide
range
substrates
(29
examples),
all
give
the
corresponding
hydroxyselenenylation
products
in
moderate
to
excellent
yields.
In
addition,
preliminary
studies
on
mechanism
reveal
that
current
method
might
proceed
via
pathway.
serves
as
both
initiator
source
hydroxyl
group.
Язык: Английский