Visible Light‐Enabled Decarboxylative Alkylation of Quinoxalin‐2(1H)‐ones using Alkyl Carboxylic Acids via Energy Transfer Process

Advanced Synthesis & Catalysis, Год журнала: 2024, Номер 366(12), С. 2735 - 2741

Опубликована: Апрель 20, 2024

Abstract Here in, we describe the photochemical decarboxylative alkylation of quinoxalin‐2(1 H )‐ones using commercially accessible carboxylic acids with oxygen as sole oxidant through energy transfer process. The coupling diverse array alkyl (1° to 3°) and bioactive is successfully accomplished achieve desired alkylated products.

Язык: Английский

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Visible Light-Induced Sequential Nitrogen Insertion and Benzotriazolation of Quinoxaline-2(1H)-ones

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

Herein, we report a visible light-mediated sequential reaction involving in situ generation of benzotriazole from benzene-1,2-diamine and tert-butyl nitrite via nitrogen insertion concomitant cross-coupling with quinoxaline-2(1H)-ones C-N bond formation one pot. This protocol uses metal-free mild conditions demonstrated 36 examples ≤80% yield wide functional group tolerance.

Язык: Английский

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B(C₆F₅)₃/Chiral Phosphoric Acid Promoted Asymmetric C-3 gem-Difluoroalkylation of Quinoxalin-2-ones with Difluoroenoxysilanes

Organic Letters, Год журнала: 2024, Номер 26(31), С. 6551 - 6555

Опубликована: Июль 30, 2024

The asymmetric Mannich-type reaction of quinoxalin-2-ones with difluoroenoxysilanes has been developed for the synthesis chiral gem-difluoroalkylated quinoxalin-2-ones. worked in presence phosphoric acid CPA 1 and B(C6F5)3 THF at room temperature. exhibited a good substrate scope furnishing products yields (up to 97%) up 96% ee.

Язык: Английский

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¹O₂ mediated synthesis of carbonyl substituted quinoline-2,4(1H,3H)-diones in visible light: 4CzIPN as a reusable photocatalyst

Chemical Communications, Год журнала: 2024, Номер 60(43), С. 5646 - 5649

Опубликована: Янв. 1, 2024

A mild and eco-friendly method for the construction of carbonyl-containing quinoline-2,4(1

Язык: Английский

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Recent advancements in visible-light-induced direct C(3)–H functionalization of quinoxalin-2(1H)-ones

Green Synthesis and Catalysis, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский

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Photooxidative Reaction of β-Oxoamides with Amines for the Synthesis of Pyrrolin-4-ones under External Photocatalyst-Free Conditions

The Journal of Organic Chemistry, Год журнала: 2024, Номер 89(14), С. 9972 - 9978

Опубликована: Июль 2, 2024

The incorporation of oxygen atoms from air under aerobic conditions plays an important role in organic synthesis. Herein, Brønsted acids are found to be a two-in-one strategic catalyst transform enamines β-oxoamides and amines pyrrolin-4-ones without external photocatalyst visible-light conditions. acid can inhibit the C-C bond fragmentation [2 + 2] adduct enamine

Язык: Английский

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¹O₂ and Base Assisted Oxidative Conversion of β-Enaminoesters to α-Acyloxy-β-ketoesters under Visible Light Irradiation

The Journal of Organic Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Сен. 19, 2024

Singlet oxygen (

Язык: Английский

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